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学科主题: 基础医学
题名:
Comparison of immunogenicity between inactivated and live attenuated hepatitis A vaccines A single-blind, randomized, parallel-group clinical trial among children in Xinjiang Uighur Autonomous Region, China
作者: Liu, Xue-en1,2; Wushouer, Fuerhati3; Gou, Aili3; Kuerban, Mahemuti3; Li, Xinlan3; Sun, Yubo4; Zhang, Jiamin4; Liu, Yan5; Li, Jie1,2; Zhuang, Hui1,2
关键词: inactivated hepatitis A vaccine ; live attenuated hepatitis A vaccine ; immunogenicity
刊名: HUMAN VACCINES & IMMUNOTHERAPEUTICS
发表日期: 2013-07-01
DOI: 10.4161/hv.24366
卷: 9, 期:7, 页:1460-1465
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Immunology
研究领域[WOS]: Biotechnology & Applied Microbiology ; Immunology
关键词[WOS]: UNITED-STATES ; VACCINATION ; IMMUNIZATION
英文摘要:

Objectives: To compare immunogenicity among an inactivated hepatitis A vaccine (Healive (R)) with one-dose and two-dose regimens, and three kinds of live attenuated vaccines in children. Results: No significant differences were observed in seroconversion rates (seroprotection rates) among the five groups at 6 or 12 mo (p > 0.05). The geometric mean concentration (GMC) of anti-HAV IgG was significantly higher in the two-dose Healive (R) group than in the one-dose Healive (R) group and the attenuated vaccine groups at 12 mo (932.4 vs. 112.7, 135.8, 203.3, 212.8 mIU/ml, respectively, p < 0.05). In the one-dose Healive (R) group, the GMC was significantly lower than that in the attenuated vaccine B and C groups at 6 mo (152.6 vs. 212, 204 mIU/ml, p < 0.05) and at 12 mo (112.7 vs. 203.3, 212.8, p < 0.05), but was similar to the attenuated vaccine A group at 12 mo (112.7 vs. 135.8 mIU/ml, p > 0.05). The GMCs were significantly higher in the 1-2 y of age group than in the 3-6 y of age group for all types of vaccines except the attenuated vaccine C (p < 0.05) at 12 mo. Methods: A single-blind, randomized, parallel-group clinical trial was conducted among healthy children aged 1.5-6 y in Xinjiang Uighur Autonomous Region, China. Subjects were randomly assigned to 5 groups. Two groups were administered one-dose or two-dose inactivated vaccine and the remaining groups were immunized with one of three kinds of attenuated vaccines, respectively. Serum samples were collected at 6- and 12-mo follow-ups. Anti-HAV IgG was measured with a microparticle enzyme immunoassay. Conclusions: A higher GMC of anti-HAV IgG was induced in the two-dose Healive (R) than in the one-dose and the attenuated vaccines at 12 mo. The attenuated vaccine B or C produced higher GMCs than the one-dose Healive (R) at 6-12 mo after vaccination.

语种: 英语
项目资助者: Sinovac Biotech Co., Ltd (Beijing, China)
WOS记录号: WOS:000328572700020
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55589
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Sinovac Biotech Co Ltd, Beijing, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100871, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Basic Med, Ctr Infect Dis, Beijing 100871, Peoples R China
4.Xinjiang Uighur Autonomous Reg Ctr Dis Control &, Urumqi, Xinjiang, Peoples R China
5.Changji City Ctr Dis Control & Prevent, Changji, Xinjiang, Peoples R China

Recommended Citation:
Liu, Xue-en,Wushouer, Fuerhati,Gou, Aili,et al. Comparison of immunogenicity between inactivated and live attenuated hepatitis A vaccines A single-blind, randomized, parallel-group clinical trial among children in Xinjiang Uighur Autonomous Region, China[J]. HUMAN VACCINES & IMMUNOTHERAPEUTICS,2013,9(7):1460-1465.
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