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学科主题: 基础医学
题名:
Shear Stress-Initiated Signaling and Its Regulation of Endothelial Function
作者: Zhou, Jing1,2,3; Li, Yi-Shuan2,3; Chien, Shu2,3
关键词: atherosclerosis ; cellular mechanotransduction ; hemodynamics
刊名: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
发表日期: 2014-10-01
DOI: 10.1161/ATVBAHA.114.303422
卷: 34, 期:10, 页:2191-2198
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Peripheral Vascular Disease
研究领域[WOS]: Hematology ; Cardiovascular System & Cardiology
关键词[WOS]: NITRIC-OXIDE SYNTHASE ; SMOOTH-MUSCLE-CELLS ; INTERCELLULAR-ADHESION MOLECULE-1 ; HUMAN ATHEROSCLEROTIC PLAQUES ; KRUPPEL-LIKE FACTOR-2 ; FACTOR-KAPPA-B ; DISTURBED FLOW ; IN-VIVO ; STIMULATES PHOSPHORYLATION ; MONOCYTE ADHESION
英文摘要:

Atherosclerosis develops preferentially at branches and curvatures of the arterial tree, where blood flow pattern is disturbed rather than being laminar, and wall shear stress has an irregular distribution without defined directions. The endothelium in the atherosusceptible regions, in comparison to that in atheroresistant regions, shows activation of proproliferative and proinflammatory gene expressions, reduced production of nitric oxide (NO), increased leukocyte adhesion, and permeability, as well as other atheroprone phenotypes. Differences in gene expressions and cell phenotypes have been detected in endothelia residing in native atherosusceptible and atheroresistant regions of the arteries, or in arteries from animal models with artificial creation of disturbed flow. Similar results have also been shown in in vitro systems that apply controlled shear stresses with or without clear directions to cultured endothelial cells in fluid-dynamically designed flow-loading devices. The available evidence indicates that the coordination of multiple signaling networks, rather than individual separate pathways, links the mechanical signals to specific genetic circuitries in orchestrating the mechanoresponsive networks to evoke comprehensive genetic and functional responses.

语种: 英语
所属项目编号: HL106579 ; HL108735 ; HL121365
项目资助者: National Institutes of Health
WOS记录号: WOS:000344056100007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55630
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Peking Univ, Basic Med Coll, Dept Physiol & Pathophysiol, Beijing 100871, Peoples R China
2.Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA
3.Univ Calif San Diego, Inst Engn Med, La Jolla, CA 92093 USA

Recommended Citation:
Zhou, Jing,Li, Yi-Shuan,Chien, Shu. Shear Stress-Initiated Signaling and Its Regulation of Endothelial Function[J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY,2014,34(10):2191-2198.
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