IR@PKUHSC  > 北京大学基础医学院  > 药理学系
学科主题基础医学
Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction
Zhou, Hong1,6; Nakamura, Takeshi3,4,5; Matsumoto, Nagisa2; Hisatsune, Chihiro1; Mizutani, Akihiro2; Iesaki, Takafumi; Daida, Hiroyuki; Mikoshiba, Katsuhiko1,2,3,5
关键词Thoracic Aorta Vascular Smooth Muscle Cells 2-aminoethyl Diphenylborinate Phenylephrine
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2008-04-25
DOI10.1016/j.bbrc.2007.12.194
369期:1页:213-219
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR ; SMOOTH-MUSCLE ; FUNCTIONAL EXPRESSION ; INTRACELLULAR CA2+ ; CA-2+ RELEASE ; CELLS ; PROLIFERATION ; MECHANISMS ; CHANNELS
英文摘要

Inositol 1,4,5-trisphosphate receptor (IP3R) plays a crucial role in generating Ca2+ signaling and three subtypes of IP3R have been identified. In spite of a high degree of similarity among these subtypes, their effects on spatio-temporal Ca2+ patterns are specific and diverse; therefore the physiological significance of the differential expression levels of IP3R subtypes in various tissues remains unknown. Here, we examined the relative contribution of the specific subtype of IP(3)Rs to the agonist-induced Ca2+ signaling and contraction in IP3R-deficient vascular smooth muscle cells and found that IP(3)R1 deficient cells exclusively showed less sensitivity to the agonist, compared to those from the other genotypes. We also found that IP(3)R1 dominantly expressed in vascular aortae on a consistent basis, and that phenylephrine (PE)-induced aortic muscle contraction was reduced specifically in IP(3)R1-deficient aortae. Taken together, we concluded that IP(3)R1 plays a predominant role in the function of the vascular smooth muscle in vivo. (c) 2008 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000254478000029
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55662
Collection北京大学基础医学院_药理学系
作者单位1.RIKEN, Brain Sci Inst, Dev Neurobiol Lab, Wako, Saitama 3510198, Japan
2.Univ Tokyo, Inst Med Sci, Div Mol Neurobiol, Minato Ku, Tokyo 1088639, Japan
3.Japan Sci & Technol Corp, ICORP, Calcium Oscillat Project, Minato Ku, Tokyo 1080071, Japan
4.Juntendo Univ, Sch Med, Dept Physiol, Bunkyo Ku, Tokyo 1138421, Japan
5.Juntendo Univ, Sch Med, Dept Cardiol, Bunkyo Ku, Tokyo 1138421, Japan
6.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Hong,Nakamura, Takeshi,Matsumoto, Nagisa,et al. Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2008,369(1):213-219.
APA Zhou, Hong.,Nakamura, Takeshi.,Matsumoto, Nagisa.,Hisatsune, Chihiro.,Mizutani, Akihiro.,...&Mikoshiba, Katsuhiko.(2008).Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,369(1),213-219.
MLA Zhou, Hong,et al."Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 369.1(2008):213-219.
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