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学科主题临床医学
Cell cycle-dependent expression of p42.3 promotes mitotic progression in malignant transformed cells
Mao, Linlin; Sun, Wei; Li, Wenmei; Cui, Jiantao; Zhang, Jingyu; Xing, Rui; Lu, Youyong
关键词P42.3 Cell Transformation Cell Cycle Early G1 Mitotic Progression
刊名MOLECULAR CARCINOGENESIS
2014-05-01
DOI10.1002/mc.21982
53期:5页:337-348
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Oncology
研究领域[WOS]Biochemistry & Molecular Biology ; Oncology
关键词[WOS]SPINDLE-ASSEMBLY CHECKPOINT ; GASTRIC-CANCER ; PROTEIN ; MITOSIS ; TARGETS ; ENTRY ; B1
英文摘要

In an earlier study, we cloned the p42.3 gene and showed that its expression was specific to tumors in a number of tumor cell lines and primary tumor tissues. However, the biological role and function of this gene remains largely unknown. In this study, p42.3 expression was found to be cell cycle-dependent at both the mRNA and protein levels in several human tumor cell lines. Typically, abundant expression was detected at G1 and M phases compared with S and G2 phases. Expression peaked at early G1 phase then decreased drastically at late G1, S, and G2. Furthermore, transfection of the p42.3 gene into NIH3T3 cells promoted malignant transformation, accompanied by accelerated mitotic progression and altered chromosome segregation. It was also observed that Cyclin B1 was upregulated and Cdc2-Tyr15 was downregulated following p42.3 overexpression in NIH3T3 cells. Combined, these results indicate that p42.3 as a cell cycle-regulated gene contributes to promoting cell cycle progression through disruption of mitotic regulation, and may play important roles in malignant transformation. (c) 2012 Wiley Periodicals, Inc.

语种英语
WOS记录号WOS:000333568700001
项目编号5102018 ; 30901724 ; 2006AA02A402
资助机构Beijing Natural Science Foundation ; National Natural Science Foundation ; National Bio-Tech 86-3
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55649
专题北京大学临床肿瘤学院_分子肿瘤学研究室
北京大学临床肿瘤学院_高技术实验室
作者单位Peking Univ, Canc Hosp & Inst, Mol Oncol Lab, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
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Mao, Linlin,Sun, Wei,Li, Wenmei,et al. Cell cycle-dependent expression of p42.3 promotes mitotic progression in malignant transformed cells[J]. MOLECULAR CARCINOGENESIS,2014,53(5):337-348.
APA Mao, Linlin.,Sun, Wei.,Li, Wenmei.,Cui, Jiantao.,Zhang, Jingyu.,...&Lu, Youyong.(2014).Cell cycle-dependent expression of p42.3 promotes mitotic progression in malignant transformed cells.MOLECULAR CARCINOGENESIS,53(5),337-348.
MLA Mao, Linlin,et al."Cell cycle-dependent expression of p42.3 promotes mitotic progression in malignant transformed cells".MOLECULAR CARCINOGENESIS 53.5(2014):337-348.
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