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Efficacy and safety of percutaneous microwave coagulation therapy followed by I-125 seed brachytherapy for VX2 hepatic tumors in a rabbit model
Yu, Dong-Sheng1; Chang, Hong2; Sommer, Christof-Matthias3; Qu, Wei-Li1; Xu, Wen-Jian1; Yang, Ren-Jie4; Zhao, Peng1
关键词Liver Cancer Microwave I-125 Seed Computed Tomography Animal Model
刊名EXPERIMENTAL AND THERAPEUTIC MEDICINE
2013-07-01
DOI10.3892/etm.2013.1088
6期:1页:159-163
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]HEPATOCELLULAR-CARCINOMA ; RADIOFREQUENCY ABLATION ; INTERSTITIAL BRACHYTHERAPY ; THERMAL ABLATION ; LIVER-TUMORS ; LUNG-CANCER ; CHEMOEMBOLIZATION ; IMPLANTATION ; COMBINATION ; MANAGEMENT
英文摘要

The aim of this study was to evaluate the efficacy and safety of percutaneous microwave coagulation therapy (PMCT) followed by I-125 seed brachytherapy for VX2 liver cancer in rabbits. Eighty New Zealand rabbits were injected with suspensions of VX2 tumor cells to create an animal model. The rabbits were randomly divided into 4 groups (n=20); the control, PMCT, I-125 seed brachytherapy and combination groups. Group A was treated with PMCT at 40 W for 120 sec, group B was treated with I-125 seed brachytherapy and group C was treated with PMCT followed by I-125 seed brachytherapy. Group D were not treated and served as the control group. At 21 days after treatment, the rabbits were sacrificed for pathological assessment. The complete tumor necrosis rate was 19 out of 20 tumors (95%) in group C, 6 (30%) in group A, 0 (0%) in group B and 0 (0%) in the control group. The complete tumor necrosis rate was observed to be significantly different between groups C and A, and between groups C and B (P<0.01). No intraheptic metastasis occurred in group C, compared with an incidence of 7 (35%) in group A, 2(10%) in group B and 20 (100%) in the control group. Between groups C and A, and between groups C and D, the intraheptic metastasis rate was statistically significant (P<0.01). PMCT followed by I-125 seed brachytherapy increased the rate of carcinoma necrosis and decreased carcinoma metastasis in the VX2 rabbit model. This combined treatment is a safe, effective and minimally invasive therapeutic option for liver cancer.

语种英语
WOS记录号WOS:000321078900030
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55569
专题北京大学临床肿瘤学院_介入治疗科
作者单位1.Qingdao Univ, Coll Med, Affiliated Hosp, Dept Intervent Med, Qingdao 266003, Shandong, Peoples R China
2.Qingdao Univ, Coll Med, Affiliated Hosp, Dept Pediat, Qingdao 266003, Shandong, Peoples R China
3.Heidelberg Univ, Dept Diagnost & Intervent Radiol, D-69120 Heidelberg, Germany
4.Peking Univ, Sch Oncol, Dept Intervent Therapy, Beijing 100036, Peoples R China
推荐引用方式
GB/T 7714
Yu, Dong-Sheng,Chang, Hong,Sommer, Christof-Matthias,et al. Efficacy and safety of percutaneous microwave coagulation therapy followed by I-125 seed brachytherapy for VX2 hepatic tumors in a rabbit model[J]. EXPERIMENTAL AND THERAPEUTIC MEDICINE,2013,6(1):159-163.
APA Yu, Dong-Sheng.,Chang, Hong.,Sommer, Christof-Matthias.,Qu, Wei-Li.,Xu, Wen-Jian.,...&Zhao, Peng.(2013).Efficacy and safety of percutaneous microwave coagulation therapy followed by I-125 seed brachytherapy for VX2 hepatic tumors in a rabbit model.EXPERIMENTAL AND THERAPEUTIC MEDICINE,6(1),159-163.
MLA Yu, Dong-Sheng,et al."Efficacy and safety of percutaneous microwave coagulation therapy followed by I-125 seed brachytherapy for VX2 hepatic tumors in a rabbit model".EXPERIMENTAL AND THERAPEUTIC MEDICINE 6.1(2013):159-163.
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