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学科主题基础医学
Comparison of immunogenicity between inactivated and live attenuated hepatitis A vaccines A single-blind, randomized, parallel-group clinical trial among children in Xinjiang Uighur Autonomous Region, China
Liu, Xue-en1,2; Wushouer, Fuerhati3; Gou, Aili3; Kuerban, Mahemuti3; Li, Xinlan3; Sun, Yubo4; Zhang, Jiamin4; Liu, Yan5; Li, Jie1,2; Zhuang, Hui1,2
关键词inactivated hepatitis A vaccine live attenuated hepatitis A vaccine immunogenicity
刊名HUMAN VACCINES & IMMUNOTHERAPEUTICS
2013-07-01
DOI10.4161/hv.24366
9期:7页:1460-1465
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Immunology
资助者Sinovac Biotech Co., Ltd (Beijing, China) ; Sinovac Biotech Co., Ltd (Beijing, China)
研究领域[WOS]Biotechnology & Applied Microbiology ; Immunology
关键词[WOS]UNITED-STATES ; VACCINATION ; IMMUNIZATION
英文摘要

Objectives: To compare immunogenicity among an inactivated hepatitis A vaccine (Healive (R)) with one-dose and two-dose regimens, and three kinds of live attenuated vaccines in children. Results: No significant differences were observed in seroconversion rates (seroprotection rates) among the five groups at 6 or 12 mo (p > 0.05). The geometric mean concentration (GMC) of anti-HAV IgG was significantly higher in the two-dose Healive (R) group than in the one-dose Healive (R) group and the attenuated vaccine groups at 12 mo (932.4 vs. 112.7, 135.8, 203.3, 212.8 mIU/ml, respectively, p < 0.05). In the one-dose Healive (R) group, the GMC was significantly lower than that in the attenuated vaccine B and C groups at 6 mo (152.6 vs. 212, 204 mIU/ml, p < 0.05) and at 12 mo (112.7 vs. 203.3, 212.8, p < 0.05), but was similar to the attenuated vaccine A group at 12 mo (112.7 vs. 135.8 mIU/ml, p > 0.05). The GMCs were significantly higher in the 1-2 y of age group than in the 3-6 y of age group for all types of vaccines except the attenuated vaccine C (p < 0.05) at 12 mo. Methods: A single-blind, randomized, parallel-group clinical trial was conducted among healthy children aged 1.5-6 y in Xinjiang Uighur Autonomous Region, China. Subjects were randomly assigned to 5 groups. Two groups were administered one-dose or two-dose inactivated vaccine and the remaining groups were immunized with one of three kinds of attenuated vaccines, respectively. Serum samples were collected at 6- and 12-mo follow-ups. Anti-HAV IgG was measured with a microparticle enzyme immunoassay. Conclusions: A higher GMC of anti-HAV IgG was induced in the two-dose Healive (R) than in the one-dose and the attenuated vaccines at 12 mo. The attenuated vaccine B or C produced higher GMCs than the one-dose Healive (R) at 6-12 mo after vaccination.

语种英语
资助者Sinovac Biotech Co., Ltd (Beijing, China) ; Sinovac Biotech Co., Ltd (Beijing, China)
WOS记录号WOS:000328572700020
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55589
专题基础医学院_病原生物学系
作者单位1.Sinovac Biotech Co Ltd, Beijing, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100871, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Basic Med, Ctr Infect Dis, Beijing 100871, Peoples R China
4.Xinjiang Uighur Autonomous Reg Ctr Dis Control &, Urumqi, Xinjiang, Peoples R China
5.Changji City Ctr Dis Control & Prevent, Changji, Xinjiang, Peoples R China
推荐引用方式
GB/T 7714
Liu, Xue-en,Wushouer, Fuerhati,Gou, Aili,et al. Comparison of immunogenicity between inactivated and live attenuated hepatitis A vaccines A single-blind, randomized, parallel-group clinical trial among children in Xinjiang Uighur Autonomous Region, China[J]. HUMAN VACCINES & IMMUNOTHERAPEUTICS,2013,9(7):1460-1465.
APA Liu, Xue-en.,Wushouer, Fuerhati.,Gou, Aili.,Kuerban, Mahemuti.,Li, Xinlan.,...&Zhuang, Hui.(2013).Comparison of immunogenicity between inactivated and live attenuated hepatitis A vaccines A single-blind, randomized, parallel-group clinical trial among children in Xinjiang Uighur Autonomous Region, China.HUMAN VACCINES & IMMUNOTHERAPEUTICS,9(7),1460-1465.
MLA Liu, Xue-en,et al."Comparison of immunogenicity between inactivated and live attenuated hepatitis A vaccines A single-blind, randomized, parallel-group clinical trial among children in Xinjiang Uighur Autonomous Region, China".HUMAN VACCINES & IMMUNOTHERAPEUTICS 9.7(2013):1460-1465.
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