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学科主题: 基础医学
题名:
Increased iron deposition in rat liver fibrosis induced by a high-dose injection of dimethylnitrosamine
作者: Guo, Limei; Enzan, Hideaki; Hayashi, Yoshihiro; Miyazaki, Eriko; Jin, Yulan; Toi, Makoto; Kuroda, Naoto; Hiroi, Makoto
关键词: iron ; liver fibrosis ; hepatic stellate cells ; macrophages ; transforming growth factor beta(1)
刊名: EXPERIMENTAL AND MOLECULAR PATHOLOGY
发表日期: 2006-12-01
DOI: 10.1016/j.yexmp.2006.07.006
卷: 81, 期:3, 页:255-261
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pathology
研究领域[WOS]: Pathology
关键词[WOS]: HEPATIC STELLATE CELLS ; HEPATOCELLULAR-CARCINOMA ; ITO CELLS ; EXPRESSION ; NECROSIS ; HEMOCHROMATOSIS ; PROLIFERATION ; FIBROGENESIS ; CIRRHOSIS ; GENE
英文摘要:

Using a developed rat model of hepatic necrosis and subsequent fibrosis induced by a high-dose intraperitoneal injection of dimethylnitrosamine (DMN), we studied iron deposition and expression of transforming growth factor-beta(1) (TGF-beta(1)) during the development of persistent liver fibrosis. Rats were sacrificed at several timepoints from 6 h to 10 months post-injection and the livers were examined for iron content and distribution, and for expression of alpha-smooth muscle actin, ED-1, TGF-beta 1, and collagen (alpha 2)I. Morphologic evidence of acute submassive hemorrhagic necrosis peaked at 36 h; on day 3 the residual parenchyma contained activated hepatic stellate cells (HSCs) and necrotic areas contained numerous macrophages; and on day 5, necrotic tissues and erythrocytes had been phagocytosed and macrophages contained abundant iron deposits. From days 7 to 10, iron-laden macrophages and activated HSCs (myofibroblasts) populated the fibrous septa in parallel. From week 2 to month 10, closely arranged macrophages and myofibroblasts were found in central-to-central bridging fibrotic tissue. TGF beta(1) was strongly detected in both macrophages and HSCs during development of liver fibrosis. Our data suggest that increased iron deposition may be involved in the initiation and perpetuation of rat liver fibrosis. Iron-laden macrophages may influence HSCs through the action of TGF-beta(1) in DMN-induced liver fibrosis. (c) 2006 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000242299900012
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55642
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Peking Univ, Ctr Hlth Sci, Dept Pathol, Beijing 100083, Peoples R China
2.Kochi Univ, Sch Med, Dept Pathol, Kochi 780, Japan

Recommended Citation:
Guo, Limei,Enzan, Hideaki,Hayashi, Yoshihiro,et al. Increased iron deposition in rat liver fibrosis induced by a high-dose injection of dimethylnitrosamine[J]. EXPERIMENTAL AND MOLECULAR PATHOLOGY,2006,81(3):255-261.
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