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Cardiotonic pills, a compound Chinese medicine, protects ischemia-reperfusion-induced microcirculatory disturbance and myocardial damage in rats
Zhao, Na2; Liu, Yu-Ying2; Wang, Fang2; Hu, Bai-He2; Sun, Kai2; Chang, Xin2; Pan, Chun-Shui2; Fan, Jing-Yu2; Wei, Xiao-Hong2; Li, Xiang2
Source PublicationAMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
2010-04-01
Volume298Issue:4Pages:H1166-H1176
Indexed BySCI
Abstract

Zhao N, Liu YY, Wang F, Hu BH, Sun K, Chang X, Pan CS, Fan JY, Wei XH, Li X, Wang CS, Guo ZX, Han JY. Cardiotonic pills, a compound Chinese medicine, protects ischemia-reperfusion-induced microcirculatory disturbance and myocardial damage in rats. Am J Physiol Heart Circ Physiol 298: H1166-H1176, 2010. First published January 29, 2010; doi: 10.1152/ajpheart.01186.2009.- Cardiotonic pills (CP) is a compound Chinese medicine widely used in China, as well as other countries, for the treatment of cardiovascular disease. However, limited data are available regarding the mechanism of action of CP on myocardial function during ischemia-reperfusion (I/R) injury. In this study, we examined the effect of CP on I/R-induced coronary microcirculatory disturbance and myocardial damage. Male Sprague-Dawley rats were subjected to left coronary anterior descending branch occlusion for 30 min followed by reperfusion with or without pretreatment with CP (0.1, 0.4, or 0.8 g/kg). Coronary blood flow, vascular diameter, velocity of red blood cells, and albumin leakage were evaluated in vivo after reperfusion. Neutrophil expression of CD18, malondialdehyde, inhibitor-kappa B alpha, myocardial infarction, endothelial expression of intercellular adhesion molecule 1, apoptosis-related proteins, and histological and ultrastructural evidence of myocardial damage were assessed after reperfusion. Pretreatment with CP (0.8 g/kg) significantly attenuated the I/R-induced myocardial microcirculatory disturbance, including decreased coronary blood flow and red blood cell velocity in arterioles, increased expression of CD18 on neutrophils and intercellular adhesion molecule 1 on endothelial cells, and albumin leakage from venules. In addition, the drug significantly ameliorated the I/R-induced myocardial damage and apoptosis indicated by increased malondialdehyde, infarct size, myocardial ultrastructural changes, terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling-positive myocardial cells, inhibitor-kappa B alpha degradation, and expression of Bcl-2, Bax, and caspase-3 in myocardial tissues. The results provide evidence for the potential role of CP in preventing microcirculatory disturbance and myocardial damage following I/R injury.

KeywordMyocardial Microcirculatory Disturbances Salvia Miltiorrhiza Panax Notoginseng Apoptosis-related Proteins
Subject Area基础医学
SubtypeArticle
DOI10.1152/ajpheart.01186.2009
WOS HeadingsScience & Technology
Language英语
Funding OrganizationMinistry of Science and Technology of the People&prime ; s Republic of China
WOS Research AreaCardiovascular System & Cardiology ; Physiology
WOS SubjectCardiac & Cardiovascular Systems ; Physiology ; Peripheral Vascular Disease
WOS KeywordNO-REFLOW PHENOMENON ; ISCHEMIA/REPERFUSION INJURY ; SALVIA-MILTIORRHIZA ; CARDIAC MYOCYTES ; OXIDATIVE STRESS ; KAPPA-B ; APOPTOSIS ; INFARCTION ; NECROSIS ; ADHESION
WOS IDWOS:000275768600007
Citation statistics
Cited Times:50[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.bjmu.edu.cn/handle/400002259/55653
Collection北京大学基础医学院
北京大学医学部管理机构_医学部
Affiliation1.Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100191, Peoples R China
First Author AffilicationPeking University School of Basic Medical Sciences
Recommended Citation
GB/T 7714
Zhao, Na,Liu, Yu-Ying,Wang, Fang,et al. Cardiotonic pills, a compound Chinese medicine, protects ischemia-reperfusion-induced microcirculatory disturbance and myocardial damage in rats[J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY,2010,298(4):H1166-H1176.
APA Zhao, Na.,Liu, Yu-Ying.,Wang, Fang.,Hu, Bai-He.,Sun, Kai.,...&Han, Jing-Yan.(2010).Cardiotonic pills, a compound Chinese medicine, protects ischemia-reperfusion-induced microcirculatory disturbance and myocardial damage in rats.AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY,298(4),H1166-H1176.
MLA Zhao, Na,et al."Cardiotonic pills, a compound Chinese medicine, protects ischemia-reperfusion-induced microcirculatory disturbance and myocardial damage in rats".AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 298.4(2010):H1166-H1176.
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