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Lumbricus extract promotes the regeneration of injured peripheral nerve in rats
Wei, Shaoyin; Yin, Xiaofeng; Kou, Yuhui; Jiang, Baoguo
关键词Lumbricus Nerve Regeneration Peripheral Nerve Injury Motor Function Recovery
刊名JOURNAL OF ETHNOPHARMACOLOGY
2009-05-04
DOI10.1016/j.jep.2009.02.030
123期:1页:51-54
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
关键词[WOS]EARTHWORM EISENIA-FOETIDA ; WALKING TRACK ANALYSIS ; SCIATIC-NERVE ; ADULT RATS ; RECOVERY ; G-90
英文摘要

Background: Earthworms regenerate amputated parts of their body if the nervous system is intact. Lumbricus is one traditional Chinese medicine (TCM), which has been used in China to promote nerve function for hundreds of years.

Aim of the study: To investigate the beneficial effect of lumbricus extract on peripheral nerve regeneration in rats.

Materials and methods: Nerve function was surgically impaired in Sprague-Dawley (SD) rats by clamping of the left sciatic nerve. The sham-operated group (surgery but no sciatic nerve clamping), control group, and treatment group were treated with 2 ml 0.9% NaCl, 0.9% NaCl, and lumbricus extract (1 g/ml), respectively. Treatments were administered once daily after the operation for 6 weeks. During this period, motor function was monitored by walking track analysis, conduction function of injured sciatic nerve was monitored by electrophysiology, and regeneration of myelinated nerve was assessed by immunohistochemistry.

Results: (1) For nerve function index value, treatment group is higher than control group. (2) For conduction velocity of injured sciatic nerve, treatment group is higher than control group at week 3 and 6. (3) For the number of regenerated myelinated nerve fibers, treatment group is higher than control group at week 2 and 6.

Conclusions: Lumbricus extract appears to enhance sciatic nerve regeneration and function recovery following injury, suggesting the clinical potential of lumbricus extract on the treatment of peripheral nerve injury in humans. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000266124600009
项目编号30625036 ; 2003CB515306
资助机构Chinese National Natural Science Fund for the Outstanding Youth ; Chinese National 973 Project
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55552
专题北京大学第二临床医学院
北京大学第二临床医学院_党委院长办公室
作者单位Peking Univ, Peoples Hosp, Dept Orthoped & Trauma, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Wei, Shaoyin,Yin, Xiaofeng,Kou, Yuhui,et al. Lumbricus extract promotes the regeneration of injured peripheral nerve in rats[J]. JOURNAL OF ETHNOPHARMACOLOGY,2009,123(1):51-54.
APA Wei, Shaoyin,Yin, Xiaofeng,Kou, Yuhui,&Jiang, Baoguo.(2009).Lumbricus extract promotes the regeneration of injured peripheral nerve in rats.JOURNAL OF ETHNOPHARMACOLOGY,123(1),51-54.
MLA Wei, Shaoyin,et al."Lumbricus extract promotes the regeneration of injured peripheral nerve in rats".JOURNAL OF ETHNOPHARMACOLOGY 123.1(2009):51-54.
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