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学科主题: 基础医学
题名:
Cardiotonic pills, a compound Chinese medicine, protects ischemia-reperfusion-induced microcirculatory disturbance and myocardial damage in rats
作者: Zhao, Na2; Liu, Yu-Ying2; Wang, Fang2; Hu, Bai-He2; Sun, Kai2; Chang, Xin2; Pan, Chun-Shui2; Fan, Jing-Yu2; Wei, Xiao-Hong2; Li, Xiang2; Wang, Chuan-She2; Guo, Zhi-Xin2; Han, Jing-Yan1,2
关键词: myocardial microcirculatory disturbances ; Salvia miltiorrhiza ; Panax notoginseng ; apoptosis-related proteins
刊名: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
发表日期: 2010-04-01
DOI: 10.1152/ajpheart.01186.2009
卷: 298, 期:4, 页:H1166-H1176
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems ; Physiology ; Peripheral Vascular Disease
研究领域[WOS]: Cardiovascular System & Cardiology ; Physiology
关键词[WOS]: NO-REFLOW PHENOMENON ; ISCHEMIA/REPERFUSION INJURY ; SALVIA-MILTIORRHIZA ; CARDIAC MYOCYTES ; OXIDATIVE STRESS ; KAPPA-B ; APOPTOSIS ; INFARCTION ; NECROSIS ; ADHESION
英文摘要:

Zhao N, Liu YY, Wang F, Hu BH, Sun K, Chang X, Pan CS, Fan JY, Wei XH, Li X, Wang CS, Guo ZX, Han JY. Cardiotonic pills, a compound Chinese medicine, protects ischemia-reperfusion-induced microcirculatory disturbance and myocardial damage in rats. Am J Physiol Heart Circ Physiol 298: H1166-H1176, 2010. First published January 29, 2010; doi: 10.1152/ajpheart.01186.2009.- Cardiotonic pills (CP) is a compound Chinese medicine widely used in China, as well as other countries, for the treatment of cardiovascular disease. However, limited data are available regarding the mechanism of action of CP on myocardial function during ischemia-reperfusion (I/R) injury. In this study, we examined the effect of CP on I/R-induced coronary microcirculatory disturbance and myocardial damage. Male Sprague-Dawley rats were subjected to left coronary anterior descending branch occlusion for 30 min followed by reperfusion with or without pretreatment with CP (0.1, 0.4, or 0.8 g/kg). Coronary blood flow, vascular diameter, velocity of red blood cells, and albumin leakage were evaluated in vivo after reperfusion. Neutrophil expression of CD18, malondialdehyde, inhibitor-kappa B alpha, myocardial infarction, endothelial expression of intercellular adhesion molecule 1, apoptosis-related proteins, and histological and ultrastructural evidence of myocardial damage were assessed after reperfusion. Pretreatment with CP (0.8 g/kg) significantly attenuated the I/R-induced myocardial microcirculatory disturbance, including decreased coronary blood flow and red blood cell velocity in arterioles, increased expression of CD18 on neutrophils and intercellular adhesion molecule 1 on endothelial cells, and albumin leakage from venules. In addition, the drug significantly ameliorated the I/R-induced myocardial damage and apoptosis indicated by increased malondialdehyde, infarct size, myocardial ultrastructural changes, terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling-positive myocardial cells, inhibitor-kappa B alpha degradation, and expression of Bcl-2, Bax, and caspase-3 in myocardial tissues. The results provide evidence for the potential role of CP in preventing microcirculatory disturbance and myocardial damage following I/R injury.

语种: 英语
所属项目编号: 2006DFA32340
项目资助者: Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号: WOS:000275768600007
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55653
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Zhao, Na,Liu, Yu-Ying,Wang, Fang,et al. Cardiotonic pills, a compound Chinese medicine, protects ischemia-reperfusion-induced microcirculatory disturbance and myocardial damage in rats[J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY,2010,298(4):H1166-H1176.
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