|Lumbricus extract promotes the regeneration of injured peripheral nerve in rats|
|Wei, Shaoyin; Yin, Xiaofeng; Kou, Yuhui; Jiang, Baoguo|
|关键词||Lumbricus Nerve Regeneration Peripheral Nerve Injury Motor Function Recovery|
|刊名||JOURNAL OF ETHNOPHARMACOLOGY|
|WOS标题词||Science & Technology|
|类目[WOS]||Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy|
|研究领域[WOS]||Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine|
|关键词[WOS]||EARTHWORM EISENIA-FOETIDA ; WALKING TRACK ANALYSIS ; SCIATIC-NERVE ; ADULT RATS ; RECOVERY ; G-90|
Background: Earthworms regenerate amputated parts of their body if the nervous system is intact. Lumbricus is one traditional Chinese medicine (TCM), which has been used in China to promote nerve function for hundreds of years.
Aim of the study: To investigate the beneficial effect of lumbricus extract on peripheral nerve regeneration in rats.
Materials and methods: Nerve function was surgically impaired in Sprague-Dawley (SD) rats by clamping of the left sciatic nerve. The sham-operated group (surgery but no sciatic nerve clamping), control group, and treatment group were treated with 2 ml 0.9% NaCl, 0.9% NaCl, and lumbricus extract (1 g/ml), respectively. Treatments were administered once daily after the operation for 6 weeks. During this period, motor function was monitored by walking track analysis, conduction function of injured sciatic nerve was monitored by electrophysiology, and regeneration of myelinated nerve was assessed by immunohistochemistry.
Results: (1) For nerve function index value, treatment group is higher than control group. (2) For conduction velocity of injured sciatic nerve, treatment group is higher than control group at week 3 and 6. (3) For the number of regenerated myelinated nerve fibers, treatment group is higher than control group at week 2 and 6.
Conclusions: Lumbricus extract appears to enhance sciatic nerve regeneration and function recovery following injury, suggesting the clinical potential of lumbricus extract on the treatment of peripheral nerve injury in humans. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
|项目编号||30625036 ; 2003CB515306|
|资助机构||Chinese National Natural Science Fund for the Outstanding Youth ; Chinese National 973 Project|
|作者单位||Peking Univ, Peoples Hosp, Dept Orthoped & Trauma, Beijing 100044, Peoples R China|
|Wei, Shaoyin,Yin, Xiaofeng,Kou, Yuhui,et al. Lumbricus extract promotes the regeneration of injured peripheral nerve in rats[J]. JOURNAL OF ETHNOPHARMACOLOGY,2009,123(1):51-54.|
|APA||Wei, Shaoyin,Yin, Xiaofeng,Kou, Yuhui,&Jiang, Baoguo.(2009).Lumbricus extract promotes the regeneration of injured peripheral nerve in rats.JOURNAL OF ETHNOPHARMACOLOGY,123(1),51-54.|
|MLA||Wei, Shaoyin,et al."Lumbricus extract promotes the regeneration of injured peripheral nerve in rats".JOURNAL OF ETHNOPHARMACOLOGY 123.1(2009):51-54.|