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学科主题: 临床医学
题名:
Reconstitution of natural killer cell receptor repertoires after unmanipulated HLA-mismatched/haploidentical blood and marrow transplantation: Analyses of CD94 : NKG2A and killer immunoglobulin-like receptor expression and their associations with clinical outcome
作者: Zhao, Xiang-Yu; Huang, Xiao-Jun; Liu, Kai-Yan; Xu, Lan-Ping; Liu, Dai-Hong
关键词: HLA-mismatched ; haploidentical ; HSCT ; GVHD ; KIRs ; CD94 : NKG2A
刊名: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
发表日期: 2007-06-01
DOI: 10.1016/j.bbmt.2007.02.010
卷: 13, 期:6, 页:734-744
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Immunology ; Transplantation
研究领域[WOS]: Hematology ; Immunology ; Transplantation
关键词[WOS]: KIR LIGAND INCOMPATIBILITY ; UNRELATED DONOR TRANSPLANTATION ; T-CELLS ; ALLOREACTIVITY ; GRAFT ; RECIPIENTS ; DEPLETION
英文摘要:

The effect of natural killer (NK) cell alloreactivity on the outcome of haploidentical hematopoietic stem cell transplantation (HSCT), with or without in vitro T cell depletion, remains controversial. Killer immunoglobulin-like receptors (KIRs) recognize human leukocyte antigen C and B epitopes on target cells, thereby regulating NK cell activity. To examine the recovery of CD94:NKG2A and KIR (CD158a, CD158b, and CD158e) expression by NK cells, we used flow cytometry to evaluate samples from 24 patients and their donors before and in the year following unmanipulated HLA-haploidentical/mismatched blood and marrow transplantation. Linear regression analysis demonstrated that NKG2A recovery was inversely correlated with CD158b recovery in the year following transplant. The doses of T cell subgroups CD4(+) and CD8(+) were inversely associated with CD158a and CD158e expression during the 2 months following transplantation. Moreover, patients with grades II-IV acute graft-versus-host disease (aGVHD) or who received "high" doses of T cells (>1.37 x 10(8)/kg) showed delayed recov E onths following transplantation. Univariate analysis showed that patients with high CD94 expression by day 60 (>90%) or who received donors with high CD94 expression (>80%) were associated with higher transplantation-related mortality (P = .006 or .067, respectively) and poorer leukemia-free survival (P = .0 12 or .094, respectively). Thus, the occurrence of aGVHD or the receipt of high doses of T cells in the allograft altered KIR reconstitution. Furthermore, high levels of CD94 expression in donors or in recipients by day 60 might be a good predictor for poor prognosis. (C) 2007 American Society for Blood and Marrow Transplantation.

语种: 英语
WOS记录号: WOS:000247425600013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55549
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Peking Univ, Inst Hematol, Peking Univ Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Zhao, Xiang-Yu,Huang, Xiao-Jun,Liu, Kai-Yan,et al. Reconstitution of natural killer cell receptor repertoires after unmanipulated HLA-mismatched/haploidentical blood and marrow transplantation: Analyses of CD94 : NKG2A and killer immunoglobulin-like receptor expression and their associations with clinical outcome[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,2007,13(6):734-744.
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