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学科主题: 临床医学
题名:
Impact of completeness of revascularization by coronary intervention on exercise capacity early after acute ST-elevation myocardial infarction
作者: Zhao, Wei; Bai, Jin; Zhang, Fuchun; Guo, Lijun; Gao, Wei1
关键词: Myocardial infarction ; Percutaneous coronary intervention ; Angioplasty ; Revascularization ; Multivessel disease ; Exercise capacity
刊名: JOURNAL OF CARDIOTHORACIC SURGERY
发表日期: 2014-03-19
DOI: 10.1186/1749-8090-9-50
卷: 9
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: MULTIVESSEL DISEASE ; ARTERY-DISEASE ; ANAEROBIC THRESHOLD ; OXYGEN-UPTAKE ; ANGIOPLASTY ; TRIAL ; MANAGEMENT ; MORTALITY ; SEVERITY ; ISCHEMIA
英文摘要:

Background: The importance of achieving complete revascularization by percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (MI) on exercise capacity remains unclear. Objective: To compare exercise capacity early after acute ST-elevation myocardial infarction (STEMI), in patients receiving PCI with stenting, between those completely revascularized (CR) and those incompletely revascularized (IR).

Methods: We retrospectively reviewed 326 patients [single-vessel disease (SVD) group, 118 patients; multivessel disease (MVD) with CR group, 112 patients; MVD with IR group, 96 patients] who underwent cardiopulmonary exercise testing 7-30 days after STEMI to measure peak oxygen uptake (VO2peak), oxygen uptake at anaerobic threshold (VO2AT), and peak oxygen pulse. Demographic data, presence of concomitant diseases, STEMI characteristics, and echocardiography and angiography findings were evaluated.

Results: Most patients were male (89.0%) and mean age was 55.6 +/- 11.2 years. Ischemic ST deviation occurred in 7.1%, with no significant difference between groups. VO2peak and VO2AT did not differ significantly between groups, despite a trend to be lower in the CR and IR groups compared with the SVD group. Peak oxygen pulse was significantly higher in the SVD group than in the IR group (p = 0.005). After adjustment for age, gender, body mass index, cardiovascular risk factors, MI characteristics and echocardiography parameters, CR was not an independent predictor of VO2peak (OR = -0.123, 95% confidence interval [CI] -2.986 to 0.232, p = 0.093), VO2AT (OR = 0.002, 95% CI 1.735 to 1.773, p = 0.983), or peak oxygen pulse (OR = -0.102, 95% CI -1.435 to 0.105, p = 0.090).

Conclusion: CR in patients with STEMI treated with PCI for multivessel disease might show no benefit on short-term exercise tolerance over IR.

语种: 英语
所属项目编号: 2006BAI01A02 ; 81030001
项目资助者: National Science &amp ; Technology Pillar Program ; National Natural Science Foundation of China
WOS记录号: WOS:000333393000001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55561
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
2.Peking Univ Third Hosp, Dept Cardiol, Beijing 100191, Peoples R China
3.Minist Hlth, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Beijing 100191, Peoples R China

Recommended Citation:
Zhao, Wei,Bai, Jin,Zhang, Fuchun,et al. Impact of completeness of revascularization by coronary intervention on exercise capacity early after acute ST-elevation myocardial infarction[J]. JOURNAL OF CARDIOTHORACIC SURGERY,2014,9.
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