北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 耳鼻喉科  > 期刊论文
学科主题: 临床医学
题名:
Potassium channel activator attenuates salicylate-induced cochlear hearing loss potentially ameliorating tinnitus
作者: Sun, Wei1; Liu, Jun2; Zhang, Chao2; Zhou, Na3; Manohar, Senthilvelan1; Winchester, Wendy4; Miranda, Jason A.4; Salvi, Richard J.1
关键词: salicylate ; KCNQ ; hearing loss ; compound action potential ; otoacoustic emission
刊名: FRONTIERS IN NEUROLOGY
发表日期: 2015-04-07
DOI: 10.3389/fneur.2015.00077
卷: 6
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: OUTER HAIR-CELLS ; GUINEA-PIG COCHLEA ; DOMINANT DEAFNESS ; INNER-EAR ; KCNQ4 ; EXPRESSION ; BRAIN ; RAT ; RESPONSES ; SUBUNITS
英文摘要:

High dose sodium salicylate causes moderate, reversible hearing loss and tinnitus. Salicylate-induced hearing loss is believed to arise from a reduction in the electromotile response of outer hair cells (OHCs) and/or reduction of KCNQ4 potassium currents in OHCs, which decreases the driving force for the transduction current. Therefore, enhancing OHC potassium currents could potentially prevent salicylate-induced temporary hearing loss. In this study, we tested whether opening voltage-gated potassium channels using ICA-105665, a novel small molecule that opens KCNQ2/3 and KCNQ3/5 channels, can reduce salicylate-induced hearing loss. We found that systemic application of ICA-105665 at 10 mg/kg prevented the salicylate-induced amplitude reduction and threshold shift in the compound action potentials recorded at the round window of the cochlea. ICA-105665 also prevented the salicylate-induced reduction of distortion-product otoacoustic emission. These results suggest that ICA-105665 partially compensates for salicylate-induced cochlear hearing loss by enhancing KCNQ2/3 and KCNQ3/5 potassium currents and the motility of OHCs.

语种: 英语
WOS记录号: WOS:000363776300001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55600
Appears in Collections:北京大学第三临床医学院_耳鼻喉科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Pfizer, Neusentis Res Unit, Cambridge, England
2.SUNY Buffalo, Ctr Hearing & Deafness, Buffalo, NY 14214 USA
3.Gen Hosp PLA, Dept Otolaryngol, Beijing, Peoples R China
4.Peking Univ, Hosp 3, Dept Otolaryngol, Beijing 100871, Peoples R China

Recommended Citation:
Sun, Wei,Liu, Jun,Zhang, Chao,et al. Potassium channel activator attenuates salicylate-induced cochlear hearing loss potentially ameliorating tinnitus[J]. FRONTIERS IN NEUROLOGY,2015,6.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Sun, Wei]'s Articles
[Liu, Jun]'s Articles
[Zhang, Chao]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Sun, Wei]‘s Articles
[Liu, Jun]‘s Articles
[Zhang, Chao]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace