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学科主题: 临床医学
题名:
The Effects of Pioglitazone on Biochemical Markers of Bone Turnover in the Patients with Type 2 Diabetes
作者: Xiao, Wen-hua1; Wang, Yan-rong1; Hou, Wen-fang1; Xie, Chao1; Wang, Hai-ning1; Hong, Tian-pei1; Gao, Hong-wei1,2
刊名: INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
发表日期: 2013
DOI: 10.1155/2013/290734
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: MINERAL DENSITY ; OSTEOBLAST DIFFERENTIATION ; CONTROLLED-TRIAL ; ROSIGLITAZONE ; RISK ; DECREASES ; FRACTURE ; WOMEN ; THIAZOLIDINEDIONES ; ACTIVATION
英文摘要:

Aim. To investigate whether pioglitazone had detrimental effects on biochemical markers of bone turnover in patients with type 2 diabetes (T2DM). Methods. Seventy patients with T2DM were included in this study. The patients remained on their previous antihyperglycemic therapies during the trial. Pioglitazone was then added on their regimen for 3 months. Results. After 3 months of treatment with pioglitazone, the levels of fasting blood glucose and HbA(1c) were significantly decreased (7.9 +/- 1.5 mmol/L versus 9.1 +/- 1.6 mmol/L and 7.1 +/- 1.0% versus 8.2 +/- 1.4%, resp., P < 0.01), compared with baseline in the overall patients. Serum concentrations of P1NP and BAP were significantly decreased from baseline (45.0 +/- 20.0 mu g/L versus 40.6 +/- 17.9 mu g/L and 13.23 +/- 4.7 mu g/L versus 12.3 +/- 5.0 mu g/L, resp., P < 0.01) in female group, but not in male group. The serum levels of OC and CTX were unchanged in both female and male subgroups. In addition, the levels of serum BAP and P1NP were significantly decreased after pioglitazone treatment in postmenopausal subgroup, comparing with baseline. Conclusion. Pioglitazone inhibits bone formation and does not seem to affect bone resorption. Postmenopausal female patients rather than premenopausal or male patients are particularly vulnerable to this side effect of pioglitazone.

语种: 英语
所属项目编号: 7123234 ; 2006CB503908 ; 2006AA02A112 ; 30771032 ; 30700879 ; 81070701 ; 81000315
项目资助者: Beijing Natural Science Foundation ; Chinese National 973 Program ; Chinese National 863 Program ; National Natural Science Foundation of China ; East China Pharmaceutical Company, Hangzhou, China
WOS记录号: WOS:000321353800001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55644
Appears in Collections:北京大学第三临床医学院_内分泌科_期刊论文

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作者单位: 1.Peking Univ, Dept Endocrinol, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Dept Endocrinol & Metab, Hosp 3, Beijing 100191, Peoples R China

Recommended Citation:
Xiao, Wen-hua,Wang, Yan-rong,Hou, Wen-fang,et al. The Effects of Pioglitazone on Biochemical Markers of Bone Turnover in the Patients with Type 2 Diabetes[J]. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY,2013.
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