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Non-invasive assessment of liver fibrosis in patients with alcoholic liver disease using acoustic radiation force impulse elastography
Zhang, Dakun1; Li, Peng2; Chen, Min1; Liu, Liping3; Liu, Yang1; Zhao, Yuanyuan4; Wang, Ruifang1
关键词Acoustic Radiation Force Impulse Elastography Alcoholic Liver Disease Cirrhosis Liver Fibrosis
刊名ABDOMINAL IMAGING
2015-04-01
DOI10.1007/s00261-014-0154-5
40期:4页:723-729
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Gastroenterology & Hepatology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]CHRONIC HEPATITIS-C ; CHRONIC VIRAL-HEPATITIS ; TRANSIENT ELASTOGRAPHY ; ARFI ELASTOGRAPHY ; STIFFNESS ; BIOPSY ; COMPLICATIONS ; MULTICENTER ; INFECTION
英文摘要

To investigate the diagnostic performance of the acoustic radiation force impulse (ARFI) elastography for the assessment of the liver fibrosis in alcoholic liver disease (ALD).

We included 112 patients with ALD in whom liver biopsy, ARFI elastography, and aspartate-to-platelet ratio index (APRI) measurements were performed.

ARFI elastography correlated significantly with histological fibrosis (r = 0.685, P < 0.001) in patients with ALD. The diagnostic accuracies expressed as areas under receiver operating characteristic (AUROC) curves for ARFI elastography and APRI were 0.846 and 0.763 for the diagnosis of significant fibrosis (S a parts per thousand yen 2), 0.875 and 0.688 for the diagnosis of severe fibrosis (S a parts per thousand yen 3), and 0.893 and 0.648 for the diagnosis of liver cirrhosis, respectively. The AUROC values of ARFI elastography were significantly better than those of APRI for predicting severe fibrosis (P = 0.02) and cirrhosis (P = 0.04). The optimum cutoff values for ARFI elastography were 1.33 m/s for S a parts per thousand yen 2, 1.40 m/s for S a parts per thousand yen 3, and 1.65 m/s for S = 4 in patients with elevated alanine aminotransferase (ALT) levels; these decreased to 1.24 m/s for S a parts per thousand yen 2, 1.27 m/s for S a parts per thousand yen 3, and 1.41 m/s for S = 4 in patients with normal ALT.

ARFI elastography is an acceptable method for predicting the severity of fibrosis in patients with ALD. ARFI elastography is influenced by elevated aminotransferase levels in ALD.

语种英语
WOS记录号WOS:000351697000005
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55539
专题北京大学口腔医学院
北京大学精神卫生研究所_精神科
作者单位1.302 Hosp PLA, Dept Ultrasound, Beijing 100039, Peoples R China
2.Peking Univ, Clin Dept 2, Sch Stomatol, Beijing 100101, Peoples R China
3.Shanxi Med Univ, Dept Ultrasound, Hosp 1, Taiyuan 030001, Peoples R China
4.Shandong Univ, Qi Lu Hosp Qing Dao, Dept Ultrasound, Qingdao 266000, Peoples R China
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GB/T 7714
Zhang, Dakun,Li, Peng,Chen, Min,et al. Non-invasive assessment of liver fibrosis in patients with alcoholic liver disease using acoustic radiation force impulse elastography[J]. ABDOMINAL IMAGING,2015,40(4):723-729.
APA Zhang, Dakun.,Li, Peng.,Chen, Min.,Liu, Liping.,Liu, Yang.,...&Wang, Ruifang.(2015).Non-invasive assessment of liver fibrosis in patients with alcoholic liver disease using acoustic radiation force impulse elastography.ABDOMINAL IMAGING,40(4),723-729.
MLA Zhang, Dakun,et al."Non-invasive assessment of liver fibrosis in patients with alcoholic liver disease using acoustic radiation force impulse elastography".ABDOMINAL IMAGING 40.4(2015):723-729.
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