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Expression of Sonic Hedgehog (SHH) in Human Lung Cancer and the Impact of YangZheng XiaoJi on SHH-mediated Biological Function of Lung Cancer Cells and Tumor Growth
Jiang, Wen G.1; Ye, Lin1; Ruge, Fiona1; Sun, Ping-Hui1; Sanders, Andrew J.1; Ji, Ki1; Lane, Jane1; Zhang, Lijian2; Satherley, Lucy1; Weeks, Hoi P.1; Zhi, Xiuyi3,4; Gao, Yong5; Wei, Cong5; Wu, Yiling5; Mason, Malcolm D.1
关键词Sonic Hedgehog (Shh) Lung Cancer Tumor Model Yangzheng Xiaoji Cellular Migration Invasion Cyclopamine Smo Gli
刊名ANTICANCER RESEARCH
2015-03-01
35期:3页:1321-1331
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]HUMAN BREAST-CANCER ; SIGNALING PATHWAY ; PANCREATIC-CANCER ; IN-VIVO ; HGF/SF ANTAGONIST ; ACTIVATION ; MOLECULES ; ANGIOGENESIS ; INHIBITION ; CARCINOMAS
英文摘要

Sonic Hedgehog (SHH) is a protein that is aberrantly expressed in various human tumors. SHH and its signaling molecules have been indicated as potential therapeutic targets. In the present study, we evaluated the expression of SHH transcript in human non-small cell lung cancer (NSCLC) tissues and investigated the impact of inhibiting SHH together with a traditional Chinese medicine formula, YangZheng XiaoJi (YZXJ), on the function and growth of lung cancer cells. Human NSCLC tissues had significantly higher levels of the SHH transcript compared matched normal lung tissues (n=83). TNM2 tumors and tumors with pleural invasion had higher levels than TNM1 and non-invasive tumors. High SHH levels were associated with a shorter overall survival (OS) of the patients. A SHH inhibitor, cyclopamine, and YZXJ alone or in combination had a marked inhibitory effect on cellular invasion and cellular migration of human lung cancer cells, A549 and SKMES1 YangZheng XiaoJi and its combination with cyclopamine also significantly reduced the growth of lung tumors in vivo together with a reduction of SHH and smoothened (Smo) proteins in the lung tumors. The present study provides evidence that blocking SHH by way of small inhibitor and by YangZheng XiaoJi has a profound influence on lung cancer cells as seen by in vitro invasion and cell migration and in vivo tumor growth. Together with the aberrant expression of SHH in NSCLC tumors in the patients, it is suggested that SHH is a potential target for therapies Or NSCLC.

语种英语
WOS记录号WOS:000352462900013
资助机构Cancer Research Wales ; Albert Hung Foundation ; Ser Cymru Welsh Life Science Fund
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55645
专题北京大学临床肿瘤学院_胸外科
北京大学临床肿瘤学院_胸部肿瘤外二科
作者单位1.Yiling Med Res Inst, Shijiazhuang, Hebei Province, Peoples R China
2.Peking Univ, Canc Hosp, Dept Thorac Surg, Beijing 100871, Peoples R China
3.Capital Med Univ, Inst Canc, Beijing, Peoples R China
4.Capital Med Univ, XuanWu Hosp, Dept Thorac Surg, Beijing, Peoples R China
5.Cardiff Univ, Sch Med, Cardiff Univ Peking Univ Canc Inst, Cardiff CF14 4XN, S Glam, Wales
推荐引用方式
GB/T 7714
Jiang, Wen G.,Ye, Lin,Ruge, Fiona,et al. Expression of Sonic Hedgehog (SHH) in Human Lung Cancer and the Impact of YangZheng XiaoJi on SHH-mediated Biological Function of Lung Cancer Cells and Tumor Growth[J]. ANTICANCER RESEARCH,2015,35(3):1321-1331.
APA Jiang, Wen G..,Ye, Lin.,Ruge, Fiona.,Sun, Ping-Hui.,Sanders, Andrew J..,...&Mason, Malcolm D..(2015).Expression of Sonic Hedgehog (SHH) in Human Lung Cancer and the Impact of YangZheng XiaoJi on SHH-mediated Biological Function of Lung Cancer Cells and Tumor Growth.ANTICANCER RESEARCH,35(3),1321-1331.
MLA Jiang, Wen G.,et al."Expression of Sonic Hedgehog (SHH) in Human Lung Cancer and the Impact of YangZheng XiaoJi on SHH-mediated Biological Function of Lung Cancer Cells and Tumor Growth".ANTICANCER RESEARCH 35.3(2015):1321-1331.
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