IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Study on Malignant and Normal Rectum Tissues Using IR and H-1 and P-31 NMR Spectroscopy
Gao Xiu-xiang1; Yao Hong-wei2; Du Jun-kai3; Zhao Mei-xian1,4; Qi Jian1; Li Hui-zhen1,5; Pan Qing-hua1,6; Xu Yi-zhuang1; Wu Jin-guang1
关键词Magic Angle Spinning Nuclear Magnetic Resonance Rectum Cancer Early Diagnosis
刊名SPECTROSCOPY AND SPECTRAL ANALYSIS
2009-04-01
DOI10.3964/j.issn.1000-0593(2009)04-0969-05
29期:4页:969-973
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Spectroscopy
研究领域[WOS]Spectroscopy
关键词[WOS]MAGNETIC-RESONANCE-SPECTROSCOPY ; BLOOD-PLASMA ; IN-VIVO ; DIAGNOSIS ; METABOLISM ; CARCINOMA ; TUMOR
英文摘要

In the present paper, NMR spectroscopy, an effective tool to detect the variation in molecular structure and changes in chemical composition of metabolites in tissues, was used to study the differences between malignant and normal tissues from rectum. H-1 and P-31 spectra of seven malignant rectum tissue samples and five normal control tissues were investigated by using a 300 M NMR spectrometers and compared with the results of the infrared spectra of normal and malignant rectum organ tissues. The results indicate that the H-1 and P-31 spectra of rectum cancer tissues are significantly different from those of the normal controls and most differences present in the form of variation in relative intensities of the characteristic peaks of various metabolites. Systematic differences in the NMR spectra between malignant tissues and normal controls are as follows: in the H-1 NMR spectra, differences lie in fatty acids with the concentration of fatty acid decreasing significantly in malignant tissues. In the P-31 NMR spectra, differences lie in phospholipid, with the chemical shift of phospholipid decreasing significantly in malignant tissues. This phenomenon may reflect the fact that the activity of protein synthesis is enhanced in cancerous tissues. The difference in the chemical shift of phospholipid between normal rectal tissue and malignant tissue may be considered as a detection criterion. Therefore, the above spectral variations in P-31 NMR spectra may be utilized as a potential tool to diagnose rectum cancer.

语种中文
WOS记录号WOS:000264829600024
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55648
专题北京大学第三临床医学院
作者单位1.Peking Univ, Hosp 3, Beijing 100083, Peoples R China
2.Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
3.Xi An Jiao Tong Univ, Hosp 1, Xian 710061, Peoples R China
4.Beijing Univ Chem Technol, Sch Sci, Dept Appl Chem, Beijing 100029, Peoples R China
5.Henan Normal Univ, Coll Chem & Environm Sci, Xinxiang 453007, Peoples R China
6.Hangzhou Normal Univ, Hangzhou 310012, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714
Gao Xiu-xiang,Yao Hong-wei,Du Jun-kai,et al. Study on Malignant and Normal Rectum Tissues Using IR and H-1 and P-31 NMR Spectroscopy[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS,2009,29(4):969-973.
APA Gao Xiu-xiang.,Yao Hong-wei.,Du Jun-kai.,Zhao Mei-xian.,Qi Jian.,...&Wu Jin-guang.(2009).Study on Malignant and Normal Rectum Tissues Using IR and H-1 and P-31 NMR Spectroscopy.SPECTROSCOPY AND SPECTRAL ANALYSIS,29(4),969-973.
MLA Gao Xiu-xiang,et al."Study on Malignant and Normal Rectum Tissues Using IR and H-1 and P-31 NMR Spectroscopy".SPECTROSCOPY AND SPECTRAL ANALYSIS 29.4(2009):969-973.
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