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学科主题: 基础医学
题名:
Extra copies of ALK gene locus is a recurrent genetic aberration and favorable prognostic factor in both ALK-positive and ALK-negative anaplastic large cell lymphomas
作者: Yu, Ran1,2; Chen, Gang3; Zhou, Chunju4; Gao, Zifen5; Shi, Yunfei5; Shi, Yan6; Zhou, Xiaoge7; Xie, Jianlan7; Liu, Hongxiang8,9; Gong, Liping1
关键词: Anaplastic large cell lymphoma (ALCL) ; Anaplastic lymphoma kinase (ALK) ; Molecular genetics ; Fluorescence in situ hybridization (FISH)
刊名: LEUKEMIA RESEARCH
发表日期: 2012-09-01
DOI: 10.1016/j.leukres.2012.06.005
卷: 36, 期:9, 页:1141-1146
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Hematology
研究领域[WOS]: Oncology ; Hematology
关键词[WOS]: CHROMOSOMAL TRANSLOCATION ; KINASE ; NEUROBLASTOMA ; MUTATIONS
英文摘要:

Systemic anaplastic large cell lymphoma (ALCL) is subtyped into ALK-positive ALCL and ALK-negative ALCL based on the presence or absence of ALK protein expression. ALK-positive ALCL is characterized by t(2;5)(p23;q35)/NPM-ALK or variant ALK-involved translocations, while little is known about the genetic changes in ALK-negative ALCL. We investigated the structural and numerical aberrations of the ALK gene using interphase fluorescence in situ hybridization (FISH) in 81 cases with ALCL and analyzed their association with clinical outcome of the patients. ALK gene rearrangement was found in 47 of 50 (94%) ALK- positive ALCLs but in none of 31 ALK-negative ALCLs. Extra copies of the ALK gene locus, representing mainly extra copies of chromosome 2, were seen in 19 ALK-positive (38%) and 15 ALK-negative (48%) cases (P = 0.357). In 55 cases with follow-up information, the mean survival time of the 38 ALK positive cases (58 months) was significantly longer than that of 17 ALK-negative cases (22.5 months) (P = 0.038). Interestingly, the cases with extra copies of ALK had a significantly longer mean survival time than those without (64.4 months vs 35.3 months) (P = 0.023) and this difference was observed in both ALK-positive (72.3 vs 45.9 months) and ALK-negative (34.7 vs 9.9 months) cases. Multivariate analysis showed that both ALK protein expression and extra copies of ALK gene were independent predictors for better survival (P = 0.008). Our results suggest that the extra copies of ALK gene locus are a frequent genetic aberration in both ALK-positive and ALK-negative ALCL and is a favorable prognostic marker for the patients. (c) 2012 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 7122025 ; 2007-1030
项目资助者: Beijng Natural Science Foundation of China ; Beijing Medicine Research and Development Fund, China
WOS记录号: WOS:000306523600020
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55545
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Weifang Nursing Vocat Coll, Dept Basic Sci, Weifang, Peoples R China
2.Fujian Prov Tumor Hosp, Dept Pathol, Fuzhou, Peoples R China
3.Capital Med Univ, Dept Pathol, Basic Med Coll, Beijing 100069, Peoples R China
4.Capital Med Univ, Beijing Childrens Hosp, Dept Pathol, Beijing, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100871, Peoples R China
6.Harbin Med Univ, Affiliated Hosp 2, Dept Pathol, Harbin, Peoples R China
7.Capital Med Univ, Beijing Friendship Hosp, Dept Pathol, Beijing, Peoples R China
8.Univ Cambridge, Addenbrookes Hosp, Mol Malignancy Lab, Cambridge CB2 2QQ, England
9.Univ Cambridge, Addenbrookes Hosp, Dept Histopathol, Cambridge CB2 2QQ, England

Recommended Citation:
Yu, Ran,Chen, Gang,Zhou, Chunju,et al. Extra copies of ALK gene locus is a recurrent genetic aberration and favorable prognostic factor in both ALK-positive and ALK-negative anaplastic large cell lymphomas[J]. LEUKEMIA RESEARCH,2012,36(9):1141-1146.
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