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学科主题: 临床医学
题名:
Potassium channel activator attenuates salicylate-induced cochlear hearing loss potentially ameliorating tinnitus
作者: Sun, Wei1; Liu, Jun2; Zhang, Chao2; Zhou, Na3; Manohar, Senthilvelan1; Winchester, Wendy4; Miranda, Jason A.4; Salvi, Richard J.1
关键词: salicylate ; KCNQ ; hearing loss ; compound action potential ; otoacoustic emission
刊名: FRONTIERS IN NEUROLOGY
发表日期: 2015-04-07
DOI: 10.3389/fneur.2015.00077
卷: 6
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: OUTER HAIR-CELLS ; GUINEA-PIG COCHLEA ; DOMINANT DEAFNESS ; INNER-EAR ; KCNQ4 ; EXPRESSION ; BRAIN ; RAT ; RESPONSES ; SUBUNITS
英文摘要:

High dose sodium salicylate causes moderate, reversible hearing loss and tinnitus. Salicylate-induced hearing loss is believed to arise from a reduction in the electromotile response of outer hair cells (OHCs) and/or reduction of KCNQ4 potassium currents in OHCs, which decreases the driving force for the transduction current. Therefore, enhancing OHC potassium currents could potentially prevent salicylate-induced temporary hearing loss. In this study, we tested whether opening voltage-gated potassium channels using ICA-105665, a novel small molecule that opens KCNQ2/3 and KCNQ3/5 channels, can reduce salicylate-induced hearing loss. We found that systemic application of ICA-105665 at 10 mg/kg prevented the salicylate-induced amplitude reduction and threshold shift in the compound action potentials recorded at the round window of the cochlea. ICA-105665 also prevented the salicylate-induced reduction of distortion-product otoacoustic emission. These results suggest that ICA-105665 partially compensates for salicylate-induced cochlear hearing loss by enhancing KCNQ2/3 and KCNQ3/5 potassium currents and the motility of OHCs.

语种: 英语
WOS记录号: WOS:000363776300001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55600
Appears in Collections:北京大学第三临床医学院_耳鼻喉科_期刊论文

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作者单位: 1.Pfizer, Neusentis Res Unit, Cambridge, England
2.SUNY Buffalo, Ctr Hearing & Deafness, Buffalo, NY 14214 USA
3.Gen Hosp PLA, Dept Otolaryngol, Beijing, Peoples R China
4.Peking Univ, Hosp 3, Dept Otolaryngol, Beijing 100871, Peoples R China

Recommended Citation:
Sun, Wei,Liu, Jun,Zhang, Chao,et al. Potassium channel activator attenuates salicylate-induced cochlear hearing loss potentially ameliorating tinnitus[J]. FRONTIERS IN NEUROLOGY,2015,6.
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