学科主题基础医学
Conjugate of bovine hemoglobin and human serum albumin as a candidate for blood substitute: Characteristics and effects on rats
Lu, XL; Zheng, CY; Shi, XD; Wang, YQ; Suo, XY; Yu, PZ; Xu, YH; Ma, TM; Su, ZG
关键词Bovine Hemoglobin Human Serum Albumin Conjugate Blood Substitutes Glutaraldehyde
刊名ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY
2005
DOI10.1081/BIO-200055841
33期:2页:83-99
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]Biotechnology & Applied Microbiology ; Engineering ; Materials Science
关键词[WOS]CROSS-LINKED HEMOGLOBIN ; SAFETY
英文摘要

Conjugate of bovine hemoglobin (bHb) and human serum albumin (HSA) was prepared. The product was simply composed of 89.7% one-to-one Hb-HSA conjugate, 6.0% oligomer of Hb and HSA, 3.5% unconjugated HSA and 0.8% unconjugated Hb, with an average molecular weight of 157kD. The physicochemical characteristics were determined. Effects of single replacement on blood pressure and long-term survival of rats with 30% and 60% acute blood loss were studied, in comparison with Ringer-lactate solution, stroma-free hemoglobin (SFHb), 5% HSA in Ringer-lactate, whole blood and no resuscitation fluid. Results showed that Hb-HSA conjugate maintained the mean arterial pressure of rats to initial level with no pressor effect. Long-term effects of the replacement fluids on 30% bleeding rats showed that, for the group infused with Hb-HSA conjugate, histology of five major organs, heart, kidney, liver, spleen and lung, were essentially normal, similar to that of whole blood, while obviously renal side-effects appeared in other groups. The efficacy of the conjugate was further demonstrated by the resuscitation of lethal hemorrhagic shock rats (60% acute blood loss) with 100% survival rate (followed for 14 days), the same result as whole blood. The Hb-HSA conjugate can thus be another candidate for blood substitute in emergency.

语种英语
WOS记录号WOS:000230198300001
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55576
专题北京大学基础医学院_生理学与病理生理学系
作者单位1.Chinese Acad Sci, Natl Key Lab Biochem Engn, Inst Proc Engn, Beijing 100080, Peoples R China
2.Univ Sci & Technol, Dept Environm Engn, Beijing, Peoples R China
3.Beijing Univ Chem Technol, Dept Bioengn, Beijing, Peoples R China
4.Peking Univ, Sch Basic Med Sci, Dept Physiol, Beijing 100871, Peoples R China
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GB/T 7714
Lu, XL,Zheng, CY,Shi, XD,et al. Conjugate of bovine hemoglobin and human serum albumin as a candidate for blood substitute: Characteristics and effects on rats[J]. ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY,2005,33(2):83-99.
APA Lu, XL.,Zheng, CY.,Shi, XD.,Wang, YQ.,Suo, XY.,...&Su, ZG.(2005).Conjugate of bovine hemoglobin and human serum albumin as a candidate for blood substitute: Characteristics and effects on rats.ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY,33(2),83-99.
MLA Lu, XL,et al."Conjugate of bovine hemoglobin and human serum albumin as a candidate for blood substitute: Characteristics and effects on rats".ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY 33.2(2005):83-99.
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