|Prevalence of microvascular diseases among tertiary care Chinese with early versus late onset of type 2 diabetes|
|Li, Ling1; Ji, Linong2; Guo, Xiaohui3; Ji, Qiuhe4; Gu, Weijun5; Zhi, Xinyue1; Li, Xing6; Kuang, Hongyu7; Su, Benli8; Yan, Jinhua9; Yang, Xilin1|
|关键词||Chinese Early-onset Microvascular Diseases Prevalence Type 2 Diabetes Mellitus|
|刊名||JOURNAL OF DIABETES AND ITS COMPLICATIONS|
|WOS标题词||Science & Technology|
|类目[WOS]||Endocrinology & Metabolism|
|研究领域[WOS]||Endocrinology & Metabolism|
|关键词[WOS]||IMPAIRED GLUCOSE-TOLERANCE ; BLOOD-GLUCOSE ; RISK-FACTORS ; LIFE-STYLE ; COMPLICATIONS ; YOUNG ; MELLITUS ; ASSOCIATION ; RETINOPATHY ; PREVENTION|
Aims: This study aimed to investigate the impact of early-onset diabetes on the risk of microvascular diseases in Chinese with type 2 diabetes mellitus (T2DM).
Methods: A cross sectional survey of 29,442 patients with T2DM in 77 tertiary hospitals in China was conducted in 2011. Early-onset diabetes was defined as diagnosis of diabetes before 40 years of age. Microvascular complications and risk factors were documented. Prevalence of microvascular disease was standardized to the Chinese population in 2010. Logistic regression analysis was performed to obtain odds ratios (OR) for early versus late onset of T2DM.
Results: A total of 1,303 (4.4%) patients had nephropathy, 2,137 (7.3%) had retinopathy and 3,012 (10.2%) had either of them. Early-onset diabetes greatly increased the prevalence of microvascular diseases compared with late-onset diabetes (nephropathy: 5.1% vs. 1.5%; retinopathy: 7.1% vs. 2.7%; either: 9.7% vs. 3.6%), especially among patients from 45 to 59 years of age. After adjusting for age and sex, patients with early-onset T2DM were at 1.69-fold (95% CI 1.46-1.95) higher risk of microvascular diseases than those with late-onset T2DM. However, this was not significant after adjusting for traditional risk factors and disease duration (p = 0.162).
Conclusion: Chinese patients with early-onset T2DM are at a marked increased risk of microvascular diseases. (C) 2015 Elsevier Inc. All rights reserved.
|资助机构||Novo Nordisk China|
|作者单位||1.Tianjin Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Tianjin 300070, Peoples R China|
2.Peking Univ, Peoples Hosp, Dept Endocrinol & Metab, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 1, Dept Endocrinol, Beijing 100871, Peoples R China
4.4th Mil Med Univ, Xijing Hosp, Dept Endocrinol, Xian, Peoples R China
5.Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, Beijing, Peoples R China
6.Shanxi Med Univ, Hosp 2, Dept Endocrinol, Taiyuan, Peoples R China
7.Harbin Med Univ, Affiliated Hosp 1, Dept Endocrinol, Harbin, Peoples R China
8.Dalian Med Univ, Affiliated Hosp 2, Dept Endocrinol, Dalian, Peoples R China
9.Sun Yat Sen Univ, Affiliated Hosp 3, Dept Endocrinol, Guangzhou 510275, Guangdong, Peoples R China
|Li, Ling,Ji, Linong,Guo, Xiaohui,et al. Prevalence of microvascular diseases among tertiary care Chinese with early versus late onset of type 2 diabetes[J]. JOURNAL OF DIABETES AND ITS COMPLICATIONS,2015,29(1):32-37.|
|APA||Li, Ling.,Ji, Linong.,Guo, Xiaohui.,Ji, Qiuhe.,Gu, Weijun.,...&Yang, Xilin.(2015).Prevalence of microvascular diseases among tertiary care Chinese with early versus late onset of type 2 diabetes.JOURNAL OF DIABETES AND ITS COMPLICATIONS,29(1),32-37.|
|MLA||Li, Ling,et al."Prevalence of microvascular diseases among tertiary care Chinese with early versus late onset of type 2 diabetes".JOURNAL OF DIABETES AND ITS COMPLICATIONS 29.1(2015):32-37.|