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学科主题: 临床医学
题名:
Tubulointerstitial lesions of patients with lupus nephritis classified by the 2003 International Society of Nephrology and Renal Pathology Society system
作者: Yu, Feng1,2,3; Wu, Li-hua4; Tan, Ying1,2,3; Li, Li-hua5; Wang, Cai-li6; Wang, Wen-ke7; Qu, Zhen1,2,3; Chen, Meng-hua4; Gao, Jun-jie5; Li, Zeng-yan6; Zheng, Xin1,2,3; Ao, Jie1,2,3; Zhu, Sai-nan8; Wang, Su-xia1,2,3; Zhao, Ming-hui1,2,3; Zou, Wan-zhong1,2,3; Liu, Gang1,2,3
关键词: classification ; lupus nephritis ; tubulointerstitial lesions
刊名: KIDNEY INTERNATIONAL
发表日期: 2010-05-01
DOI: 10.1038/ki.2010.13
卷: 77, 期:9, 页:820-829
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: CLASS-IV-G ; KAPPA-B ACTIVATION ; INTRAVENOUS CYCLOPHOSPHAMIDE ; MYCOPHENOLATE-MOFETIL ; INDUCTION TREATMENT ; INTERSTITIAL-CELLS ; DISEASE-ACTIVITY ; ERYTHEMATOSUS ; GLOMERULONEPHRITIS ; PROGNOSIS
英文摘要:

The 2003 International Society of Nephrology/Renal Pathology Society (ISN/RPS) system for classifying patients with lupus nephritis was based on glomerular lesions exclusively, despite the fact that lupus nephritis affects all compartments of the kidney. Hence, we analyzed the tubulointerstitial lesions in patients with lupus nephritis within the different classes and subclasses of the 2003 ISN/RPS system. Among 313 patients from five centers in northern China with lupus nephritis, interstitial inflammatory cell infiltration, tubular atrophy, and interstitial fibrosis were severe in 170 patients with class IV, moderate in 55 with class III, and mild in 19 with class II and in 69 with class V disease, each with significance. The severity of tubulointerstitial lesions in classes IV-segmental and III was similar, whereas the score of interstitial inflammatory cell infiltration in patients with subclass IV-global was significantly higher than that in those with subclass IV-segmental. Interstitial fibrosis and tubular atrophy were each significantly more prominent in patients with both active and chronic lesions than in those with active lesions alone. The correlation coefficient ranged from 0.222 to 0.811 comparing glomerular and tubulointerstitial indices. In multivariate Cox hazard analysis of tubulointerstitial lesions, indices of interstitial infiltration, tubular atrophy, and interstitial fibrosis were confirmed as significant independent risk factors for renal outcome. Thus, we found that the 2003 ISN/RPS classification system of lupus nephritis, based on glomerular lesions, could also reflect related tubulointerstitial lesions. Hence, we suggest that the extent of tubulointerstitial lesions may be helpful in predicting renal outcome in patients with lupus nephritis. Kidney International (2010) 77, 820-829; doi: 10.1038/ki.2010.13; published online 24 February 2010

语种: 英语
所属项目编号: PCSIRT-IRT0803
项目资助者: Program for Changjiang Scholars and Innovative Research Team in University
WOS记录号: WOS:000276662000013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55533
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Cangzhou Cent Hosp, Dept Nephrol, Cangzhou, Hebei, Peoples R China
2.Chifeng Second Hosp, Dept Nephrol, Neimenggu, Peoples R China
3.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
4.Peking Univ, Inst Nephrol, Beijing 100871, Peoples R China
5.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100871, Peoples R China
6.Ningxia Med Univ, Affiliated Hosp, Dept Nephrol, Nangxia, Peoples R China
7.Affiliated Hosp 1, Baotou Med Coll, Dept Nephrol, Neimenggu, Peoples R China
8.Peking Univ, Hosp 1, Dept Biostat, Beijing 100871, Peoples R China

Recommended Citation:
Yu, Feng,Wu, Li-hua,Tan, Ying,et al. Tubulointerstitial lesions of patients with lupus nephritis classified by the 2003 International Society of Nephrology and Renal Pathology Society system[J]. KIDNEY INTERNATIONAL,2010,77(9):820-829.
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