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Replication of Association between Schizophrenia and Chromosome 6p21-6p22.1 Polymorphisms in Chinese Han Population
Zhang, Yang1,2,3; Lu, Tianlan2,3; Yan, Hao2,3; Ruan, Yanyan2,3; Wang, Lifang2,3; Zhang, Dai2,3; Yue, Weihua2,3; Lu, Lin1
刊名PLOS ONE
2013-02-21
DOI10.1371/journal.pone.0056732
8期:2
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]GENOME-WIDE ASSOCIATION ; SUSCEPTIBILITY GENE ; JAPANESE PATIENTS ; LINKAGE ANALYSES ; COMMON VARIANTS ; SCAN DOMAIN ; LOCUS ; 6P ; RISK ; HLA
英文摘要

Chromosome 6p21-p22.1, spanning the extended major histocompatibility complex (MHC) region, is a highly polymorphic, gene-dense region. It has been identified as a susceptibility locus of schizophrenia in Europeans, Japanese, and Chinese. In our previous two-stage genome-wide association study (GWAS), polymorphisms of zinc finger with KRAB and SCAN domains 4 (ZKSCAN4), nuclear factor-kappa B-activating protein-like (NKAPL), and piggyBac transposable element derived 1 (PGBD1), localized to chromosome 6p21-p22.1, were strongly associated with schizophrenia. To further investigate the association between polymorphisms at this locus and schizophrenia in the Chinese Han population, we selected eight other single-nucleotide polymorphisms (SNPs) distributed in or near these genes for a case-control association study in an independent sample of 902 cases and 1,091 healthy controls in an attempt to replicate the GWAS results. Four of these eight SNPs (rs12214383, rs1150724, rs3800324, and rs1997660) displayed a nominal difference in allele frequencies between the case and control groups. The association between two of these SNPs and schizophrenia were significant even after Bonferroni correction (rs12000: allele A. G, P = 2.50E-04, odds ratio [OR] = 1.27, 95% confidence interval [CI] = 1.12-1.45; rs1150722: allele C. T, P = 4.28E-05, OR = 0.55, 95% CI = 0.41-0.73). Haplotype ATTGACGC, comprising these eight SNPs (rs2235359, rs2185955, rs12214383, rs12000, rs1150724, rs1150722, rs3800324, and rs1997660), was significantly associated with schizophrenia (P = 6.60E-05). We also performed a combined study of this replication sample and the first-stage GWAS sample. The combined study revealed that rs12000 and rs1150722 were still strongly associated with schizophrenia (rs12000: allele G. A, P-combined = 0.0019, OR = 0.81; rs1150722: allele G. A, P-combined = 3.00E-04, OR = 0.61). These results support our findings that locus 6p21-p22.1 is significantly associated with schizophrenia in the Chinese Han population and encourage further studies of the functions of these genetic factors.

语种英语
WOS记录号WOS:000315186000041
项目编号81071087 ; 81071088 ; 2010DFB30820
资助机构National Natural Science Foundation of China ; International Science &amp ; Technology Cooperation Program of China
引用统计
被引频次:36[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55608
专题中国药物依赖性研究所
北京大学第一临床医学院_妇产科
北京大学精神卫生研究所_精神科
北京大学精神卫生研究所_生化室
作者单位1.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China
2.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
3.Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Yang,Lu, Tianlan,Yan, Hao,et al. Replication of Association between Schizophrenia and Chromosome 6p21-6p22.1 Polymorphisms in Chinese Han Population[J]. PLOS ONE,2013,8(2).
APA Zhang, Yang.,Lu, Tianlan.,Yan, Hao.,Ruan, Yanyan.,Wang, Lifang.,...&Lu, Lin.(2013).Replication of Association between Schizophrenia and Chromosome 6p21-6p22.1 Polymorphisms in Chinese Han Population.PLOS ONE,8(2).
MLA Zhang, Yang,et al."Replication of Association between Schizophrenia and Chromosome 6p21-6p22.1 Polymorphisms in Chinese Han Population".PLOS ONE 8.2(2013).
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