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Role of IKK/NF-kappa B Signaling in Extinction of Conditioned Place Aversion Memory in Rats
Yang, Cheng-Hao1,4; Liu, Xiang-Ming2; Si, Ji-Jian1,4; Shi, Hai-Shui3; Xue, Yan-Xue3; Liu, Jian-Feng3; Luo, Yi-Xiao3; Chen, Chen3; Li, Peng3; Yang, Jian-Li4; Wu, Ping3; Lu, Lin3
刊名PLOS ONE
2012-06-26
DOI10.1371/journal.pone.0039696
7期:6
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]LONG-TERM-MEMORY ; ANTAGONIST MK-801 BLOCKS ; TRANSCRIPTION FACTOR ; BASOLATERAL AMYGDALA ; SODIUM-BUTYRATE ; IMPAIRS RECONSOLIDATION ; HISTONE MODIFICATION ; SYNAPTIC PLASTICITY ; FEAR EXTINCTION ; SPATIAL MEMORY
英文摘要

The inhibitor kB protein kinase/nuclear factor kB (IKK/NF-kB) signaling pathway is critical for synaptic plasticity. However, the role of IKK/NF-kB in drug withdrawal-associated conditioned place aversion (CPA) memory is unknown. Here, we showed that inhibition of IKK/NF-kB by sulphasalazine (SSZ; 10 mM, i.c.v.) selectively blocked the extinction but not acquisition or expression of morphine-induced CPA in rats. The blockade of CPA extinction induced by SSZ was abolished by sodium butyrate, an inhibitor of histone deacetylase. Thus, the IKK/NF-kB signaling pathway might play a critical role in the extinction of morphine-induced CPA in rats and might be a potential pharmacotherapy target for opiate addiction.

语种英语
WOS记录号WOS:000305808700045
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55562
Collection中国药物依赖性研究所
北京大学医学部管理机构_医学部
北京大学精神卫生研究所_精神科
作者单位1.Tianjin Med Univ, Tianjin, Peoples R China
2.Tianjin Med Univ, Dept Thorac Oncol, Tianjin Canc Inst & Hosp, Tianjin, Peoples R China
3.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China
4.Tianjin Mental Hlth Ctr, Tianjin Inst Mental Hlth, Tianjin, Peoples R China
Recommended Citation
GB/T 7714
Yang, Cheng-Hao,Liu, Xiang-Ming,Si, Ji-Jian,et al. Role of IKK/NF-kappa B Signaling in Extinction of Conditioned Place Aversion Memory in Rats[J]. PLOS ONE,2012,7(6).
APA Yang, Cheng-Hao.,Liu, Xiang-Ming.,Si, Ji-Jian.,Shi, Hai-Shui.,Xue, Yan-Xue.,...&Lu, Lin.(2012).Role of IKK/NF-kappa B Signaling in Extinction of Conditioned Place Aversion Memory in Rats.PLOS ONE,7(6).
MLA Yang, Cheng-Hao,et al."Role of IKK/NF-kappa B Signaling in Extinction of Conditioned Place Aversion Memory in Rats".PLOS ONE 7.6(2012).
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