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学科主题: 基础医学
题名:
T3098C and T53C Mutations of HBV Genotype C Is Associated with HBV Infection Progress
作者: Jiang, Su-Zhen; Gao, Zhi-Yong; Li, Tong; Li, Ya-Juan; Chen, Xiang-Mei; Wang, Ling; Lu, Feng-Min; Zhuang, Hui
关键词: Hepatitis B virus (HBV) ; Genotype C ; pre S ; Mutation ; Hepatocellular carcinoma (HCC)
刊名: BIOMEDICAL AND ENVIRONMENTAL SCIENCES
发表日期: 2009-12-01
卷: 22, 期:6, 页:511-517
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Environmental Sciences ; Public, Environmental & Occupational Health
研究领域[WOS]: Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
关键词[WOS]: HEPATITIS-B-VIRUS ; PRE-S MUTANTS ; HEPATOCELLULAR-CARCINOMA ; PHYLOGENETIC RELATEDNESS ; PRE-S(2) REGION ; SURFACE-ANTIGEN ; HIGH PREVALENCE ; LIVER-DISEASES ; PROTEINS ; STRESS
英文摘要:

Objective To analyze the association between mutation(s) in preS region of HBV and hepatitis B disease progress in Chinese patients with genotype C chronic HBV infection. Methods Ninety-three patients with chronic genotype C HBV infection, including 24 asymptomatic carriers (ASC), 26 patients with chronic hepatitis B (CHB), 22 patients with liver cirrhosis (LC) and 21 HCC patients were investigated. Levels of HBV DNA, HBeAg, alanine aminotransferase (ALT), asparate transaminase (AST) were measured. HBV preS region was analyzed by PCR direct sequencing. Results The prevalence of preS T3098C and T53C mutations of genotype C HBV was significantly higher in LC and HCC patients than ASC and CHB patients. The rate of T3098C mutation in ASC, CHB, LC, and HCC patients were 0.00% (0/24), 3.85% (1/26), 9.09% (2/22), and 30.77% (8/22), respectively (p=0.0015), while the rate of T53C mutation was 12.50% (3/24), 3.85% (1/26), 40.91% (9/22), and 42.31% (11/26), respectively (p=0.0012). Conclusion The frequency of genotype C HBV preS T3098C and T53C mutations is associated with hepatitis B infection progression.

语种: 英语
所属项目编号: D0805700650805 ; 2005CB523104 ; 2008ZX10002-12 ; 2008ZX10002-004
项目资助者: Beijing Municipal Science & ; Technology Commission ; Basic Research Projec ; National Projects on Major Infectious Diseases ; Ministry of Science and Technology of China
WOS记录号: WOS:000273802700009
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55532
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: Peking Univ, Dept Microbiol, Hlth Sci Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Jiang, Su-Zhen,Gao, Zhi-Yong,Li, Tong,et al. T3098C and T53C Mutations of HBV Genotype C Is Associated with HBV Infection Progress[J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2009,22(6):511-517.
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