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学科主题: 临床医学
题名:
Lumbricus extract promotes the regeneration of injured peripheral nerve in rats
作者: Wei, Shaoyin; Yin, Xiaofeng; Kou, Yuhui; Jiang, Baoguo
关键词: Lumbricus ; Nerve regeneration ; Peripheral nerve injury ; Motor function recovery
刊名: JOURNAL OF ETHNOPHARMACOLOGY
发表日期: 2009-05-04
DOI: 10.1016/j.jep.2009.02.030
卷: 123, 期:1, 页:51-54
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
关键词[WOS]: EARTHWORM EISENIA-FOETIDA ; WALKING TRACK ANALYSIS ; SCIATIC-NERVE ; ADULT RATS ; RECOVERY ; G-90
英文摘要:

Background: Earthworms regenerate amputated parts of their body if the nervous system is intact. Lumbricus is one traditional Chinese medicine (TCM), which has been used in China to promote nerve function for hundreds of years.

Aim of the study: To investigate the beneficial effect of lumbricus extract on peripheral nerve regeneration in rats.

Materials and methods: Nerve function was surgically impaired in Sprague-Dawley (SD) rats by clamping of the left sciatic nerve. The sham-operated group (surgery but no sciatic nerve clamping), control group, and treatment group were treated with 2 ml 0.9% NaCl, 0.9% NaCl, and lumbricus extract (1 g/ml), respectively. Treatments were administered once daily after the operation for 6 weeks. During this period, motor function was monitored by walking track analysis, conduction function of injured sciatic nerve was monitored by electrophysiology, and regeneration of myelinated nerve was assessed by immunohistochemistry.

Results: (1) For nerve function index value, treatment group is higher than control group. (2) For conduction velocity of injured sciatic nerve, treatment group is higher than control group at week 3 and 6. (3) For the number of regenerated myelinated nerve fibers, treatment group is higher than control group at week 2 and 6.

Conclusions: Lumbricus extract appears to enhance sciatic nerve regeneration and function recovery following injury, suggesting the clinical potential of lumbricus extract on the treatment of peripheral nerve injury in humans. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 30625036 ; 2003CB515306
项目资助者: Chinese National Natural Science Fund for the Outstanding Youth ; Chinese National 973 Project
WOS记录号: WOS:000266124600009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55552
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Orthoped & Trauma, Beijing 100044, Peoples R China

Recommended Citation:
Wei, Shaoyin,Yin, Xiaofeng,Kou, Yuhui,et al. Lumbricus extract promotes the regeneration of injured peripheral nerve in rats[J]. JOURNAL OF ETHNOPHARMACOLOGY,2009,123(1):51-54.
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