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Traditional Medicine in the Treatment of Drug Addiction
Lu, Lin1; Liu, Yanli2; Zhu, Weili1; Shi, Jie1; Liu, Yu1; Ling, Walter3; Kosten, Thomas R.4
关键词Acupuncture Drug Abuse Traditional Medicine Treatment
刊名AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE
2009
DOI10.1080/00952990802455469
35期:1页:1-11
收录类别SSCI
文章类型Review
WOS标题词Social Sciences ; Science & Technology
类目[WOS]Psychology, Clinical ; Substance Abuse
研究领域[WOS]Psychology ; Substance Abuse
关键词[WOS]CONDITIONED PLACE PREFERENCE ; MITOCHONDRIAL ALDEHYDE DEHYDROGENASE ; INDUCED LOCOMOTOR STIMULATION ; ALCOHOL-WITHDRAWAL SYMPTOMS ; RANDOMIZED-CONTROLLED-TRIAL ; STRIATAL DOPAMINE RELEASE ; SYRIAN GOLDEN-HAMSTERS ; RECEIVING FREE-ACCESS ; GINSENG TOTAL SAPONIN ; C-FOS EXPRESSION
英文摘要

Aims: To evaluate clinical trials and neurochemical mechanisms of the action of traditional herbal remedies and acupuncture for treating drug addiction. Methods: We used computerized literature searches in English and Chinese and examined texts written before these computerized databases existed. We used search terms of treatment and neurobiology of herbal medicines, and acupuncture for drug abuse and dependence. Results: Acupuncture showed evidence for clinical efficacy and relevant neurobiological mechanisms in opiate withdrawal, but it showed poor efficacy for alcohol and nicotine withdrawal or relapse prevention, and no large studies supported its efficacy for cocaine in well-designed clinical trials. Clinical trials were rare for herbal remedies. Radix Puerariae showed the most promising efficacy for alcoholism by acting through daidzin, which inhibits mitocochondrial aldehyde dehydrogenase 2 and leads to disulfiram-like alcohol reactions. Peyote also has some evidence for alcoholism treatment among Native Americans. Ginseng and Kava lack efficacy data in addictions, and Kava can be hepatotoxic. Thunbergia laurifolia can protect against alcoholic liver toxicity. Withania somnifera and Salvia miltiorrhiza have no efficacy data, but can reduce morphine tolerance and alcohol intake, respectively, in animal models. Conclusions: Traditional herbal treatments can compliment pharmacotherapies for drug withdrawal and possibly relapse prevention with less expense and perhaps fewer side effects with notable exceptions. Both acupuncture and herbal treatments need testing as adjuncts to reduce doses and durations of standard pharmacotherapies.

语种英语
WOS记录号WOS:000262508900001
Citation statistics
Cited Times:32[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55536
Collection中国药物依赖性研究所
作者单位1.Soochow Univ, Coll Pharm, Suzhou, Peoples R China
2.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
3.Univ Calif Los Angeles, David Geffen Sch Med, Integrated Substance Abuse Programs, Los Angeles, CA 90095 USA
4.Baylor Coll Med, Div Alcohol & Addict Disorders, Houston, TX 77030 USA
Recommended Citation
GB/T 7714
Lu, Lin,Liu, Yanli,Zhu, Weili,et al. Traditional Medicine in the Treatment of Drug Addiction[J]. AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE,2009,35(1):1-11.
APA Lu, Lin.,Liu, Yanli.,Zhu, Weili.,Shi, Jie.,Liu, Yu.,...&Kosten, Thomas R..(2009).Traditional Medicine in the Treatment of Drug Addiction.AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE,35(1),1-11.
MLA Lu, Lin,et al."Traditional Medicine in the Treatment of Drug Addiction".AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE 35.1(2009):1-11.
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