IR@PKUHSC  > 北京大学深圳医院  > 泌尿外科
学科主题临床医学
Downregulated microRNA-510-5p acts as a tumor suppressor in renal cell carcinoma
Chen, Duqun1,2,3; Li, Yuchi1,2,4; Yu, Zuhu1,2,3; Li, Yifan1,2,3; Su, Zhengming1,2,4; Ni, Liangchao1,2; Yang, Shangqi1,2; Gui, Yaoting2; Lai, Yongqing1,2
关键词Microrna-510 Renal Cell Carcinoma Tumor Suppressor
刊名MOLECULAR MEDICINE REPORTS
2015-08-01
DOI10.3892/mmr.2015.3704
12期:2页:3061-3066
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Medicine, Research & Experimental
研究领域[WOS]Oncology ; Research & Experimental Medicine
关键词[WOS]CANCER-DIAGNOSIS ; EXPRESSION ; DISCOVERY ; SURVIVAL ; MICROARRAYS ; METASTASIS ; PROGNOSIS ; BIOMARKER ; RESECTION ; TARGETS
英文摘要

MicroRNA (miR)-510-5p has been demonstrated to be involved in a number of types of malignancy; however, the function of miR-510-5p in renal cancer remains unclear. The present study aimed to determine the expression of miR-510-5p in renal cell carcinoma (RCC) specimens and analyzed the impact of miR-510-5p on renal cancer by 3-(4,5dimethylthi-azol-2-yl)-2,5-diphenyltetrazolium bromide, wound scratch and apoptosis assays. The results showed that miR-510-5p was significantly downregulated in RCC specimens compared with normal renal specimens. Overexpression of miR-510-5p by synthetic mature mimics reduced cell proliferation and migration and induced an increase in cell apoptosis, indicating that miR-510-5p may act as a tumor suppressor in RCC. The present study firstly revealed that downregulated miR-510-5p functioned as a tumor suppressor by reducing cellular proliferation and migration, and inducing apoptosis in RCC. Further research is required to define target genes of miR-510-5p to determine the cellular mechanism of miR-510-5p in the carcinogenesis of RCC.

语种英语
WOS记录号WOS:000358678600198
项目编号81101922 ; A2012584 ; A2013606 ; JCYJ20130402114702124
资助机构National Natural Science Foundation of China ; Medical Scientific Research Foundation of Guangdong Province of China ; Science and Technology Development Fund Project of Shenzhen ; Guandong Key medical subject
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55641
专题北京大学深圳医院_泌尿外科
北京大学第一临床医学院_泌尿外科
作者单位1.Peking Univ, Shenzhen Hosp, Dept Urol, Shenzhen 518036, Guangdong, Peoples R China
2.Shenzhen PKU HKUST Med Ctr, Inst Urol, Guangdong & Shenzhen Key Lab Male Reprod Med & Ge, Shenzhen 518036, Guangdong, Peoples R China
3.Anhui Med Univ, Affiliated Hosp 1, Dept Urol, Hefei 230032, Anhui, Peoples R China
4.Shantou Univ, Coll Med, Dept Urol, Shantou 515041, Guangdong, Peoples R China
推荐引用方式
GB/T 7714
Chen, Duqun,Li, Yuchi,Yu, Zuhu,et al. Downregulated microRNA-510-5p acts as a tumor suppressor in renal cell carcinoma[J]. MOLECULAR MEDICINE REPORTS,2015,12(2):3061-3066.
APA Chen, Duqun.,Li, Yuchi.,Yu, Zuhu.,Li, Yifan.,Su, Zhengming.,...&Lai, Yongqing.(2015).Downregulated microRNA-510-5p acts as a tumor suppressor in renal cell carcinoma.MOLECULAR MEDICINE REPORTS,12(2),3061-3066.
MLA Chen, Duqun,et al."Downregulated microRNA-510-5p acts as a tumor suppressor in renal cell carcinoma".MOLECULAR MEDICINE REPORTS 12.2(2015):3061-3066.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Chen, Duqun]的文章
[Li, Yuchi]的文章
[Yu, Zuhu]的文章
百度学术
百度学术中相似的文章
[Chen, Duqun]的文章
[Li, Yuchi]的文章
[Yu, Zuhu]的文章
必应学术
必应学术中相似的文章
[Chen, Duqun]的文章
[Li, Yuchi]的文章
[Yu, Zuhu]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。