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学科主题: 基础医学
题名:
Toll-like receptors and cytokines/cytokine receptors polymorphisms associate with non-response to hepatitis B vaccine
作者: Chen, Jie1; Liang, Zhenglun2; Lu, Fengmin1; Fang, Xin2; Liu, Shuang3; Zeng, Ying4; Zhu, Fengcai5; Chen, Xiangmei1; Shen, Tao1; Li, Jie1; Zhuang, Hui1
关键词: Polymorphisms ; Hepatitis B vaccine ; Toll-like receptors ; Cytokines ; Cytokine receptors ; Non-responder
刊名: VACCINE
发表日期: 2011-01-17
DOI: 10.1016/j.vaccine.2010.11.023
卷: 29, 期:4, 页:706-711
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology ; Medicine, Research & Experimental
研究领域[WOS]: Immunology ; Research & Experimental Medicine
关键词[WOS]: VIRUS-INFECTION ; GENE POLYMORPHISMS ; HYPERENDEMIC AREA ; ANTIBODY-RESPONSE ; HBSAG VACCINATION ; IMMUNE-RESPONSES ; SURFACE-ANTIGEN ; CELL CLONES ; CHILDREN ; IMMUNOGENICITY
英文摘要:

It is well documented that 5-10% hepatitis B adult vaccinees are non- and hypo-responders and probably are not adequately protected against hepatitis B virus (HBV) infection. The sequence variations of genes involved in processes such as pathogen recognition, antigen processing and presentation, and differentiation/maturation of lymphocytes may affect the duration and intensity of protective humoral immune response to the hepatitis B vaccine. In this study, frequencies of 53 known SNPs within 21 candidate genes were analyzed among 46 responders and 24 non-responders. Four SNPs (rs2243248, rs1805015, rs1295686 and rs3804100) in IL-4, IL-4RA, IL-13 and TLR2 genes were found significantly associated with the vaccinees′ status of serum anti-HBV response triggered by the vaccine (P<0.05). Two SNPs (rs1295686 and rs1805015) also showed significant association with the vaccine-induced immune response when analyzed together with risk factors such as age and gender, by multivariable logistic regression analysis (P<0.05). Further, haplotype analysis showed that the AG haplotype defined by SNPs rs1143633 (IL-1B; intron) and rs1143627 (IL-1B; intron) was present more frequently in non-responders than in responders (P=0.035). Thus, specific SNPs in genes of cytokines/cytokine receptors and TLR2 were associated with status of the hepatitis B vaccine-induced protective humoral immune response. (C) 2010 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2008ZX10002-001 ; 2009ZX10004-903 ; 2009ZX10004-802
项目资助者: National Key Science and Technology Projects
WOS记录号: WOS:000286853500016
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55555
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100191, Peoples R China
2.Natl Inst Control Pharmaceut & Biol Prod, Div Viral Vaccines 2, Beijing 100050, Peoples R China
3.Capital Med Univ, Beijing Artificial Liver Treatment & Training Ctr, Beijing Youan Hosp, Beijing 100069, Peoples R China
4.Shenzhen Kangtai Biol Prod Co Ltd, Dept Vaccine Res, Shenzhen 518057, Guangdong, Peoples R China
5.Jiangsu Prov Ctr Dis Prevent & Control, Nanjing 210009, Jiangsu, Peoples R China

Recommended Citation:
Chen, Jie,Liang, Zhenglun,Lu, Fengmin,et al. Toll-like receptors and cytokines/cytokine receptors polymorphisms associate with non-response to hepatitis B vaccine[J]. VACCINE,2011,29(4):706-711.
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