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学科主题临床医学
In Situ Malignant Transformation and Progenitor-Mediated Cell Budding: Two Different Pathways for Breast Ductal and Lobular Tumor Invasion
Man, Yan-gao1,2; Izadjoo, Mina1,2; Song, Guohong3; Stojadinovic, Alexander4
关键词Breast Cancer Tumor Invasion Tumor Metastasis Malignant Transformation Tumor Cell Budding Myoepithelial Cells Tumor Microenvironment Tumor Stem Cells Lymphocytes
刊名JOURNAL OF CANCER
2011
DOI10.7150/jca.2.401
2页:401-412
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
英文摘要

The human breast lobular and ductal structures and the derived tumors from these structures differ substantial in their morphology, microenvironment, biological presentation, functions, and clinical prognosis. Based on these differences, we have proposed that pre-invasive lobular tumors may progress to invasive lesions through "in situ malignant transformation", in which the entire myoepithelial cell layer within a given lobule or lobular clusters undergoes extensive degeneration and disruptions, which allows the entire epithelial cell population associated with these myoepithelial cell layers directly invade the stroma or vascular structures. In contrast, pre-invasive ductal tumors may invade the stroma or vascular structures through "progenitor-mediated cell budding", in which focal myoepithelial cell degeneration-induced aberrant leukocyte infiltration causes focal disruptions in the tumor capsules, which selectively favor monoclonal proliferation of the overlying tumor stem cells or a biologically more aggressive cell clone. Our current study attempted to provide more direct morphological and immunohistochemical data that are consistent with our hypotheses.

语种英语
WOS记录号WOS:000208695300052
项目编号DAMD17-01-1-0129 ; DAMD17-01-1-0130 ; PC051308 ; BCTR0706983 ; 05AA ; 2008-02 ; 2008-02 ; 2006CB910505
资助机构Congressionally Directed Medical Research Programs ; Susan G. Komen Breast Cancer Foundation ; AFIP/ARP joint research initiative projects ; US Military Cancer Institute ; Henry M. Jackson Foundation ; Ministry of Chinese Science and Technology Department
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55570
专题北京大学临床肿瘤学院_肿瘤内科
北京大学临床肿瘤学院_乳腺肿瘤内科
作者单位1.Armed Forces Inst Pathol, Washington, DC 20306 USA
2.Armed Forces Inst Pathol, Dept Infect & Parasit Dis Pathol, Amer Registry Pathol, Washington, DC 20306 USA
3.Peking Univ, Canc Hosp & Inst, Dept Med Oncol, Beijing, Peoples R China
4.Walter Reed Army Med Ctr, Washington, DC 20307 USA
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Man, Yan-gao,Izadjoo, Mina,Song, Guohong,et al. In Situ Malignant Transformation and Progenitor-Mediated Cell Budding: Two Different Pathways for Breast Ductal and Lobular Tumor Invasion[J]. JOURNAL OF CANCER,2011,2:401-412.
APA Man, Yan-gao,Izadjoo, Mina,Song, Guohong,&Stojadinovic, Alexander.(2011).In Situ Malignant Transformation and Progenitor-Mediated Cell Budding: Two Different Pathways for Breast Ductal and Lobular Tumor Invasion.JOURNAL OF CANCER,2,401-412.
MLA Man, Yan-gao,et al."In Situ Malignant Transformation and Progenitor-Mediated Cell Budding: Two Different Pathways for Breast Ductal and Lobular Tumor Invasion".JOURNAL OF CANCER 2(2011):401-412.
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