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学科主题临床医学
Non-steroidal anti-inflammatory drug use and the risk of gastric cancer: A systematic review and meta-analysis
Wang, WH; Huang, JQ; Zheng, GF; Lam, SK; Karlberg, J; Wong, BCY
刊名JOURNAL OF THE NATIONAL CANCER INSTITUTE
2003-12-03
DOI10.1093/jnci/djg106
95期:23页:1784-1791
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]HELICOBACTER-PYLORI INFECTION ; COLORECTAL-CANCER ; RHEUMATOID-ARTHRITIS ; ASPIRIN USE ; REDUCED RISK ; LARGE-BOWEL ; CYCLOOXYGENASE-2 EXPRESSION ; HEPATOCELLULAR-CARCINOMA ; GASTROINTESTINAL CANCER ; CELL-CYCLE
英文摘要

Background: The relationship between the use of non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin, and the risk of gastric cancer has not been well studied. We performed a systematic review and meta-analysis of published studies to evaluate the association between use of this class of drugs and the risk of gastric cancer. Methods: A fully recursive literature search to January 2003 was conducted in MEDLINE, PubMed, and CANCERLIT to identify potentially relevant case-control or cohort studies. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were calculated under a random-effects model. Results: Nine studies (eight case-control and one cohort) with a total of 2831 gastric cancer case patients were identified. NSAID use was associated with a reduced risk of gastric cancer, with a summary odds ratio of 0.78 (95% CI = 0.69 to 0.87). Users of aspirin (OR = 0.73, 95% CI = 0.63 to 0.86) and non-aspirin NSAIDs (OR = 0.74, 95% CI = 0.55 to 1.00) experienced similar magnitudes of risk reduction. Regular users of NSAIDs (OR = 0.57, 95% CI = 0.44 to 0.74) experienced a lower risk of gastric cancer relative to nonusers than did irregular users (OR = 0.76, 95% CI = 0.62 to 0.94; P = .09 versus regular users). A stratified analysis showed that NSAID use was associated with a statistically significant reduction in risk of noncardia gastric cancer (OR = 0.72, 95% CI = 0.58 to 0.89), but not of gastric cancer at the cardia (OR = 0.80, 95% CI = 0.53 to 1.20). There was no evidence that study design or type of control subject substantially influenced the estimate of effects. Conclusion: NSAID use was associated with a decreased risk of gastric cancer in a dose-dependent manner. This finding warrants proper clinical trials in populations with high risk of gastric cancer.

语种英语
WOS记录号WOS:000187080700012
引用统计
被引频次:175[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55546
专题北京大学第一临床医学院_消化科
作者单位1.Univ Hong Kong, Fac Med, Dept Med, Hong Kong, Hong Kong, Peoples R China
2.Univ Hong Kong, Fac Med, Clin Trials Ctr, Hong Kong, Hong Kong, Peoples R China
3.Peking Univ, Hosp 1, Dept Gastroenterol, Beijing 100871, Peoples R China
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GB/T 7714
Wang, WH,Huang, JQ,Zheng, GF,et al. Non-steroidal anti-inflammatory drug use and the risk of gastric cancer: A systematic review and meta-analysis[J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE,2003,95(23):1784-1791.
APA Wang, WH,Huang, JQ,Zheng, GF,Lam, SK,Karlberg, J,&Wong, BCY.(2003).Non-steroidal anti-inflammatory drug use and the risk of gastric cancer: A systematic review and meta-analysis.JOURNAL OF THE NATIONAL CANCER INSTITUTE,95(23),1784-1791.
MLA Wang, WH,et al."Non-steroidal anti-inflammatory drug use and the risk of gastric cancer: A systematic review and meta-analysis".JOURNAL OF THE NATIONAL CANCER INSTITUTE 95.23(2003):1784-1791.
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