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Adenovirus-mediated PDCD5 gene transfer sensitizes K562 cells to apoptosis induced by idarubicin in vitro and in vivo
Ruan, Guo-Rui; Zhao, Hong-Shan3; Chang, Yan; Li, Jin-Lan; Qin, Ya-Zhen; Liu, Yan-Rong; Chen, Shan-Shan1; Huang, Xiao-Jun1
关键词Pdcd5 Gene Therapy Adenoviral Vector Idarubicin Leukemia Nude Mice
刊名APOPTOSIS
2008-05-01
DOI10.1007/s10495-008-0206-9
13期:5页:641-648
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]TOPOISOMERASE-II ; EXPRESSION PROFILES ; BREAST-CANCER ; TUMOR-CELLS ; THERAPY ; LEUKEMIA ; MODEL ; INHIBITORS ; GROWTH ; TFAR19
英文摘要

PDCD5 (programmed cell death 5) accelerates apoptosis of certain tumor cells and is expressed at low levels in marrow-nucleated cells of AML and CML patients. In the present study, we evaluated the effects of PDCD5 overexpression on drug sensitivity of leukemia cells. K562 cells were treated with idarubicin (IDR) alone or in combination with adenoviral vectors expressing PDCD5 (Ad-PDCD5). As shown by annexin-V-FITC/PI dual labeling, apoptosis rates were markedly increased after combined treatment with Ad-PDCD5 compared to IDR treatment alone. We observed that PDCD5 overexpression significantly improves the antitumor effects of low dose IDR treatment in vivo. Tumor sizes were significantly decreased in combined Ad-PDCD5 and low dose IDR treatment groups compared with single IDR treatment groups. Similar results were obtained with combined systemic treatment of Ad-PDCD5 and low dose IDR, and combined treatment with Ad-PDCD5 local injection and low dose IDR i.p. injection. These results indicate that Ad-PDCD5 may be a promising agent for enhancing chemosensitivity.

语种英语
WOS记录号WOS:000255030400004
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被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55537
专题北京大学第二临床医学院
北京大学基础医学院
北京大学第二临床医学院_血液科
北京大学临床肿瘤学院_移植与免疫治疗病区
作者单位1.Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China
2.Inst Hematol, Beijing 100044, Peoples R China
3.Peking Univ, Ctr Human Dis Genom, Beijing 100083, Peoples R China
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Ruan, Guo-Rui,Zhao, Hong-Shan,Chang, Yan,et al. Adenovirus-mediated PDCD5 gene transfer sensitizes K562 cells to apoptosis induced by idarubicin in vitro and in vivo[J]. APOPTOSIS,2008,13(5):641-648.
APA Ruan, Guo-Rui.,Zhao, Hong-Shan.,Chang, Yan.,Li, Jin-Lan.,Qin, Ya-Zhen.,...&Huang, Xiao-Jun.(2008).Adenovirus-mediated PDCD5 gene transfer sensitizes K562 cells to apoptosis induced by idarubicin in vitro and in vivo.APOPTOSIS,13(5),641-648.
MLA Ruan, Guo-Rui,et al."Adenovirus-mediated PDCD5 gene transfer sensitizes K562 cells to apoptosis induced by idarubicin in vitro and in vivo".APOPTOSIS 13.5(2008):641-648.
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