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学科主题: 临床医学
题名:
Phosphodiesterase-5 Expression and Function in the Lower Urinary Tract: A Critical Review
作者: Lin, Ching-Shwun; Albersen, Maarten; Xin, Zhongcheng; Namiki, Mikio; Muller, Dieter; Lue, Tom F.
刊名: UROLOGY
发表日期: 2013-03-01
DOI: 10.1016/j.urology.2012.11.028
卷: 81, 期:3, 页:480-487
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: BENIGN PROSTATIC HYPERPLASIA ; GUINEA-PIG BLADDER ; CYCLIC-NUCLEOTIDE LEVELS ; CAVERNOUS SMOOTH-MUSCLE ; SYMPTOMS SECONDARY ; ERECTILE DYSFUNCTION ; SILDENAFIL CITRATE ; IN-VITRO ; INDUCED RELAXATION ; CORPUS CAVERNOSUM
英文摘要:

Both clinical and preclinical studies have mostly shown beneficial effects for Phosphodiesterase-5 (PDE-5) inhibitors in the treatment of lower urinary tract symptoms. Molecular studies have consistently shown abundant PDE-5 expression in bladder smooth muscle. Data concerning urethral PDE-5 expression have been surprising because striated muscle was not only positively identified, but also found to express more PDE-5 than the smooth muscle. In the prostate, highly variable results have been obtained. For PDE-5 expression, the data have ranged from extremely low to highly abundant. PDE-5 has been found in the glandular epithelium, vascular smooth muscle, endothelium, and fibromuscular stroma. UROLOGY 81: 480-487, 2013. (C) 2013 Elsevier Inc.

语种: 英语
所属项目编号: DK045370 ; DK64538 ; DK069655
项目资助者: National Institutes of Health
WOS记录号: WOS:000315530800004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55554
Appears in Collections:北京大学第一临床医学院_男科中心_期刊论文

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作者单位: 1.Peking Univ, Androl Ctr, Hosp 1, Beijing 100871, Peoples R China
2.Univ Calif San Francisco, Dept Urol, Sch Med, Knuppe Mol Urol Lab, San Francisco, CA 94143 USA
3.Katholieke Univ Leuven Hosp, Dept Urol, Louvain, Belgium
4.Kanazawa Univ, Grad Sch Med Sci, Dept Integrat Canc Therapy & Urol, Kanazawa, Ishikawa, Japan
5.Univ Giessen, Inst Anat & Cell Biol, D-35390 Giessen, Germany

Recommended Citation:
Lin, Ching-Shwun,Albersen, Maarten,Xin, Zhongcheng,et al. Phosphodiesterase-5 Expression and Function in the Lower Urinary Tract: A Critical Review[J]. UROLOGY,2013,81(3):480-487.
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