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Phosphodiesterase-5 Expression and Function in the Lower Urinary Tract: A Critical Review
Lin, Ching-Shwun; Albersen, Maarten; Xin, Zhongcheng; Namiki, Mikio; Muller, Dieter; Lue, Tom F.
刊名UROLOGY
2013-03-01
DOI10.1016/j.urology.2012.11.028
81期:3页:480-487
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
资助者National Institutes of Health ; National Institutes of Health
研究领域[WOS]Urology & Nephrology
关键词[WOS]BENIGN PROSTATIC HYPERPLASIA ; GUINEA-PIG BLADDER ; CYCLIC-NUCLEOTIDE LEVELS ; CAVERNOUS SMOOTH-MUSCLE ; SYMPTOMS SECONDARY ; ERECTILE DYSFUNCTION ; SILDENAFIL CITRATE ; IN-VITRO ; INDUCED RELAXATION ; CORPUS CAVERNOSUM
英文摘要

Both clinical and preclinical studies have mostly shown beneficial effects for Phosphodiesterase-5 (PDE-5) inhibitors in the treatment of lower urinary tract symptoms. Molecular studies have consistently shown abundant PDE-5 expression in bladder smooth muscle. Data concerning urethral PDE-5 expression have been surprising because striated muscle was not only positively identified, but also found to express more PDE-5 than the smooth muscle. In the prostate, highly variable results have been obtained. For PDE-5 expression, the data have ranged from extremely low to highly abundant. PDE-5 has been found in the glandular epithelium, vascular smooth muscle, endothelium, and fibromuscular stroma. UROLOGY 81: 480-487, 2013. (C) 2013 Elsevier Inc.

语种英语
所属项目编号DK045370 ; DK64538 ; DK069655
资助者National Institutes of Health ; National Institutes of Health
WOS记录号WOS:000315530800004
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55554
专题北京大学第一临床医学院_男科中心
作者单位1.Peking Univ, Androl Ctr, Hosp 1, Beijing 100871, Peoples R China
2.Univ Calif San Francisco, Dept Urol, Sch Med, Knuppe Mol Urol Lab, San Francisco, CA 94143 USA
3.Katholieke Univ Leuven Hosp, Dept Urol, Louvain, Belgium
4.Kanazawa Univ, Grad Sch Med Sci, Dept Integrat Canc Therapy & Urol, Kanazawa, Ishikawa, Japan
5.Univ Giessen, Inst Anat & Cell Biol, D-35390 Giessen, Germany
推荐引用方式
GB/T 7714
Lin, Ching-Shwun,Albersen, Maarten,Xin, Zhongcheng,et al. Phosphodiesterase-5 Expression and Function in the Lower Urinary Tract: A Critical Review[J]. UROLOGY,2013,81(3):480-487.
APA Lin, Ching-Shwun,Albersen, Maarten,Xin, Zhongcheng,Namiki, Mikio,Muller, Dieter,&Lue, Tom F..(2013).Phosphodiesterase-5 Expression and Function in the Lower Urinary Tract: A Critical Review.UROLOGY,81(3),480-487.
MLA Lin, Ching-Shwun,et al."Phosphodiesterase-5 Expression and Function in the Lower Urinary Tract: A Critical Review".UROLOGY 81.3(2013):480-487.
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