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Chinese soft-shelled turtle egg powder lowers serum cholesterol, increases faecal neutral steroids and bile acid excretion, and up-regulates liver cytochrome P450 mRNA level in rats
Yu, HL; Li, Y; Wang, JB; Zheng, LP; Yan, WX
关键词Lipid-lowering Faecal Bile Acid Steroids Low Cholesterol
刊名BRITISH JOURNAL OF NUTRITION
2005-09-01
DOI10.1079/BJN20051485
94期:3页:315-320
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nutrition & Dietetics
研究领域[WOS]Nutrition & Dietetics
关键词[WOS]PLASMA-CHOLESTEROL ; PROTEIN ; HAMSTERS ; DIET ; ABSORPTION ; SOY ; MITOCHONDRIA ; LIPIDS ; ALPHA
英文摘要

The aim of the present study was to investigate the effect of Chinese soft-shelled turtle whole egg powder (TE) on cholesterol metabolism in Sprague-Dawley rats to determine whether it has a cholesterol-lowering effect. Forty male Sprague-Dawley rats were fed a high-fat diet supplemented with TE (0, 0.75, 1.50 or 3.00 g/kg body weight) administrated by gavage for 24 weeks. Serum total cholesterol (TC), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C) and faecal total bile acids levels were determined by enzymatic methods. Faecal steroid concentrations were measured by GC. Means and standard deviations were calculated where appropriate for values, and the data were tested by one-way ANOVA. After 24 weeks of feeding a high-fat diet with TE supplementation, serum TC and LDL-C levels, liver cholesterol and liver lipid levels were reduced in rats. TE supplementation did not affect the faecal output, but significantly increased steroid concentrations in faeces, indicating increased steroids excretion. The faecal bile acid excretion was also increased as evidence by elevated mRNA level of liver cytochrome P450, family 7, subfamily A, polypeptide 1. Our results demonstrated that the TE does have a cholesterol-lowering effect by increasing the excretion of total bile acids and neutral steroids.

语种英语
WOS记录号WOS:000231978600003
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被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55534
专题北京大学公共卫生学院
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100083, Peoples R China
2.Chinese Ctr Dis Control & Prevent, Inst Nutr & Food Safety, Beijing, Peoples R China
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GB/T 7714
Yu, HL,Li, Y,Wang, JB,et al. Chinese soft-shelled turtle egg powder lowers serum cholesterol, increases faecal neutral steroids and bile acid excretion, and up-regulates liver cytochrome P450 mRNA level in rats[J]. BRITISH JOURNAL OF NUTRITION,2005,94(3):315-320.
APA Yu, HL,Li, Y,Wang, JB,Zheng, LP,&Yan, WX.(2005).Chinese soft-shelled turtle egg powder lowers serum cholesterol, increases faecal neutral steroids and bile acid excretion, and up-regulates liver cytochrome P450 mRNA level in rats.BRITISH JOURNAL OF NUTRITION,94(3),315-320.
MLA Yu, HL,et al."Chinese soft-shelled turtle egg powder lowers serum cholesterol, increases faecal neutral steroids and bile acid excretion, and up-regulates liver cytochrome P450 mRNA level in rats".BRITISH JOURNAL OF NUTRITION 94.3(2005):315-320.
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