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学科主题: 临床医学
题名:
Efficacy and safety of percutaneous microwave coagulation therapy followed by I-125 seed brachytherapy for VX2 hepatic tumors in a rabbit model
作者: Yu, Dong-Sheng1; Chang, Hong2; Sommer, Christof-Matthias3; Qu, Wei-Li1; Xu, Wen-Jian1; Yang, Ren-Jie4; Zhao, Peng1
关键词: liver cancer ; microwave ; I-125 seed ; computed tomography ; animal model
刊名: EXPERIMENTAL AND THERAPEUTIC MEDICINE
发表日期: 2013-07-01
DOI: 10.3892/etm.2013.1088
卷: 6, 期:1, 页:159-163
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: HEPATOCELLULAR-CARCINOMA ; RADIOFREQUENCY ABLATION ; INTERSTITIAL BRACHYTHERAPY ; THERMAL ABLATION ; LIVER-TUMORS ; LUNG-CANCER ; CHEMOEMBOLIZATION ; IMPLANTATION ; COMBINATION ; MANAGEMENT
英文摘要:

The aim of this study was to evaluate the efficacy and safety of percutaneous microwave coagulation therapy (PMCT) followed by I-125 seed brachytherapy for VX2 liver cancer in rabbits. Eighty New Zealand rabbits were injected with suspensions of VX2 tumor cells to create an animal model. The rabbits were randomly divided into 4 groups (n=20); the control, PMCT, I-125 seed brachytherapy and combination groups. Group A was treated with PMCT at 40 W for 120 sec, group B was treated with I-125 seed brachytherapy and group C was treated with PMCT followed by I-125 seed brachytherapy. Group D were not treated and served as the control group. At 21 days after treatment, the rabbits were sacrificed for pathological assessment. The complete tumor necrosis rate was 19 out of 20 tumors (95%) in group C, 6 (30%) in group A, 0 (0%) in group B and 0 (0%) in the control group. The complete tumor necrosis rate was observed to be significantly different between groups C and A, and between groups C and B (P<0.01). No intraheptic metastasis occurred in group C, compared with an incidence of 7 (35%) in group A, 2(10%) in group B and 20 (100%) in the control group. Between groups C and A, and between groups C and D, the intraheptic metastasis rate was statistically significant (P<0.01). PMCT followed by I-125 seed brachytherapy increased the rate of carcinoma necrosis and decreased carcinoma metastasis in the VX2 rabbit model. This combined treatment is a safe, effective and minimally invasive therapeutic option for liver cancer.

语种: 英语
WOS记录号: WOS:000321078900030
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55569
Appears in Collections:北京大学临床肿瘤学院_介入治疗科_期刊论文

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作者单位: 1.Qingdao Univ, Coll Med, Affiliated Hosp, Dept Intervent Med, Qingdao 266003, Shandong, Peoples R China
2.Qingdao Univ, Coll Med, Affiliated Hosp, Dept Pediat, Qingdao 266003, Shandong, Peoples R China
3.Heidelberg Univ, Dept Diagnost & Intervent Radiol, D-69120 Heidelberg, Germany
4.Peking Univ, Sch Oncol, Dept Intervent Therapy, Beijing 100036, Peoples R China

Recommended Citation:
Yu, Dong-Sheng,Chang, Hong,Sommer, Christof-Matthias,et al. Efficacy and safety of percutaneous microwave coagulation therapy followed by I-125 seed brachytherapy for VX2 hepatic tumors in a rabbit model[J]. EXPERIMENTAL AND THERAPEUTIC MEDICINE,2013,6(1):159-163.
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