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学科主题基础医学
Toll-like receptors and cytokines/cytokine receptors polymorphisms associate with non-response to hepatitis B vaccine
Chen, Jie1; Liang, Zhenglun2; Lu, Fengmin1; Fang, Xin2; Liu, Shuang3; Zeng, Ying4; Zhu, Fengcai5; Chen, Xiangmei1; Shen, Tao1; Li, Jie1; Zhuang, Hui1
关键词Polymorphisms Hepatitis B vaccine Toll-like receptors Cytokines Cytokine receptors Non-responder
刊名VACCINE
2011-01-17
DOI10.1016/j.vaccine.2010.11.023
29期:4页:706-711
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology ; Medicine, Research & Experimental
研究领域[WOS]Immunology ; Research & Experimental Medicine
关键词[WOS]VIRUS-INFECTION ; GENE POLYMORPHISMS ; HYPERENDEMIC AREA ; ANTIBODY-RESPONSE ; HBSAG VACCINATION ; IMMUNE-RESPONSES ; SURFACE-ANTIGEN ; CELL CLONES ; CHILDREN ; IMMUNOGENICITY
英文摘要

It is well documented that 5-10% hepatitis B adult vaccinees are non- and hypo-responders and probably are not adequately protected against hepatitis B virus (HBV) infection. The sequence variations of genes involved in processes such as pathogen recognition, antigen processing and presentation, and differentiation/maturation of lymphocytes may affect the duration and intensity of protective humoral immune response to the hepatitis B vaccine. In this study, frequencies of 53 known SNPs within 21 candidate genes were analyzed among 46 responders and 24 non-responders. Four SNPs (rs2243248, rs1805015, rs1295686 and rs3804100) in IL-4, IL-4RA, IL-13 and TLR2 genes were found significantly associated with the vaccinees′ status of serum anti-HBV response triggered by the vaccine (P<0.05). Two SNPs (rs1295686 and rs1805015) also showed significant association with the vaccine-induced immune response when analyzed together with risk factors such as age and gender, by multivariable logistic regression analysis (P<0.05). Further, haplotype analysis showed that the AG haplotype defined by SNPs rs1143633 (IL-1B; intron) and rs1143627 (IL-1B; intron) was present more frequently in non-responders than in responders (P=0.035). Thus, specific SNPs in genes of cytokines/cytokine receptors and TLR2 were associated with status of the hepatitis B vaccine-induced protective humoral immune response. (C) 2010 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000286853500016
项目编号2008ZX10002-001 ; 2009ZX10004-903 ; 2009ZX10004-802
资助机构National Key Science and Technology Projects
引用统计
被引频次:38[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55555
专题北京大学基础医学院_病原生物学系
北京大学基础医学院
北京大学第一临床医学院_口腔科
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100191, Peoples R China
2.Natl Inst Control Pharmaceut & Biol Prod, Div Viral Vaccines 2, Beijing 100050, Peoples R China
3.Capital Med Univ, Beijing Artificial Liver Treatment & Training Ctr, Beijing Youan Hosp, Beijing 100069, Peoples R China
4.Shenzhen Kangtai Biol Prod Co Ltd, Dept Vaccine Res, Shenzhen 518057, Guangdong, Peoples R China
5.Jiangsu Prov Ctr Dis Prevent & Control, Nanjing 210009, Jiangsu, Peoples R China
推荐引用方式
GB/T 7714
Chen, Jie,Liang, Zhenglun,Lu, Fengmin,et al. Toll-like receptors and cytokines/cytokine receptors polymorphisms associate with non-response to hepatitis B vaccine[J]. VACCINE,2011,29(4):706-711.
APA Chen, Jie.,Liang, Zhenglun.,Lu, Fengmin.,Fang, Xin.,Liu, Shuang.,...&Zhuang, Hui.(2011).Toll-like receptors and cytokines/cytokine receptors polymorphisms associate with non-response to hepatitis B vaccine.VACCINE,29(4),706-711.
MLA Chen, Jie,et al."Toll-like receptors and cytokines/cytokine receptors polymorphisms associate with non-response to hepatitis B vaccine".VACCINE 29.4(2011):706-711.
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