IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科
学科主题临床医学
Tubulointerstitial lesions of patients with lupus nephritis classified by the 2003 International Society of Nephrology and Renal Pathology Society system
Yu, Feng1,2,3; Wu, Li-hua4; Tan, Ying1,2,3; Li, Li-hua5; Wang, Cai-li6; Wang, Wen-ke7; Qu, Zhen1,2,3; Chen, Meng-hua4; Gao, Jun-jie5; Li, Zeng-yan6; Zheng, Xin1,2,3; Ao, Jie1,2,3; Zhu, Sai-nan8; Wang, Su-xia1,2,3; Zhao, Ming-hui1,2,3; Zou, Wan-zhong1,2,3; Liu, Gang1,2,3
关键词Classification Lupus Nephritis Tubulointerstitial Lesions
刊名KIDNEY INTERNATIONAL
2010-05-01
DOI10.1038/ki.2010.13
77期:9页:820-829
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]CLASS-IV-G ; KAPPA-B ACTIVATION ; INTRAVENOUS CYCLOPHOSPHAMIDE ; MYCOPHENOLATE-MOFETIL ; INDUCTION TREATMENT ; INTERSTITIAL-CELLS ; DISEASE-ACTIVITY ; ERYTHEMATOSUS ; GLOMERULONEPHRITIS ; PROGNOSIS
英文摘要

The 2003 International Society of Nephrology/Renal Pathology Society (ISN/RPS) system for classifying patients with lupus nephritis was based on glomerular lesions exclusively, despite the fact that lupus nephritis affects all compartments of the kidney. Hence, we analyzed the tubulointerstitial lesions in patients with lupus nephritis within the different classes and subclasses of the 2003 ISN/RPS system. Among 313 patients from five centers in northern China with lupus nephritis, interstitial inflammatory cell infiltration, tubular atrophy, and interstitial fibrosis were severe in 170 patients with class IV, moderate in 55 with class III, and mild in 19 with class II and in 69 with class V disease, each with significance. The severity of tubulointerstitial lesions in classes IV-segmental and III was similar, whereas the score of interstitial inflammatory cell infiltration in patients with subclass IV-global was significantly higher than that in those with subclass IV-segmental. Interstitial fibrosis and tubular atrophy were each significantly more prominent in patients with both active and chronic lesions than in those with active lesions alone. The correlation coefficient ranged from 0.222 to 0.811 comparing glomerular and tubulointerstitial indices. In multivariate Cox hazard analysis of tubulointerstitial lesions, indices of interstitial infiltration, tubular atrophy, and interstitial fibrosis were confirmed as significant independent risk factors for renal outcome. Thus, we found that the 2003 ISN/RPS classification system of lupus nephritis, based on glomerular lesions, could also reflect related tubulointerstitial lesions. Hence, we suggest that the extent of tubulointerstitial lesions may be helpful in predicting renal outcome in patients with lupus nephritis. Kidney International (2010) 77, 820-829; doi: 10.1038/ki.2010.13; published online 24 February 2010

语种英语
WOS记录号WOS:000276662000013
项目编号PCSIRT-IRT0803
资助机构Program for Changjiang Scholars and Innovative Research Team in University
引用统计
被引频次:83[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55533
专题北京大学第一临床医学院_肾脏内科
北京大学基础医学院
北京大学第一临床医学院_电镜室
北京大学第一临床医学院_医学统计室
作者单位1.Cangzhou Cent Hosp, Dept Nephrol, Cangzhou, Hebei, Peoples R China
2.Chifeng Second Hosp, Dept Nephrol, Neimenggu, Peoples R China
3.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
4.Peking Univ, Inst Nephrol, Beijing 100871, Peoples R China
5.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100871, Peoples R China
6.Ningxia Med Univ, Affiliated Hosp, Dept Nephrol, Nangxia, Peoples R China
7.Affiliated Hosp 1, Baotou Med Coll, Dept Nephrol, Neimenggu, Peoples R China
8.Peking Univ, Hosp 1, Dept Biostat, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Yu, Feng,Wu, Li-hua,Tan, Ying,et al. Tubulointerstitial lesions of patients with lupus nephritis classified by the 2003 International Society of Nephrology and Renal Pathology Society system[J]. KIDNEY INTERNATIONAL,2010,77(9):820-829.
APA Yu, Feng.,Wu, Li-hua.,Tan, Ying.,Li, Li-hua.,Wang, Cai-li.,...&Liu, Gang.(2010).Tubulointerstitial lesions of patients with lupus nephritis classified by the 2003 International Society of Nephrology and Renal Pathology Society system.KIDNEY INTERNATIONAL,77(9),820-829.
MLA Yu, Feng,et al."Tubulointerstitial lesions of patients with lupus nephritis classified by the 2003 International Society of Nephrology and Renal Pathology Society system".KIDNEY INTERNATIONAL 77.9(2010):820-829.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Tubulointerstitial l(296KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yu, Feng]的文章
[Wu, Li-hua]的文章
[Tan, Ying]的文章
百度学术
百度学术中相似的文章
[Yu, Feng]的文章
[Wu, Li-hua]的文章
[Tan, Ying]的文章
必应学术
必应学术中相似的文章
[Yu, Feng]的文章
[Wu, Li-hua]的文章
[Tan, Ying]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Tubulointerstitial lesions of patients with lupus nephritis classified by the 2003 International Society of Nephrology and Renal Pathology Society system.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。