IR@PKUHSC  > 北京大学基础医学院  > 病原生物学系
学科主题基础医学
T3098C and T53C Mutations of HBV Genotype C Is Associated with HBV Infection Progress
Jiang, Su-Zhen; Gao, Zhi-Yong; Li, Tong; Li, Ya-Juan; Chen, Xiang-Mei; Wang, Ling; Lu, Feng-Min; Zhuang, Hui
关键词Hepatitis B virus (HBV) Genotype C pre S Mutation Hepatocellular carcinoma (HCC)
刊名BIOMEDICAL AND ENVIRONMENTAL SCIENCES
2009-12-01
22期:6页:511-517
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Environmental Sciences ; Public, Environmental & Occupational Health
资助者Beijing Municipal Science & ; Technology Commission ; Basic Research Projec ; National Projects on Major Infectious Diseases ; Ministry of Science and Technology of China ; Beijing Municipal Science & ; Technology Commission ; Basic Research Projec ; National Projects on Major Infectious Diseases ; Ministry of Science and Technology of China
研究领域[WOS]Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
关键词[WOS]HEPATITIS-B-VIRUS ; PRE-S MUTANTS ; HEPATOCELLULAR-CARCINOMA ; PHYLOGENETIC RELATEDNESS ; PRE-S(2) REGION ; SURFACE-ANTIGEN ; HIGH PREVALENCE ; LIVER-DISEASES ; PROTEINS ; STRESS
英文摘要

Objective To analyze the association between mutation(s) in preS region of HBV and hepatitis B disease progress in Chinese patients with genotype C chronic HBV infection. Methods Ninety-three patients with chronic genotype C HBV infection, including 24 asymptomatic carriers (ASC), 26 patients with chronic hepatitis B (CHB), 22 patients with liver cirrhosis (LC) and 21 HCC patients were investigated. Levels of HBV DNA, HBeAg, alanine aminotransferase (ALT), asparate transaminase (AST) were measured. HBV preS region was analyzed by PCR direct sequencing. Results The prevalence of preS T3098C and T53C mutations of genotype C HBV was significantly higher in LC and HCC patients than ASC and CHB patients. The rate of T3098C mutation in ASC, CHB, LC, and HCC patients were 0.00% (0/24), 3.85% (1/26), 9.09% (2/22), and 30.77% (8/22), respectively (p=0.0015), while the rate of T53C mutation was 12.50% (3/24), 3.85% (1/26), 40.91% (9/22), and 42.31% (11/26), respectively (p=0.0012). Conclusion The frequency of genotype C HBV preS T3098C and T53C mutations is associated with hepatitis B infection progression.

语种英语
所属项目编号D0805700650805 ; 2005CB523104 ; 2008ZX10002-12 ; 2008ZX10002-004
资助者Beijing Municipal Science & ; Technology Commission ; Basic Research Projec ; National Projects on Major Infectious Diseases ; Ministry of Science and Technology of China ; Beijing Municipal Science & ; Technology Commission ; Basic Research Projec ; National Projects on Major Infectious Diseases ; Ministry of Science and Technology of China
WOS记录号WOS:000273802700009
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55532
专题北京大学基础医学院_病原生物学系
作者单位Peking Univ, Dept Microbiol, Hlth Sci Ctr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Jiang, Su-Zhen,Gao, Zhi-Yong,Li, Tong,et al. T3098C and T53C Mutations of HBV Genotype C Is Associated with HBV Infection Progress[J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2009,22(6):511-517.
APA Jiang, Su-Zhen.,Gao, Zhi-Yong.,Li, Tong.,Li, Ya-Juan.,Chen, Xiang-Mei.,...&Zhuang, Hui.(2009).T3098C and T53C Mutations of HBV Genotype C Is Associated with HBV Infection Progress.BIOMEDICAL AND ENVIRONMENTAL SCIENCES,22(6),511-517.
MLA Jiang, Su-Zhen,et al."T3098C and T53C Mutations of HBV Genotype C Is Associated with HBV Infection Progress".BIOMEDICAL AND ENVIRONMENTAL SCIENCES 22.6(2009):511-517.
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