北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 中国药物依赖性研究所  > 期刊论文
学科主题: 药物依赖
题名:
Replication of Association between Schizophrenia and Chromosome 6p21-6p22.1 Polymorphisms in Chinese Han Population
作者: Zhang, Yang1,2,3; Lu, Tianlan2,3; Yan, Hao2,3; Ruan, Yanyan2,3; Wang, Lifang2,3; Zhang, Dai2,3; Yue, Weihua2,3; Lu, Lin1
刊名: PLOS ONE
发表日期: 2013-02-21
DOI: 10.1371/journal.pone.0056732
卷: 8, 期:2
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: GENOME-WIDE ASSOCIATION ; SUSCEPTIBILITY GENE ; JAPANESE PATIENTS ; LINKAGE ANALYSES ; COMMON VARIANTS ; SCAN DOMAIN ; LOCUS ; 6P ; RISK ; HLA
英文摘要:

Chromosome 6p21-p22.1, spanning the extended major histocompatibility complex (MHC) region, is a highly polymorphic, gene-dense region. It has been identified as a susceptibility locus of schizophrenia in Europeans, Japanese, and Chinese. In our previous two-stage genome-wide association study (GWAS), polymorphisms of zinc finger with KRAB and SCAN domains 4 (ZKSCAN4), nuclear factor-kappa B-activating protein-like (NKAPL), and piggyBac transposable element derived 1 (PGBD1), localized to chromosome 6p21-p22.1, were strongly associated with schizophrenia. To further investigate the association between polymorphisms at this locus and schizophrenia in the Chinese Han population, we selected eight other single-nucleotide polymorphisms (SNPs) distributed in or near these genes for a case-control association study in an independent sample of 902 cases and 1,091 healthy controls in an attempt to replicate the GWAS results. Four of these eight SNPs (rs12214383, rs1150724, rs3800324, and rs1997660) displayed a nominal difference in allele frequencies between the case and control groups. The association between two of these SNPs and schizophrenia were significant even after Bonferroni correction (rs12000: allele A. G, P = 2.50E-04, odds ratio [OR] = 1.27, 95% confidence interval [CI] = 1.12-1.45; rs1150722: allele C. T, P = 4.28E-05, OR = 0.55, 95% CI = 0.41-0.73). Haplotype ATTGACGC, comprising these eight SNPs (rs2235359, rs2185955, rs12214383, rs12000, rs1150724, rs1150722, rs3800324, and rs1997660), was significantly associated with schizophrenia (P = 6.60E-05). We also performed a combined study of this replication sample and the first-stage GWAS sample. The combined study revealed that rs12000 and rs1150722 were still strongly associated with schizophrenia (rs12000: allele G. A, P-combined = 0.0019, OR = 0.81; rs1150722: allele G. A, P-combined = 3.00E-04, OR = 0.61). These results support our findings that locus 6p21-p22.1 is significantly associated with schizophrenia in the Chinese Han population and encourage further studies of the functions of these genetic factors.

语种: 英语
所属项目编号: 81071087 ; 81071088 ; 2010DFB30820
项目资助者: National Natural Science Foundation of China ; International Science &amp ; Technology Cooperation Program of China
WOS记录号: WOS:000315186000041
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55608
Appears in Collections:中国药物依赖性研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China
2.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
3.Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, Yang,Lu, Tianlan,Yan, Hao,et al. Replication of Association between Schizophrenia and Chromosome 6p21-6p22.1 Polymorphisms in Chinese Han Population[J]. PLOS ONE,2013,8(2).
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhang, Yang]'s Articles
[Lu, Tianlan]'s Articles
[Yan, Hao]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhang, Yang]‘s Articles
[Lu, Tianlan]‘s Articles
[Yan, Hao]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace