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学科主题: 临床医学
题名:
Effect of p53 codon 72 genotype on breast cancer survival depends on p53 gene status
作者: Xu, Ye1; Yao, Lihua1; Zhao, Ailian2; Ouyang, Tao1; Li, Jinfeng1; Wang, Tianfeng1; Fan, Zhaoqing1; Fan, Tie1; Lin, Benyao1; Lu, Youyong3; Xie, Yuntao1
关键词: breast cancer ; p53 codon 72 ; p53 mutation ; survival
刊名: INTERNATIONAL JOURNAL OF CANCER
发表日期: 2008-06-15
DOI: 10.1002/ijc.23454
卷: 122, 期:12, 页:2761-2766
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: CELL LUNG-CARCINOMA ; POLYMORPHIC VARIANTS ; PROGNOSTIC VALUE ; TP53 MUTATIONS ; GASTRIC-CANCER ; ASSOCIATION ; CHEMOTHERAPY ; THERAPY ; RISK ; P73
英文摘要:

In vitro studies suggest that p53 codon 72 genotype alters the apoptotic capacity of p53 protein, with the 72 arginine (R) form of wild-type p53 harboring a greater apoptosis-inducing potential than the 72 proline (P) variant. The aim of this study was to investigate whether the association between the p53 codon 72 genotype and breast cancer survival was modified by p53 gene status. In our study, we examined the p53 codon 72 genotype and p53 mutations (through exons 4-9) in paraffin-embedded specimens from 414 breast cancer patients with a median follow-up of 8.2 years. We report that the p53 codon 72 genotype was significantly associated with disease-free survival (DFS, p = 0.02) but not with disease-specific survival (DSS, p = 0.24) in the entire study population (n = 414). In contrast, the codon 72 genotype was strongly associated with both DFS (p = 0.001) and DSS (p = 0.04) among patients with a wild-type p53 tumor (n = 346), patients with the P/P variant had worse DFS and DSS than did those with the P/R or R/R variant in this subgroup of patients. More importantly, as compared with the P/R or R/R variant, the P/P variant remained an independent prognostic factor of DFS among patients with a wild-type p53 tumor (HR = 2.5; 95%CI = 1.4-4.4; p = 0.003). We conclude that the effect of p53 codon 72 genotype on breast cancer survival is dependent on p53 gene status, the P/P variant is strongly associated with poor prognosis among patients with a wild-type p53 tumor. (C) 2008 Wiley-Liss, Inc.

语种: 英语
WOS记录号: WOS:000256713800014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55559
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Beijing Canc Hosp & Inst, Sch Oncol, Breast Ctr, Beijing 100036, Peoples R China
2.Peking Univ, Beijing Canc Hosp & Inst, Sch Oncol, Dept Pathol, Beijing 100036, Peoples R China
3.Peking Univ, Beijing Canc Hosp & Inst, Sch Oncol, Mol Oncol Lab, Beijing 100036, Peoples R China

Recommended Citation:
Xu, Ye,Yao, Lihua,Zhao, Ailian,et al. Effect of p53 codon 72 genotype on breast cancer survival depends on p53 gene status[J]. INTERNATIONAL JOURNAL OF CANCER,2008,122(12):2761-2766.
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