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学科主题: 药学
题名:
Design and synthesis of novel multivalent mannosides targeting the mannose receptor
作者: Yin, Zhao-Jun; Li, Qing; Meng, Xiang-Bao; Li, Zhong-Jun
关键词: multivalent ; mannoside ; mannose receptor
刊名: CARBOHYDRATE RESEARCH
发表日期: 2007-12-28
DOI: 10.1016/j.carres.2007.08.017
卷: 342, 期:18, 页:2729-2734
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Chemistry, Applied ; Chemistry, Organic
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]: CARBOHYDRATE-RECOGNITION DOMAINS ; LIGAND-BINDING ; GLYCOSYLATION ; HOMEOSTASIS ; CELLS
英文摘要:

According to the characteristics of C-type lectin-like domains in the mannose receptor (MR), a novel design of multivalent mannosides targeting the MR was accomplished. Beginning with a divalent mannoside as the sugar unit, a series of multivalent mannosides with variations in both valence and space were synthesized in a convergent approach. The synthetic multivalent mannosides are to be explored to study MR-sugar binding events. (C) 2007 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000251872000004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55655
Appears in Collections:北京大学药学院_天然药物与仿生药物国家重点实验室_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Dept Biol Chem, Sch Pharmaceut Sci,State Key Lab Nat & Biomimet D, Beijing 100083, Peoples R China

Recommended Citation:
Yin, Zhao-Jun,Li, Qing,Meng, Xiang-Bao,et al. Design and synthesis of novel multivalent mannosides targeting the mannose receptor[J]. CARBOHYDRATE RESEARCH,2007,342(18):2729-2734.
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