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Natural history of immunoglobulin A nephropathy and predictive factors of prognosis: A long-term follow up of 204 cases in China
Lv, Jicheng1,2; Zhang, Hong1,2; Zhou, Yang1,2; Li, Guangtao1,2; Zou, Wanzhong1,2; Wang, Haiyan1,2
关键词Chinese Iga Nephropathy Renal Failure
刊名NEPHROLOGY
2008-04-01
DOI10.1111/j.1440-1797.2007.00898.x
13期:3页:242-246
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]IGA NEPHROPATHY ; DISEASE ; RISK
英文摘要

Aim: Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. However, its natural history and risk factors are not well understood. Our aim was to identify the clinical and pathological factors that could predict disease prognosis in Chinese patients.

Methods: We studied 204 biopsy-diagnosed IgAN patients, who were followed for an average of 6.1 years (range, 4-15 years). Chronic kidney disease (CKD) classified according to the Kidney Disease Outcomes Quality Initiative practice guidelines. Renal pathological lesions were graded single-blindedly according to the Haas classification. The glomerular filtration rate was estimated by the Modification of Diet in Renal Disease equation for Chinese subjects.

Results: Patients with CKD were classified as stage 1 (38.10%), stage 2 (35.40%), stage 3 (13.30%), stage 4 (9.90%) and stage 5 (3.30%). During the follow up, 31 patients had progressed to end-stage renal disease. The renal survival rate following biopsy was 85.1% at the fifth year, and 77.1% at the 10th year. Univariate analysis indicated that patients who were male, had hypertension, proteinuria of more than 1 g/day, renal impairment (estimated glomerular filtration rate, <60 mL/min.1.73 m(2)), and a high histological grading were associated with poor prognosis. Multivariate analysis indicated that the relative risk of renal failure for patients was 3.9 (P = 0.000) for patients with renal impairment, 2.8 (P = 0.019) for patients with hypertension, and 2.0 (P = 0.003) for patients with high histological grading.

Conclusion: We described the natural history of IgAN through follow ups of a relatively large cohort of patients. Most patients were biopsied at an early stage; however, the long-term prognosis was still poor. Patients with renal impairment, hypertension and advanced histological involvement had the highest risk for disease progression.

语种英语
WOS记录号WOS:000254578500010
引用统计
被引频次:58[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55540
专题北京大学第一临床医学院_肾脏内科
北京大学基础医学院
北京大学第一临床医学院_病理科
北京大学口腔医学院_第一门诊部
作者单位1.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
2.Peking Univ, Inst Nephrol, Peking Univ Hosp 1, Div Renal,Dept Med, Beijing 100034, Peoples R China
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GB/T 7714
Lv, Jicheng,Zhang, Hong,Zhou, Yang,et al. Natural history of immunoglobulin A nephropathy and predictive factors of prognosis: A long-term follow up of 204 cases in China[J]. NEPHROLOGY,2008,13(3):242-246.
APA Lv, Jicheng,Zhang, Hong,Zhou, Yang,Li, Guangtao,Zou, Wanzhong,&Wang, Haiyan.(2008).Natural history of immunoglobulin A nephropathy and predictive factors of prognosis: A long-term follow up of 204 cases in China.NEPHROLOGY,13(3),242-246.
MLA Lv, Jicheng,et al."Natural history of immunoglobulin A nephropathy and predictive factors of prognosis: A long-term follow up of 204 cases in China".NEPHROLOGY 13.3(2008):242-246.
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