|Impact of completeness of revascularization by coronary intervention on exercise capacity early after acute ST-elevation myocardial infarction|
|Zhao, Wei; Bai, Jin; Zhang, Fuchun; Guo, Lijun; Gao, Wei1|
|关键词||Myocardial Infarction Percutaneous Coronary Intervention Angioplasty Revascularization Multivessel Disease Exercise Capacity|
|刊名||JOURNAL OF CARDIOTHORACIC SURGERY|
|WOS标题词||Science & Technology|
|类目[WOS]||Cardiac & Cardiovascular Systems|
|研究领域[WOS]||Cardiovascular System & Cardiology|
|关键词[WOS]||MULTIVESSEL DISEASE ; ARTERY-DISEASE ; ANAEROBIC THRESHOLD ; OXYGEN-UPTAKE ; ANGIOPLASTY ; TRIAL ; MANAGEMENT ; MORTALITY ; SEVERITY ; ISCHEMIA|
Background: The importance of achieving complete revascularization by percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (MI) on exercise capacity remains unclear. Objective: To compare exercise capacity early after acute ST-elevation myocardial infarction (STEMI), in patients receiving PCI with stenting, between those completely revascularized (CR) and those incompletely revascularized (IR).
Methods: We retrospectively reviewed 326 patients [single-vessel disease (SVD) group, 118 patients; multivessel disease (MVD) with CR group, 112 patients; MVD with IR group, 96 patients] who underwent cardiopulmonary exercise testing 7-30 days after STEMI to measure peak oxygen uptake (VO2peak), oxygen uptake at anaerobic threshold (VO2AT), and peak oxygen pulse. Demographic data, presence of concomitant diseases, STEMI characteristics, and echocardiography and angiography findings were evaluated.
Results: Most patients were male (89.0%) and mean age was 55.6 +/- 11.2 years. Ischemic ST deviation occurred in 7.1%, with no significant difference between groups. VO2peak and VO2AT did not differ significantly between groups, despite a trend to be lower in the CR and IR groups compared with the SVD group. Peak oxygen pulse was significantly higher in the SVD group than in the IR group (p = 0.005). After adjustment for age, gender, body mass index, cardiovascular risk factors, MI characteristics and echocardiography parameters, CR was not an independent predictor of VO2peak (OR = -0.123, 95% confidence interval [CI] -2.986 to 0.232, p = 0.093), VO2AT (OR = 0.002, 95% CI 1.735 to 1.773, p = 0.983), or peak oxygen pulse (OR = -0.102, 95% CI -1.435 to 0.105, p = 0.090).
Conclusion: CR in patients with STEMI treated with PCI for multivessel disease might show no benefit on short-term exercise tolerance over IR.
|项目编号||2006BAI01A02 ; 81030001|
|资助机构||National Science & ; Technology Pillar Program ; National Natural Science Foundation of China|
|作者单位||1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China|
2.Peking Univ Third Hosp, Dept Cardiol, Beijing 100191, Peoples R China
3.Minist Hlth, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Beijing 100191, Peoples R China
|Zhao, Wei,Bai, Jin,Zhang, Fuchun,et al. Impact of completeness of revascularization by coronary intervention on exercise capacity early after acute ST-elevation myocardial infarction[J]. JOURNAL OF CARDIOTHORACIC SURGERY,2014,9.|
|APA||Zhao, Wei,Bai, Jin,Zhang, Fuchun,Guo, Lijun,&Gao, Wei.(2014).Impact of completeness of revascularization by coronary intervention on exercise capacity early after acute ST-elevation myocardial infarction.JOURNAL OF CARDIOTHORACIC SURGERY,9.|
|MLA||Zhao, Wei,et al."Impact of completeness of revascularization by coronary intervention on exercise capacity early after acute ST-elevation myocardial infarction".JOURNAL OF CARDIOTHORACIC SURGERY 9(2014).|