北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Study on Malignant and Normal Rectum Tissues Using IR and H-1 and P-31 NMR Spectroscopy
作者: Gao Xiu-xiang1; Yao Hong-wei2; Du Jun-kai3; Zhao Mei-xian1,4; Qi Jian1; Li Hui-zhen1,5; Pan Qing-hua1,6; Xu Yi-zhuang1; Wu Jin-guang1
关键词: Magic angle spinning ; Nuclear magnetic resonance ; Rectum cancer ; Early diagnosis
刊名: SPECTROSCOPY AND SPECTRAL ANALYSIS
发表日期: 2009-04-01
DOI: 10.3964/j.issn.1000-0593(2009)04-0969-05
卷: 29, 期:4, 页:969-973
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Spectroscopy
研究领域[WOS]: Spectroscopy
关键词[WOS]: MAGNETIC-RESONANCE-SPECTROSCOPY ; BLOOD-PLASMA ; IN-VIVO ; DIAGNOSIS ; METABOLISM ; CARCINOMA ; TUMOR
英文摘要:

In the present paper, NMR spectroscopy, an effective tool to detect the variation in molecular structure and changes in chemical composition of metabolites in tissues, was used to study the differences between malignant and normal tissues from rectum. H-1 and P-31 spectra of seven malignant rectum tissue samples and five normal control tissues were investigated by using a 300 M NMR spectrometers and compared with the results of the infrared spectra of normal and malignant rectum organ tissues. The results indicate that the H-1 and P-31 spectra of rectum cancer tissues are significantly different from those of the normal controls and most differences present in the form of variation in relative intensities of the characteristic peaks of various metabolites. Systematic differences in the NMR spectra between malignant tissues and normal controls are as follows: in the H-1 NMR spectra, differences lie in fatty acids with the concentration of fatty acid decreasing significantly in malignant tissues. In the P-31 NMR spectra, differences lie in phospholipid, with the chemical shift of phospholipid decreasing significantly in malignant tissues. This phenomenon may reflect the fact that the activity of protein synthesis is enhanced in cancerous tissues. The difference in the chemical shift of phospholipid between normal rectal tissue and malignant tissue may be considered as a detection criterion. Therefore, the above spectral variations in P-31 NMR spectra may be utilized as a potential tool to diagnose rectum cancer.

语种: 中文
WOS记录号: WOS:000264829600024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55648
Appears in Collections:北京大学第三临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 3, Beijing 100083, Peoples R China
2.Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
3.Xi An Jiao Tong Univ, Hosp 1, Xian 710061, Peoples R China
4.Beijing Univ Chem Technol, Sch Sci, Dept Appl Chem, Beijing 100029, Peoples R China
5.Henan Normal Univ, Coll Chem & Environm Sci, Xinxiang 453007, Peoples R China
6.Hangzhou Normal Univ, Hangzhou 310012, Zhejiang, Peoples R China

Recommended Citation:
Gao Xiu-xiang,Yao Hong-wei,Du Jun-kai,et al. Study on Malignant and Normal Rectum Tissues Using IR and H-1 and P-31 NMR Spectroscopy[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS,2009,29(4):969-973.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Gao Xiu-xiang]'s Articles
[Yao Hong-wei]'s Articles
[Du Jun-kai]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Gao Xiu-xiang]‘s Articles
[Yao Hong-wei]‘s Articles
[Du Jun-kai]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace