IR@PKUHSC  > 北京大学药学院
学科主题药学
Genetic, biological and structural hierarchies during sponge spicule formation: from soft sol-gels to solid 3D silica composite structures
Wang, Xiaohong1,2; Schroeder, Heinz C.1; Wang, Kui3; Kaandorp, Jaap A.4; Mueller, Werner E. G.1
刊名SOFT MATTER
2012
DOI10.1039/c2sm25889g
8期:37页:9501-9518
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Chemistry, Physical ; Materials Science, Multidisciplinary ; Physics, Multidisciplinary ; Polymer Science
资助者ERC Advanced Investigator Grant ; German Bundesministerium fur Bildung und Forschung (project "Center of Excellence BIOTECmarin") ; Deutsche Forschungsgemeinschaft ; European Commission ; International Human Frontier Science Program ; Public Welfare Project of Ministry of Land and Resources of the People&prime ; s Republic of China ; International S &amp ; T Cooperation Program of China ; ERC Advanced Investigator Grant ; German Bundesministerium fur Bildung und Forschung (project "Center of Excellence BIOTECmarin") ; Deutsche Forschungsgemeinschaft ; European Commission ; International Human Frontier Science Program ; Public Welfare Project of Ministry of Land and Resources of the People&prime ; s Republic of China ; International S &amp ; T Cooperation Program of China
研究领域[WOS]Chemistry ; Materials Science ; Physics ; Polymer Science
关键词[WOS]DEMOSPONGE SUBERITES-DOMUNCULA ; SEA HEXACTINELLID MONORHAPHIS ; CATHEPSIN-L ; GEODIA-CYDONIUM ; GIANT SPICULES ; DIATOM FRUSTULE ; BIOGENIC SILICA ; AXIAL FILAMENT ; BIO-SILICA ; IN-VITRO
英文摘要

Structural biomaterials are hierarchically organized and biofabricated. Although the structural complexity of most bioskeletons can be traced back from the millimeter-scale to the micrometer- or submicrometer-scale, the biological and/or genetic basis controlling the synthesis of these skeletons and their building blocks remained unknown. There is one distinguished example, the spicules of the siliceous sponges, for which the principle molecules and molecular-biological processes involved in their formation have been elucidated in the last few years. In this review, recent data on the different levels of molecular, biological and structural hierarchies controlling the synthesis of the picturesquely and intricately architectured spicules are summarized. The silicateins and their interacting/maturated proteins comprise the basic enzymatic/proteinous machinery that facilitates the polycondensation of silicate to biosilica. Two isoforms of silicatein, silicatein-alpha and silicatein-beta, the enzyme that catalyzes the polymerization of orthosilicate to polymeric biosilica, have been identified. The remarkable feature of these enzymes is that, besides their enzymatic function, they act as structure-giving proteins that provide the platform for the organization of the silica spicules. Silicatein-alpha together with silicatein-beta forms pentameric units that continue to grow in a linear pattern. The silicatein-interacting protein, silintaphin-1, stabilizes the initially formed silicatein fractals, while silintaphin-2 provides Ca2+ ions required for the appositional growth of the spicules. The biosilica formed during the enzymatically driven sol-gel process that is catalyzed by this multi-protein system is a soft, gel-like inorganic polymer. This soft biosilica undergoes a biologically controlled process of syneresis, resulting in a shrinkage of the silica network. During this reaction the biosilica is transformed into an elastic solid and gains the characteristic spicule morphology. A sizeable amount of protein, mostly silicatein, remains embedded in the biosilica material, thus forming a hybrid bioinorganic ("biosilica") material. The process of syneresis involves the removal of water by cell-membrane-associated aquaporin channels and is guided by collagen bundles. Four cell types, sclerocytes, archaeocytes, chromocytes and lophocytes, participate in this structure-guiding process. In conclusion, this article attempts to overcome the frontiers in the understanding of the different levels of hierarchies, genetic, biological and structural, and to contribute towards the fabrication of new bioinspired functional materials.

语种英语
所属项目编号268476 ; Schr 277/10-2 ; 311848 ; 286059 ; 246987 ; 244967 ; 215507-2 ; 266033 ; 201011005-06 ; 2008DFA00980
资助者ERC Advanced Investigator Grant ; German Bundesministerium fur Bildung und Forschung (project "Center of Excellence BIOTECmarin") ; Deutsche Forschungsgemeinschaft ; European Commission ; International Human Frontier Science Program ; Public Welfare Project of Ministry of Land and Resources of the People&prime ; s Republic of China ; International S &amp ; T Cooperation Program of China ; ERC Advanced Investigator Grant ; German Bundesministerium fur Bildung und Forschung (project "Center of Excellence BIOTECmarin") ; Deutsche Forschungsgemeinschaft ; European Commission ; International Human Frontier Science Program ; Public Welfare Project of Ministry of Land and Resources of the People&prime ; s Republic of China ; International S &amp ; T Cooperation Program of China
WOS记录号WOS:000308095700001
引用统计
被引频次:42[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55633
专题北京大学药学院
作者单位1.Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Physiol Chem, ERC Adv Grant Res Grp,Joint German Chinese Lab Na, D-55128 Mainz, Germany
2.Chinese Acad Sci, Natl Res Ctr Geoanal, Beijing 100037, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
4.Univ Amsterdam, Fac Sci, Sect Computat Sci, NL-1090 GE Amsterdam, Netherlands
推荐引用方式
GB/T 7714
Wang, Xiaohong,Schroeder, Heinz C.,Wang, Kui,et al. Genetic, biological and structural hierarchies during sponge spicule formation: from soft sol-gels to solid 3D silica composite structures[J]. SOFT MATTER,2012,8(37):9501-9518.
APA Wang, Xiaohong,Schroeder, Heinz C.,Wang, Kui,Kaandorp, Jaap A.,&Mueller, Werner E. G..(2012).Genetic, biological and structural hierarchies during sponge spicule formation: from soft sol-gels to solid 3D silica composite structures.SOFT MATTER,8(37),9501-9518.
MLA Wang, Xiaohong,et al."Genetic, biological and structural hierarchies during sponge spicule formation: from soft sol-gels to solid 3D silica composite structures".SOFT MATTER 8.37(2012):9501-9518.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Xiaohong]的文章
[Schroeder, Heinz C.]的文章
[Wang, Kui]的文章
百度学术
百度学术中相似的文章
[Wang, Xiaohong]的文章
[Schroeder, Heinz C.]的文章
[Wang, Kui]的文章
必应学术
必应学术中相似的文章
[Wang, Xiaohong]的文章
[Schroeder, Heinz C.]的文章
[Wang, Kui]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。