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学科主题基础医学
Argatroban for Preventing Occlusion and Restenosis after Extracranial Artery Stenting
Zhou, Lulu1; Liu, Dezhi2; Li, Yun1,2; Zhu, Wusheng1,2; Sun, Wen1,2; Li, Yongkun1,2; Xiong, Yunyun1,2; Chen, Zhaoyao3; Wang, Qizhang1,4; Cai, Qiankun1,2; Wang, Zhaolu1,2; Wang, Xiaomeng1,2; Sun, Wenshan1,2; Ge, Liang1,2; Ma, Minmin1,2; Li, Min1,2; Li, Hua1,2; Fan, Xinying1,2; Yin, Qin1,2; Xu, Gelin1,2; Liu, George5; Fan, Xiaobing1,2; Liu, Xinfeng1,2
关键词Argatroban Restenosis Thrombin Extracranial Artery Stenting
刊名EUROPEAN NEUROLOGY
2014
DOI10.1159/000357866
71期:5-6页:319-325
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Neurosciences
资助者Natural Science Foundation of China (NSFC) ; Natural Science Foundation of China (NSFC)
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]RANDOMIZED CONTROLLED-TRIAL ; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY ; INTRACRANIAL ATHEROMATOUS DISEASE ; CORONARY BALLOON ANGIOPLASTY ; US MULTICENTER EXPERIENCE ; NEOINTIMAL PROLIFERATION ; ENDARTERECTOMY ; THROMBIN ; STENOSIS ; INJURY
英文摘要

Background/Aims: Restenosis following extracranial artery stenting is a limitation that affects long-term outcomes. Effective and satisfying pharmacological strategies in preventing restenosis have not been established. This study aimed to evaluate whether argatroban, a direct thrombin inhibitor, could reduce the risk of in-stent restenosis after extracranial artery stenting. Methods: One hundred and fourteen patients hospitalized between August 2010 and August 2011 were enrolled. Patients were randomly assigned to argatroban (n = 58) and blank control groups (n = 56). The patients in the argatroban arm were treated with 10 mg of intravenous argatroban twice daily 2 days before and 3 days after the stenting procedures. Patients were followed for 12 months after the procedure. During follow-up, restenosis and target revascularization were analyzed. Recurrent cerebrovascular and cardiovascular events and deaths were also compared between the groups. Results: One patient in the stenting group withdrew immediately after the procedure due to unsuccessful stenting. Restenosis occurred in 4 patients (7.4%) in the argatroban group and in 11 patients (21.6%) in the control group during the 6- to 9-month angiographic follow-up period (p = 0.032). Nine months after the procedures, argatroban-treated patients had a trend towards a lower incidence of target revascularization compared with the controls (5.4 vs. 13.7%, p = 0.188). No major bleeding events or other adverse events occurred in the argatroban group. Conclusion: This pilot clinical trial is the first that uses argatroban to prevent restenosis in ischemic cerebrovascular disease, and suggests that intravenous administration of argatroban is effective and safe in preventing restenosis after extracranial artery stenting. Larger randomized controlled clinical trials are warranted. (C) 2014 S. Karger AG, Basel

语种英语
所属项目编号30870847 ; 81000501 ; 30870848
资助者Natural Science Foundation of China (NSFC) ; Natural Science Foundation of China (NSFC)
WOS记录号WOS:000336425800018
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55656
专题基础医学院_心血管所
作者单位1.Southern Med Univ, Jinling Hosp, Dept Neurol, Nanjing 210002, Jiangsu, Peoples R China
2.Nanjing Univ, Jinling Hosp, Sch Med, Nanjing 210008, Jiangsu, Peoples R China
3.Nanjing Univ, Affiliated Hosp, TCM, Nanjing 210008, Jiangsu, Peoples R China
4.Guangzhou Med Univ, Shenzhen Shajing Peoples Hosp, Guangzhou, Guangdong, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Inst Cardiovasc Sci, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Lulu,Liu, Dezhi,Li, Yun,et al. Argatroban for Preventing Occlusion and Restenosis after Extracranial Artery Stenting[J]. EUROPEAN NEUROLOGY,2014,71(5-6):319-325.
APA Zhou, Lulu.,Liu, Dezhi.,Li, Yun.,Zhu, Wusheng.,Sun, Wen.,...&Liu, Xinfeng.(2014).Argatroban for Preventing Occlusion and Restenosis after Extracranial Artery Stenting.EUROPEAN NEUROLOGY,71(5-6),319-325.
MLA Zhou, Lulu,et al."Argatroban for Preventing Occlusion and Restenosis after Extracranial Artery Stenting".EUROPEAN NEUROLOGY 71.5-6(2014):319-325.
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