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学科主题: 基础医学
题名:
Treatment with Cardiotonic Pills (R) after Ischemia-Reperfusion Ameliorates Myocardial Fibrosis in Rats
作者: Wei, Xiao-Hong1,2; Liu, Yu-Ying1,2; Li, Quan1,2; Yan, Li1,2; Hu, Bai-He1,2; Pan, Chun-Shui1,2; Li, Zhi-Xin1,2; Chang, Xin1,2; Fan, Jing-Yu1,2; Zhao, Na1,2; Sun, Kai1,2; Huang, Ping1,2; Wang, Chuan-She1,2; Fan, Tai-Ping3; Han, Jing-Yan1,2,4
关键词: chemokines ; cardiac microcirculation ; myocardial infarction ; leukocytes
刊名: MICROCIRCULATION
发表日期: 2013
DOI: 10.1111/micc.12002
卷: 20, 期:1, 页:17-29
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Peripheral Vascular Disease
研究领域[WOS]: Hematology ; Cardiovascular System & Cardiology
关键词[WOS]: S19 RIBOSOMAL-PROTEIN ; SALVIANOLIC-ACID-B ; INDUCED MICROCIRCULATORY DISTURBANCE ; MONOCYTE CHEMOTACTIC FACTOR ; HEPATIC STELLATE CELLS ; TGF-BETA ; CARDIAC FIBROBLASTS ; FIBROTIC RESPONSE ; PANAX-NOTOGINSENG ; CHINESE MEDICINE
英文摘要:

Objective The present study was designed to evaluate whether CP was beneficial in alleviating myocardial fibrosis following I/R injury. Methods SpragueDawley rats were subjected to 30 minutes occlusion of the LADCA, followed by reperfusion. CP (0.4 or 0.8 g/kg) was daily administered starting from three hour after reperfusion until day 6. Coronary venular diameter, RBC velocity, albumin leakage, MBF, heart function, myocardial infarction and fibrosis size, myocardium ultrastructure, MPO activity, and MDA level were evaluated. The expression of MCP-1, RP S19, TGF-beta 1, P-Smad3, Smad4, MMP-9 and a-SMA, and the infiltration of leukocytes were examined. Results CP post-treatment ameliorated I/R-induced myocardial RBC velocity reduction, MBF decrease, cardiac dysfunction, and albumin leakage increase. Moreover, myocardial infarction and fibrosis size, MPO activity, MDA level, the expression of RP S19, TGF-beta 1, P-Smad3, Smad4, MMP-9 and a-SMA, the number of CD68-positive cells increased significantly after I/R, and myocardium collagen deposition was observed on day 6 after reperfusion. All the alterations after I/R were significantly ameliorated by CP. Conclusions Post-treatment with CP ameliorates I/R-induced myocardial fibrosis, suggesting that CP may be applied as an option for preventing cardiac remodeling after I/R injury.

语种: 英语
所属项目编号: 2008ZX09401
项目资助者: Production of New Medicine Program of Ministry of the Science and Technology of the People&prime ; s Republic of China
WOS记录号: WOS:000313595900002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55573
Appears in Collections:基础医学院_北大医学部天士力微循环研究中心_期刊论文

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作者单位: 1.Peking Univ, Tasly Microcirculat Res Ctr, Hlth Sci Ctr, Beijing 100191, Peoples R China
2.State Adm Tradit Chinese Med, Key Lab Microcirculat, Beijing, Peoples R China
3.Univ Cambridge, Dept Pharmacol, Trinity Coll, Cambridge CB2 1QJ, England
4.Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100191, Peoples R China

Recommended Citation:
Wei, Xiao-Hong,Liu, Yu-Ying,Li, Quan,et al. Treatment with Cardiotonic Pills (R) after Ischemia-Reperfusion Ameliorates Myocardial Fibrosis in Rats[J]. MICROCIRCULATION,2013,20(1):17-29.
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