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IR@PKUHSC  > 北京大学临床肿瘤学院  > 胸外科  > 期刊论文
学科主题: 临床医学
题名:
Expression of Sonic Hedgehog (SHH) in Human Lung Cancer and the Impact of YangZheng XiaoJi on SHH-mediated Biological Function of Lung Cancer Cells and Tumor Growth
作者: Jiang, Wen G.1; Ye, Lin1; Ruge, Fiona1; Sun, Ping-Hui1; Sanders, Andrew J.1; Ji, Ki1; Lane, Jane1; Zhang, Lijian2; Satherley, Lucy1; Weeks, Hoi P.1; Zhi, Xiuyi3,4; Gao, Yong5; Wei, Cong5; Wu, Yiling5; Mason, Malcolm D.1
关键词: Sonic hedgehog (SHH) ; lung cancer ; tumor model ; YangZheng XiaoJi ; cellular migration ; invasion ; cyclopamine ; Smo ; Gli
刊名: ANTICANCER RESEARCH
发表日期: 2015-03-01
卷: 35, 期:3, 页:1321-1331
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: HUMAN BREAST-CANCER ; SIGNALING PATHWAY ; PANCREATIC-CANCER ; IN-VIVO ; HGF/SF ANTAGONIST ; ACTIVATION ; MOLECULES ; ANGIOGENESIS ; INHIBITION ; CARCINOMAS
英文摘要:

Sonic Hedgehog (SHH) is a protein that is aberrantly expressed in various human tumors. SHH and its signaling molecules have been indicated as potential therapeutic targets. In the present study, we evaluated the expression of SHH transcript in human non-small cell lung cancer (NSCLC) tissues and investigated the impact of inhibiting SHH together with a traditional Chinese medicine formula, YangZheng XiaoJi (YZXJ), on the function and growth of lung cancer cells. Human NSCLC tissues had significantly higher levels of the SHH transcript compared matched normal lung tissues (n=83). TNM2 tumors and tumors with pleural invasion had higher levels than TNM1 and non-invasive tumors. High SHH levels were associated with a shorter overall survival (OS) of the patients. A SHH inhibitor, cyclopamine, and YZXJ alone or in combination had a marked inhibitory effect on cellular invasion and cellular migration of human lung cancer cells, A549 and SKMES1 YangZheng XiaoJi and its combination with cyclopamine also significantly reduced the growth of lung tumors in vivo together with a reduction of SHH and smoothened (Smo) proteins in the lung tumors. The present study provides evidence that blocking SHH by way of small inhibitor and by YangZheng XiaoJi has a profound influence on lung cancer cells as seen by in vitro invasion and cell migration and in vivo tumor growth. Together with the aberrant expression of SHH in NSCLC tumors in the patients, it is suggested that SHH is a potential target for therapies Or NSCLC.

语种: 英语
项目资助者: Cancer Research Wales ; Albert Hung Foundation ; Ser Cymru Welsh Life Science Fund
WOS记录号: WOS:000352462900013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55645
Appears in Collections:北京大学临床肿瘤学院_胸外科_期刊论文

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作者单位: 1.Yiling Med Res Inst, Shijiazhuang, Hebei Province, Peoples R China
2.Peking Univ, Canc Hosp, Dept Thorac Surg, Beijing 100871, Peoples R China
3.Capital Med Univ, Inst Canc, Beijing, Peoples R China
4.Capital Med Univ, XuanWu Hosp, Dept Thorac Surg, Beijing, Peoples R China
5.Cardiff Univ, Sch Med, Cardiff Univ Peking Univ Canc Inst, Cardiff CF14 4XN, S Glam, Wales

Recommended Citation:
Jiang, Wen G.,Ye, Lin,Ruge, Fiona,et al. Expression of Sonic Hedgehog (SHH) in Human Lung Cancer and the Impact of YangZheng XiaoJi on SHH-mediated Biological Function of Lung Cancer Cells and Tumor Growth[J]. ANTICANCER RESEARCH,2015,35(3):1321-1331.
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