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学科主题: 临床医学
题名:
Underlying heart disease and microbiological spectrum of adult infective endocarditis in one Chinese university hospital: a 10-year retrospective study
作者: Ma, X. Z.; Li, X. Y.; Que, C. L.; Lv, Y.
关键词: infective endocarditis ; congenital heart disease ; degenerative valvular disease ; rheumatic heart disease ; viridans group streptococcus
刊名: INTERNAL MEDICINE JOURNAL
发表日期: 2013-12-01
DOI: 10.1111/imj.12248
卷: 43, 期:12, 页:1303-1309
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: VIRIDANS GROUP STREPTOCOCCI ; ANTIMICROBIAL SUSCEPTIBILITY ; POPULATION ; MORTALITY ; DIAGNOSIS ; PATTERNS ; FEATURES ; TRENDS ; RISK
英文摘要:

Background and AimTo identify the underlying heart disease and microbiological pathogen associated with infective endocarditis (IE) in Chinese patients in one university hospital over a 10-year period.

MethodsWe recruited 115 adult patients admitted to Peking University First Hospital from 2002 to 2011 who were diagnosed with definite IE. Statistical analysis was performed to analyse data on demographics, clinical and laboratory findings, as well as microbiological pathogens.

ResultsThe most common underlying heart diseases for IE were congenital heart disease (24.3%) followed by degenerative valvular disease (17.4%). Aortic (44.3%) and mitral (43.5%) valves were most frequently affected. The right-sided IE cases were all found in patients with congenital heart disease. The age of patients was younger in right-sided cases than that in left-sided ones (P = 0.001). There was no difference in the mortality among groups with different underlying heart disease (P = 0.841). Forty-four (38.3%) patients were infected with viridans group streptococci. The isolation rate of staphylococci in right-sided IE was higher than that in the left-sided IE group (P = 0.021). More than 85% of streptococci were susceptible to -lactams.

ConclusionsCongenital heart disease and degenerative valvular disease have overtaken rheumatic heart disease as the major underlying heart diseases associated with IE. Viridans group streptococci are the most common microbial cause of IE.

语种: 英语
WOS记录号: WOS:000328138300008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55565
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Antiinfect, Beijing 100871, Peoples R China

Recommended Citation:
Ma, X. Z.,Li, X. Y.,Que, C. L.,et al. Underlying heart disease and microbiological spectrum of adult infective endocarditis in one Chinese university hospital: a 10-year retrospective study[J]. INTERNAL MEDICINE JOURNAL,2013,43(12):1303-1309.
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