IR@PKUHSC  > 北京大学基础医学院  > 药理学系
学科主题基础医学
Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction
Zhou, Hong1,6; Nakamura, Takeshi3,4,5; Matsumoto, Nagisa2; Hisatsune, Chihiro1; Mizutani, Akihiro2; Iesaki, Takafumi; Daida, Hiroyuki; Mikoshiba, Katsuhiko1,2,3,5
关键词Thoracic Aorta Vascular Smooth Muscle Cells 2-aminoethyl Diphenylborinate Phenylephrine
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2008-04-25
DOI10.1016/j.bbrc.2007.12.194
369期:1页:213-219
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR ; SMOOTH-MUSCLE ; FUNCTIONAL EXPRESSION ; INTRACELLULAR CA2+ ; CA-2+ RELEASE ; CELLS ; PROLIFERATION ; MECHANISMS ; CHANNELS
英文摘要

Inositol 1,4,5-trisphosphate receptor (IP3R) plays a crucial role in generating Ca2+ signaling and three subtypes of IP3R have been identified. In spite of a high degree of similarity among these subtypes, their effects on spatio-temporal Ca2+ patterns are specific and diverse; therefore the physiological significance of the differential expression levels of IP3R subtypes in various tissues remains unknown. Here, we examined the relative contribution of the specific subtype of IP(3)Rs to the agonist-induced Ca2+ signaling and contraction in IP3R-deficient vascular smooth muscle cells and found that IP(3)R1 deficient cells exclusively showed less sensitivity to the agonist, compared to those from the other genotypes. We also found that IP(3)R1 dominantly expressed in vascular aortae on a consistent basis, and that phenylephrine (PE)-induced aortic muscle contraction was reduced specifically in IP(3)R1-deficient aortae. Taken together, we concluded that IP(3)R1 plays a predominant role in the function of the vascular smooth muscle in vivo. (c) 2008 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000254478000029
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55662
专题北京大学基础医学院_药理学系
作者单位1.RIKEN, Brain Sci Inst, Dev Neurobiol Lab, Wako, Saitama 3510198, Japan
2.Univ Tokyo, Inst Med Sci, Div Mol Neurobiol, Minato Ku, Tokyo 1088639, Japan
3.Japan Sci & Technol Corp, ICORP, Calcium Oscillat Project, Minato Ku, Tokyo 1080071, Japan
4.Juntendo Univ, Sch Med, Dept Physiol, Bunkyo Ku, Tokyo 1138421, Japan
5.Juntendo Univ, Sch Med, Dept Cardiol, Bunkyo Ku, Tokyo 1138421, Japan
6.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Hong,Nakamura, Takeshi,Matsumoto, Nagisa,et al. Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2008,369(1):213-219.
APA Zhou, Hong.,Nakamura, Takeshi.,Matsumoto, Nagisa.,Hisatsune, Chihiro.,Mizutani, Akihiro.,...&Mikoshiba, Katsuhiko.(2008).Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,369(1),213-219.
MLA Zhou, Hong,et al."Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 369.1(2008):213-219.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Predominant role of (429KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhou, Hong]的文章
[Nakamura, Takeshi]的文章
[Matsumoto, Nagisa]的文章
百度学术
百度学术中相似的文章
[Zhou, Hong]的文章
[Nakamura, Takeshi]的文章
[Matsumoto, Nagisa]的文章
必应学术
必应学术中相似的文章
[Zhou, Hong]的文章
[Nakamura, Takeshi]的文章
[Matsumoto, Nagisa]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。