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Chemoselective reduction and self-immolation based FRET probes for detecting hydrogen sulfide in solution and in cells
Chen, Bifeng1; Wang, Peng1; Jin, Qingqing1; Tang, Xinjing1,2
刊名ORGANIC & BIOMOLECULAR CHEMISTRY
2014-08-14
DOI10.1039/c4ob00923a
12期:30页:5629-5633
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]RATIOMETRIC FLUORESCENT-PROBE ; LIVING CELLS ; H2S ; RECOGNITION ; ANGIOGENESIS ; RELEASE ; TISSUES ; SENSOR ; BRAIN ; ANION
英文摘要

Hydrogen sulfide (H2S) has been regarded as the third gaseous transmitter. Based on the mechanism of chemoselective azido reduction and self-immolation, five fluorescence resonance energy transfer (FRET) probes for the detection of H2S were designed and synthesized. The effect of functional substitution of the self-immolative moiety on azido reduction and quinone-methide rearrangement were investigated. Their fluorescence responses and chemoselectivity for H2S detection were evaluated in solutions and in cells. This strategy may provide a general route for designing H2S probes with many commercially available FRET pairs.

语种英语
WOS记录号WOS:000339138300013
项目编号2013CB933800 ; 2012CB720600 ; 21372018 ; KF-GN-201305
资助机构National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; State Key Laboratory of Pharmaceutical Biotechnology
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55603
专题北京大学药学院
北京大学医学部管理机构_医学部
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Nanjing, Peoples R China
推荐引用方式
GB/T 7714
Chen, Bifeng,Wang, Peng,Jin, Qingqing,et al. Chemoselective reduction and self-immolation based FRET probes for detecting hydrogen sulfide in solution and in cells[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2014,12(30):5629-5633.
APA Chen, Bifeng,Wang, Peng,Jin, Qingqing,&Tang, Xinjing.(2014).Chemoselective reduction and self-immolation based FRET probes for detecting hydrogen sulfide in solution and in cells.ORGANIC & BIOMOLECULAR CHEMISTRY,12(30),5629-5633.
MLA Chen, Bifeng,et al."Chemoselective reduction and self-immolation based FRET probes for detecting hydrogen sulfide in solution and in cells".ORGANIC & BIOMOLECULAR CHEMISTRY 12.30(2014):5629-5633.
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