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学科主题: 药学
题名:
Chemoselective reduction and self-immolation based FRET probes for detecting hydrogen sulfide in solution and in cells
作者: Chen, Bifeng1; Wang, Peng1; Jin, Qingqing1; Tang, Xinjing1,2
刊名: ORGANIC & BIOMOLECULAR CHEMISTRY
发表日期: 2014-08-14
DOI: 10.1039/c4ob00923a
卷: 12, 期:30, 页:5629-5633
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: RATIOMETRIC FLUORESCENT-PROBE ; LIVING CELLS ; H2S ; RECOGNITION ; ANGIOGENESIS ; RELEASE ; TISSUES ; SENSOR ; BRAIN ; ANION
英文摘要:

Hydrogen sulfide (H2S) has been regarded as the third gaseous transmitter. Based on the mechanism of chemoselective azido reduction and self-immolation, five fluorescence resonance energy transfer (FRET) probes for the detection of H2S were designed and synthesized. The effect of functional substitution of the self-immolative moiety on azido reduction and quinone-methide rearrangement were investigated. Their fluorescence responses and chemoselectivity for H2S detection were evaluated in solutions and in cells. This strategy may provide a general route for designing H2S probes with many commercially available FRET pairs.

语种: 英语
所属项目编号: 2013CB933800 ; 2012CB720600 ; 21372018 ; KF-GN-201305
项目资助者: National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; State Key Laboratory of Pharmaceutical Biotechnology
WOS记录号: WOS:000339138300013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55603
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Nanjing, Peoples R China

Recommended Citation:
Chen, Bifeng,Wang, Peng,Jin, Qingqing,et al. Chemoselective reduction and self-immolation based FRET probes for detecting hydrogen sulfide in solution and in cells[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2014,12(30):5629-5633.
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