IR@PKUHSC  > 北京大学第一临床医学院  > 心血管内科
学科主题临床医学
Effects of exogenous urotensin II on vascular remodelling after balloon injury
Zhang, Li-Fang1,2; Ding, Wen-Hui1; Shi, Li-Bin1; Li, Kang1; Haom, Yan-Jie1; Ke, Yuan-Nan2; Tang, Zhao-Shu3
关键词Arteries Balloon Angioplasty Extracellular Matrix Restenosis Urotensin Ii Vascular Remodelling
刊名CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
2010-04-01
DOI10.1111/j.1440-1681.2009.05336.x
37期:4页:477-481
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Physiology
研究领域[WOS]Pharmacology & Pharmacy ; Physiology
关键词[WOS]RECEPTOR GPR14 ; RAT ; RESTENOSIS ; IMMUNOREACTIVITY ; PROLIFERATION ; HYPERTENSION ; ANGIOPLASTY ; EXPRESSION ; DISEASE ; CELLS
英文摘要

P>1. Urotensin II (U-II) is a powerful vasoconstrictor peptide that stimulates cell proliferation. However, the systemic effects of U-II on cellular and extracellular matrix responses of vessel walls have not been investigated. The aim of the present study was to determine the effect of exogenous U-II on arterial neointimal hyperplasia after balloon injury.

2. A stenosis model of the thoracic aorta after balloon injury was established in male Wistar rats. Rats were divided into three groups (n = 5 in each): (i) uninjured; (ii) injured for 21 days; and (iii) injured and then treated with U-II (1 nmol/kg per h) via an osmotic minipump for 21 days. Another group of rats were killed on Days 7 and 14 after balloon injury for the analysis of in vitro collagen synthesis and secretion with U-II treated by [3H]-proline incorporation and determination of [3H]-hydroxyproline radioactivity, respectively.

3. Urotensin II immunoreactivity was 1.74-fold higher in vessels injured for 21 days than in uninjured vessels and mRNA levels of the urotensin UT receptor were upregulated by 55% following injury. After U-II treatment, the mRNA levels of the UT receptor were further upregulated (by 40%). In addition, U-II treatment increased the intimal area of injured aortas (13 +/- 5 vs 7 +/- 2% in group iii and ii, respectively), as well as increasing collagen content and cell proliferation. Protein levels of matrix metalloproteinase 1 were decreased in U-II-treated rats. In vitro, U-II treatment increased collagen synthesis and secretion in uninjured vessels in a concentration-dependent manner (10-10, 10-9 and 10-8 mol/L U-II), especially in injured aortas on Day 7 after injury.

4. In conclusion, exogenous U-II may upregulate mRNA levels of the UT receptor, as well as increase collagen and cell proliferation, all of which would contribute to intimal hyperplasia after angioplasty.

语种英语
WOS记录号WOS:000275766900014
项目编号30270541 ; 30871066
资助机构National Natural Science Foundation of China
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55590
专题北京大学第一临床医学院_心血管内科
作者单位1.Peking Univ, Hosp 1, Div Cardiol, Dept Internal Med, Beijing 100034, Peoples R China
2.China Japan Friendship Hosp, Dept Internal Med, Div Cardiol, Beijing, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Minist Educ, Dept Physiol & Pathophysiol,Key Lab Mol Cardiol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Li-Fang,Ding, Wen-Hui,Shi, Li-Bin,et al. Effects of exogenous urotensin II on vascular remodelling after balloon injury[J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,2010,37(4):477-481.
APA Zhang, Li-Fang.,Ding, Wen-Hui.,Shi, Li-Bin.,Li, Kang.,Haom, Yan-Jie.,...&Tang, Zhao-Shu.(2010).Effects of exogenous urotensin II on vascular remodelling after balloon injury.CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,37(4),477-481.
MLA Zhang, Li-Fang,et al."Effects of exogenous urotensin II on vascular remodelling after balloon injury".CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 37.4(2010):477-481.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Li-Fang]的文章
[Ding, Wen-Hui]的文章
[Shi, Li-Bin]的文章
百度学术
百度学术中相似的文章
[Zhang, Li-Fang]的文章
[Ding, Wen-Hui]的文章
[Shi, Li-Bin]的文章
必应学术
必应学术中相似的文章
[Zhang, Li-Fang]的文章
[Ding, Wen-Hui]的文章
[Shi, Li-Bin]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。