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Effect of p53 codon 72 genotype on breast cancer survival depends on p53 gene status
Xu, Ye1; Yao, Lihua1; Zhao, Ailian2; Ouyang, Tao1; Li, Jinfeng1; Wang, Tianfeng1; Fan, Zhaoqing1; Fan, Tie1; Lin, Benyao1; Lu, Youyong3; Xie, Yuntao1
关键词Breast Cancer P53 Codon 72 P53 Mutation Survival
刊名INTERNATIONAL JOURNAL OF CANCER
2008-06-15
DOI10.1002/ijc.23454
122期:12页:2761-2766
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]CELL LUNG-CARCINOMA ; POLYMORPHIC VARIANTS ; PROGNOSTIC VALUE ; TP53 MUTATIONS ; GASTRIC-CANCER ; ASSOCIATION ; CHEMOTHERAPY ; THERAPY ; RISK ; P73
英文摘要

In vitro studies suggest that p53 codon 72 genotype alters the apoptotic capacity of p53 protein, with the 72 arginine (R) form of wild-type p53 harboring a greater apoptosis-inducing potential than the 72 proline (P) variant. The aim of this study was to investigate whether the association between the p53 codon 72 genotype and breast cancer survival was modified by p53 gene status. In our study, we examined the p53 codon 72 genotype and p53 mutations (through exons 4-9) in paraffin-embedded specimens from 414 breast cancer patients with a median follow-up of 8.2 years. We report that the p53 codon 72 genotype was significantly associated with disease-free survival (DFS, p = 0.02) but not with disease-specific survival (DSS, p = 0.24) in the entire study population (n = 414). In contrast, the codon 72 genotype was strongly associated with both DFS (p = 0.001) and DSS (p = 0.04) among patients with a wild-type p53 tumor (n = 346), patients with the P/P variant had worse DFS and DSS than did those with the P/R or R/R variant in this subgroup of patients. More importantly, as compared with the P/R or R/R variant, the P/P variant remained an independent prognostic factor of DFS among patients with a wild-type p53 tumor (HR = 2.5; 95%CI = 1.4-4.4; p = 0.003). We conclude that the effect of p53 codon 72 genotype on breast cancer survival is dependent on p53 gene status, the P/P variant is strongly associated with poor prognosis among patients with a wild-type p53 tumor. (C) 2008 Wiley-Liss, Inc.

语种英语
WOS记录号WOS:000256713800014
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55559
专题北京大学临床肿瘤学院
北京大学临床肿瘤学院_乳腺癌预防治疗中心
北京大学临床肿瘤学院_病理科
北京大学临床肿瘤学院_乳腺中心实验室
作者单位1.Peking Univ, Beijing Canc Hosp & Inst, Sch Oncol, Breast Ctr, Beijing 100036, Peoples R China
2.Peking Univ, Beijing Canc Hosp & Inst, Sch Oncol, Dept Pathol, Beijing 100036, Peoples R China
3.Peking Univ, Beijing Canc Hosp & Inst, Sch Oncol, Mol Oncol Lab, Beijing 100036, Peoples R China
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GB/T 7714
Xu, Ye,Yao, Lihua,Zhao, Ailian,et al. Effect of p53 codon 72 genotype on breast cancer survival depends on p53 gene status[J]. INTERNATIONAL JOURNAL OF CANCER,2008,122(12):2761-2766.
APA Xu, Ye.,Yao, Lihua.,Zhao, Ailian.,Ouyang, Tao.,Li, Jinfeng.,...&Xie, Yuntao.(2008).Effect of p53 codon 72 genotype on breast cancer survival depends on p53 gene status.INTERNATIONAL JOURNAL OF CANCER,122(12),2761-2766.
MLA Xu, Ye,et al."Effect of p53 codon 72 genotype on breast cancer survival depends on p53 gene status".INTERNATIONAL JOURNAL OF CANCER 122.12(2008):2761-2766.
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