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学科主题: 临床医学
题名:
Downregulated microRNA-510-5p acts as a tumor suppressor in renal cell carcinoma
作者: Chen, Duqun1,2,3; Li, Yuchi1,2,4; Yu, Zuhu1,2,3; Li, Yifan1,2,3; Su, Zhengming1,2,4; Ni, Liangchao1,2; Yang, Shangqi1,2; Gui, Yaoting2; Lai, Yongqing1,2
关键词: microRNA-510 ; renal cell carcinoma ; tumor suppressor
刊名: MOLECULAR MEDICINE REPORTS
发表日期: 2015-08-01
DOI: 10.3892/mmr.2015.3704
卷: 12, 期:2, 页:3061-3066
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Medicine, Research & Experimental
研究领域[WOS]: Oncology ; Research & Experimental Medicine
关键词[WOS]: CANCER-DIAGNOSIS ; EXPRESSION ; DISCOVERY ; SURVIVAL ; MICROARRAYS ; METASTASIS ; PROGNOSIS ; BIOMARKER ; RESECTION ; TARGETS
英文摘要:

MicroRNA (miR)-510-5p has been demonstrated to be involved in a number of types of malignancy; however, the function of miR-510-5p in renal cancer remains unclear. The present study aimed to determine the expression of miR-510-5p in renal cell carcinoma (RCC) specimens and analyzed the impact of miR-510-5p on renal cancer by 3-(4,5dimethylthi-azol-2-yl)-2,5-diphenyltetrazolium bromide, wound scratch and apoptosis assays. The results showed that miR-510-5p was significantly downregulated in RCC specimens compared with normal renal specimens. Overexpression of miR-510-5p by synthetic mature mimics reduced cell proliferation and migration and induced an increase in cell apoptosis, indicating that miR-510-5p may act as a tumor suppressor in RCC. The present study firstly revealed that downregulated miR-510-5p functioned as a tumor suppressor by reducing cellular proliferation and migration, and inducing apoptosis in RCC. Further research is required to define target genes of miR-510-5p to determine the cellular mechanism of miR-510-5p in the carcinogenesis of RCC.

语种: 英语
所属项目编号: 81101922 ; A2012584 ; A2013606 ; JCYJ20130402114702124
项目资助者: National Natural Science Foundation of China ; Medical Scientific Research Foundation of Guangdong Province of China ; Science and Technology Development Fund Project of Shenzhen ; Guandong Key medical subject
WOS记录号: WOS:000358678600198
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55641
Appears in Collections:北京大学深圳医院_泌尿外科_期刊论文

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作者单位: 1.Peking Univ, Shenzhen Hosp, Dept Urol, Shenzhen 518036, Guangdong, Peoples R China
2.Shenzhen PKU HKUST Med Ctr, Inst Urol, Guangdong & Shenzhen Key Lab Male Reprod Med & Ge, Shenzhen 518036, Guangdong, Peoples R China
3.Anhui Med Univ, Affiliated Hosp 1, Dept Urol, Hefei 230032, Anhui, Peoples R China
4.Shantou Univ, Coll Med, Dept Urol, Shantou 515041, Guangdong, Peoples R China

Recommended Citation:
Chen, Duqun,Li, Yuchi,Yu, Zuhu,et al. Downregulated microRNA-510-5p acts as a tumor suppressor in renal cell carcinoma[J]. MOLECULAR MEDICINE REPORTS,2015,12(2):3061-3066.
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