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学科主题: 基础医学
题名:
Systematic administration of B vitamins attenuates neuropathic hyperalgesia and reduces spinal neuron injury following temporary spinal cord ischaemia in rats
作者: Yu, C. -Z.1; Liu, Y. -P.1,4; Liu, S.4; Yan, M.1; Hu, S. -J.1; Song, X. -J.2,3,4
刊名: EUROPEAN JOURNAL OF PAIN
发表日期: 2014
DOI: 10.1002/j.1532-2149.2013.00390.x
卷: 18, 期:1, 页:76-85
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Anesthesiology ; Clinical Neurology ; Neurosciences
研究领域[WOS]: Anesthesiology ; Neurosciences & Neurology
关键词[WOS]: DORSAL-HORN ; GABA-IMMUNOREACTIVITY ; AORTIC OCCLUSION ; GABAERGIC TONE ; PAIN ; THIAMINE ; ACID ; CYANOCOBALAMIN ; MICE ; NEUROTRANSMISSION
英文摘要:

BackgroundB vitamins have been demonstrated to be effective in treating chronic pain due to peripheral nerve injury. We investigated whether B vitamins could alleviate neuropathic pain and reduce neuron injury following temporary ischaemia in a rat model of spinal cord ischaemia-reperfusion injury (SCII).

MethodsSCII was produced by transiently blocking the unilateral lumbar arteries in adult male Sprague-Dawley rats. Behavioural and neurochemical signs of neuropathic pain and spinal neuron injury were analysed with and without B vitamin treatment.

ResultsSCII caused behavioural thermal hyperalgesia and mechanical allodynia and neurochemical alterations, including increased expression of the vanilloid receptor 1 (VR1) and induction of c-Fos, as well as activation of the astrocytes and microglial cells in the spinal cord. Repetitive systemic administration of vitamin B complex (B1/B6/B12 at 33/33/0.5mg/kg, i.p., daily, for 7-14 consecutive days) significantly reduced thermal hyperalgesia and the increased expression of VR1 and c-Fos, as well as activation of the astrocytes and microglial cells. SCII caused a dramatic decrease of the expression of the rate-limiting enzyme glutamic acid decarboxylase-65 (GAD65), which synthesizes -aminobutyric acid (GABA) in the axonal terminals, and -III-tubulin, and also caused loss of Nissl bodies in the spinal cord. These alterations were largely prevented and rescued by the B vitamin treatment.

ConclusionsThese findings support the idea that the B vitamins are capable of neuroprotection and antinociception during spinal cord injury due to temporary ischaemia. Rescuing the loss of inhibitory GABAergic tone may reduce spinal central sensitization and contribute to B vitamin-induced analgesia.

语种: 英语
所属项目编号: NSFC-81271241 ; NSCF-81320108012 ; NSFC-81000475 ; BMU20120310 ; PRF-BSR11120607
项目资助者: National Natural Science Foundation of China ; Peking University ; Parker Research Foundation
WOS记录号: WOS:000327895100009
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55602
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Fourth Mil Med Univ, Inst Neurosci, Xian 710032, Peoples R China
2.Peking Univ, Neurosci Res Inst, Beijing 100871, Peoples R China
3.Peking Univ, Ctr Pain Med, Beijing 100871, Peoples R China
4.Parker Univ, Dept Neurobiol, Dallas, TX USA

Recommended Citation:
Yu, C. -Z.,Liu, Y. -P.,Liu, S.,et al. Systematic administration of B vitamins attenuates neuropathic hyperalgesia and reduces spinal neuron injury following temporary spinal cord ischaemia in rats[J]. EUROPEAN JOURNAL OF PAIN,2014,18(1):76-85.
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