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学科主题: 口腔医学
题名:
Non-invasive assessment of liver fibrosis in patients with alcoholic liver disease using acoustic radiation force impulse elastography
作者: Zhang, Dakun1; Li, Peng2; Chen, Min1; Liu, Liping3; Liu, Yang1; Zhao, Yuanyuan4; Wang, Ruifang1
关键词: Acoustic radiation force impulse elastography ; Alcoholic liver disease ; Cirrhosis ; Liver fibrosis
刊名: ABDOMINAL IMAGING
发表日期: 2015-04-01
DOI: 10.1007/s00261-014-0154-5
卷: 40, 期:4, 页:723-729
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Gastroenterology & Hepatology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: CHRONIC HEPATITIS-C ; CHRONIC VIRAL-HEPATITIS ; TRANSIENT ELASTOGRAPHY ; ARFI ELASTOGRAPHY ; STIFFNESS ; BIOPSY ; COMPLICATIONS ; MULTICENTER ; INFECTION
英文摘要:

To investigate the diagnostic performance of the acoustic radiation force impulse (ARFI) elastography for the assessment of the liver fibrosis in alcoholic liver disease (ALD).

We included 112 patients with ALD in whom liver biopsy, ARFI elastography, and aspartate-to-platelet ratio index (APRI) measurements were performed.

ARFI elastography correlated significantly with histological fibrosis (r = 0.685, P < 0.001) in patients with ALD. The diagnostic accuracies expressed as areas under receiver operating characteristic (AUROC) curves for ARFI elastography and APRI were 0.846 and 0.763 for the diagnosis of significant fibrosis (S a parts per thousand yen 2), 0.875 and 0.688 for the diagnosis of severe fibrosis (S a parts per thousand yen 3), and 0.893 and 0.648 for the diagnosis of liver cirrhosis, respectively. The AUROC values of ARFI elastography were significantly better than those of APRI for predicting severe fibrosis (P = 0.02) and cirrhosis (P = 0.04). The optimum cutoff values for ARFI elastography were 1.33 m/s for S a parts per thousand yen 2, 1.40 m/s for S a parts per thousand yen 3, and 1.65 m/s for S = 4 in patients with elevated alanine aminotransferase (ALT) levels; these decreased to 1.24 m/s for S a parts per thousand yen 2, 1.27 m/s for S a parts per thousand yen 3, and 1.41 m/s for S = 4 in patients with normal ALT.

ARFI elastography is an acceptable method for predicting the severity of fibrosis in patients with ALD. ARFI elastography is influenced by elevated aminotransferase levels in ALD.

语种: 英语
WOS记录号: WOS:000351697000005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55539
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.302 Hosp PLA, Dept Ultrasound, Beijing 100039, Peoples R China
2.Peking Univ, Clin Dept 2, Sch Stomatol, Beijing 100101, Peoples R China
3.Shanxi Med Univ, Dept Ultrasound, Hosp 1, Taiyuan 030001, Peoples R China
4.Shandong Univ, Qi Lu Hosp Qing Dao, Dept Ultrasound, Qingdao 266000, Peoples R China

Recommended Citation:
Zhang, Dakun,Li, Peng,Chen, Min,et al. Non-invasive assessment of liver fibrosis in patients with alcoholic liver disease using acoustic radiation force impulse elastography[J]. ABDOMINAL IMAGING,2015,40(4):723-729.
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