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学科主题: 临床医学
题名:
Cell cycle-dependent expression of p42.3 promotes mitotic progression in malignant transformed cells
作者: Mao, Linlin; Sun, Wei; Li, Wenmei; Cui, Jiantao; Zhang, Jingyu; Xing, Rui; Lu, Youyong
关键词: p42.3 ; cell transformation ; cell cycle ; early G1 ; mitotic progression
刊名: MOLECULAR CARCINOGENESIS
发表日期: 2014-05-01
DOI: 10.1002/mc.21982
卷: 53, 期:5, 页:337-348
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Oncology
研究领域[WOS]: Biochemistry & Molecular Biology ; Oncology
关键词[WOS]: SPINDLE-ASSEMBLY CHECKPOINT ; GASTRIC-CANCER ; PROTEIN ; MITOSIS ; TARGETS ; ENTRY ; B1
英文摘要:

In an earlier study, we cloned the p42.3 gene and showed that its expression was specific to tumors in a number of tumor cell lines and primary tumor tissues. However, the biological role and function of this gene remains largely unknown. In this study, p42.3 expression was found to be cell cycle-dependent at both the mRNA and protein levels in several human tumor cell lines. Typically, abundant expression was detected at G1 and M phases compared with S and G2 phases. Expression peaked at early G1 phase then decreased drastically at late G1, S, and G2. Furthermore, transfection of the p42.3 gene into NIH3T3 cells promoted malignant transformation, accompanied by accelerated mitotic progression and altered chromosome segregation. It was also observed that Cyclin B1 was upregulated and Cdc2-Tyr15 was downregulated following p42.3 overexpression in NIH3T3 cells. Combined, these results indicate that p42.3 as a cell cycle-regulated gene contributes to promoting cell cycle progression through disruption of mitotic regulation, and may play important roles in malignant transformation. (c) 2012 Wiley Periodicals, Inc.

语种: 英语
所属项目编号: 5102018 ; 30901724 ; 2006AA02A402
项目资助者: Beijing Natural Science Foundation ; National Natural Science Foundation ; National Bio-Tech 86-3
WOS记录号: WOS:000333568700001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55649
Appears in Collections:北京大学临床肿瘤学院_分子肿瘤学研究室_期刊论文

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作者单位: Peking Univ, Canc Hosp & Inst, Mol Oncol Lab, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China

Recommended Citation:
Mao, Linlin,Sun, Wei,Li, Wenmei,et al. Cell cycle-dependent expression of p42.3 promotes mitotic progression in malignant transformed cells[J]. MOLECULAR CARCINOGENESIS,2014,53(5):337-348.
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