IR@PKUHSC  > 北京大学第二临床医学院  > 血液科
学科主题临床医学
Reconstitution of natural killer cell receptor repertoires after unmanipulated HLA-mismatched/haploidentical blood and marrow transplantation: Analyses of CD94 : NKG2A and killer immunoglobulin-like receptor expression and their associations with clinical outcome
Zhao, Xiang-Yu; Huang, Xiao-Jun; Liu, Kai-Yan; Xu, Lan-Ping; Liu, Dai-Hong
关键词Hla-mismatched Haploidentical Hsct Gvhd Kirs Cd94 : Nkg2a
刊名BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
2007-06-01
DOI10.1016/j.bbmt.2007.02.010
13期:6页:734-744
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Immunology ; Transplantation
研究领域[WOS]Hematology ; Immunology ; Transplantation
关键词[WOS]KIR LIGAND INCOMPATIBILITY ; UNRELATED DONOR TRANSPLANTATION ; T-CELLS ; ALLOREACTIVITY ; GRAFT ; RECIPIENTS ; DEPLETION
英文摘要

The effect of natural killer (NK) cell alloreactivity on the outcome of haploidentical hematopoietic stem cell transplantation (HSCT), with or without in vitro T cell depletion, remains controversial. Killer immunoglobulin-like receptors (KIRs) recognize human leukocyte antigen C and B epitopes on target cells, thereby regulating NK cell activity. To examine the recovery of CD94:NKG2A and KIR (CD158a, CD158b, and CD158e) expression by NK cells, we used flow cytometry to evaluate samples from 24 patients and their donors before and in the year following unmanipulated HLA-haploidentical/mismatched blood and marrow transplantation. Linear regression analysis demonstrated that NKG2A recovery was inversely correlated with CD158b recovery in the year following transplant. The doses of T cell subgroups CD4(+) and CD8(+) were inversely associated with CD158a and CD158e expression during the 2 months following transplantation. Moreover, patients with grades II-IV acute graft-versus-host disease (aGVHD) or who received "high" doses of T cells (>1.37 x 10(8)/kg) showed delayed recovery of KIRs during the 2 months following transplantation. Univariate analysis showed that patients with high CD94 expression by day 60 (>90%) or who received donors with high CD94 expression (>80%) were associated with higher transplantation-related mortality (P = .006 or .067, respectively) and poorer leukemia-free survival (P = .0 12 or .094, respectively). Thus, the occurrence of aGVHD or the receipt of high doses of T cells in the allograft altered KIR reconstitution. Furthermore, high levels of CD94 expression in donors or in recipients by day 60 might be a good predictor for poor prognosis. (C) 2007 American Society for Blood and Marrow Transplantation.

语种英语
WOS记录号WOS:000247425600013
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55549
专题北京大学第二临床医学院_血液科
作者单位Peking Univ, Inst Hematol, Peking Univ Peoples Hosp, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Xiang-Yu,Huang, Xiao-Jun,Liu, Kai-Yan,et al. Reconstitution of natural killer cell receptor repertoires after unmanipulated HLA-mismatched/haploidentical blood and marrow transplantation: Analyses of CD94 : NKG2A and killer immunoglobulin-like receptor expression and their associations with clinical outcome[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,2007,13(6):734-744.
APA Zhao, Xiang-Yu,Huang, Xiao-Jun,Liu, Kai-Yan,Xu, Lan-Ping,&Liu, Dai-Hong.(2007).Reconstitution of natural killer cell receptor repertoires after unmanipulated HLA-mismatched/haploidentical blood and marrow transplantation: Analyses of CD94 : NKG2A and killer immunoglobulin-like receptor expression and their associations with clinical outcome.BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,13(6),734-744.
MLA Zhao, Xiang-Yu,et al."Reconstitution of natural killer cell receptor repertoires after unmanipulated HLA-mismatched/haploidentical blood and marrow transplantation: Analyses of CD94 : NKG2A and killer immunoglobulin-like receptor expression and their associations with clinical outcome".BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 13.6(2007):734-744.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhao, Xiang-Yu]的文章
[Huang, Xiao-Jun]的文章
[Liu, Kai-Yan]的文章
百度学术
百度学术中相似的文章
[Zhao, Xiang-Yu]的文章
[Huang, Xiao-Jun]的文章
[Liu, Kai-Yan]的文章
必应学术
必应学术中相似的文章
[Zhao, Xiang-Yu]的文章
[Huang, Xiao-Jun]的文章
[Liu, Kai-Yan]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。