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学科主题: 临床医学
题名:
Effects of raloxifene hydrochloride on bone mineral density, bone metabolism and serum lipids in postmenopausal women: a randomized clinical trial in Beijing
作者: Zheng, SR; Wu, YY; Zhang, ZL; Yang, X; Hui, Y; Zhang, Y; Chen, SL; Deng, WH; Liu, H; Stocks, AEJ; Harper, K; Liu, JL
关键词: raloxifene ; bone mineral density ; metabolism ; lipids ; postmenopause
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2003-08-01
卷: 116, 期:8, 页:1127-1133
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: HORMONE REPLACEMENT THERAPY ; VERTEBRAL FRACTURE RISK ; BREAST-CANCER ; OSTEOPOROSIS ; ESTROGEN ; ENDOMETRIUM ; REDUCTION ; PLACEBO
英文摘要:

Objective To determine the effects of raloxifene hydrochloride (RLX) on bone mineral density (BMD), bone metabolism markers and serum lipids in healthy postmenopausal women in Beijing.

Methods A multicenter, randomized, double-blind, placebo-controlled study was conducted in a total of 204 healthy postmenopausal women (age 59.5 +/-5.0 years and weight 62.8 +/-8.7 kg) treated with either RLX 60 mg (n = 102) or placebo (n = 102) daily for 12 months. BMD, serum lipids, and bone markers were measured before and after drug administration.

Results Compared with placebo, RLX produced a significant increase in both total lumbar spine and total hip BMD. For the lumbar spine, percentage increase in total BMD was 2.3% with RLX compared with a decrease of 0.1% with placebo (P < 0.001). Corresponding values for total hip BMD were a 2.5% increase for RLX and a 1.1% increase for placebo (P = 0.011). For biochemical markers of bone metabolism, serum osteocalcin and C-telopeptide, percentage decreases were 27.65% and 24.02% in RLX-treated subjects. Corresponding values in placebo were a 10.64% decrease and a 15.75% increase (RLX compared with placebo, both P < 0.001). For total cholesterol and low-density lipoprotein cholesterol levels, percentage decreases were 6.44% and 34.58% in the RLX-treated group. Corresponding values in placebo-treated patients were a 1.44% increase and a 19.07% decrease (RLX compared with placebo, both P < 0.001). No differences were found for high-density lipoprotein cholesterol or triglyceride levels between the two groups. Only 5 subjects discontinued early owing to an adverse event (3 in the RLX group and 2 in the placebo group).

Conclusions This study confirms that RLX exerts positive effects on the skeleton, increasing BMD and decreasing biochemical markers of bone metabolism, and has a positive effect on the overall serum lipid profile in postmenopausal women in China.

语种: 英语
WOS记录号: WOS:000185174400002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55628
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Beijing Hosp, Dept Obstet & Gynaecol, Beijing 100730, Peoples R China
2.Eli Lilly & Co, Indianapolis, IN 46285 USA
3.Peking Univ, Dept Obstet & Gynaecol, Hosp 1, Beijing 100034, Peoples R China
4.Gen Hosp PLA, Dept Obstet & Gynaecol, Beijing 100853, Peoples R China

Recommended Citation:
Zheng, SR,Wu, YY,Zhang, ZL,et al. Effects of raloxifene hydrochloride on bone mineral density, bone metabolism and serum lipids in postmenopausal women: a randomized clinical trial in Beijing[J]. CHINESE MEDICAL JOURNAL,2003,116(8):1127-1133.
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