|Plasma Osteoprotegerin Levels and Long-Term Prognosis in Patients With Intermediate Coronary Artery Lesions|
|Yang, Qingmiao1,2; Lu, Shuzheng1; Chen, Yundai3; Song, Xiantao1; Jin, Zening1; Yuan, Fei1; Li, Hong1; Zhou, Yujie1; Chen, Fang1; Huo, Yong4|
|WOS标题词||Science & Technology|
|类目[WOS]||Cardiac & Cardiovascular Systems|
|研究领域[WOS]||Cardiovascular System & Cardiology|
|关键词[WOS]||CARDIOVASCULAR-DISEASE ; MYOCARDIAL-INFARCTION ; EXPRESSION ; CELLS ; BONE|
Background: Osteoprotegerin (OPG) is a member of the tumor necrosis factor superfamily and plays an important regulatory role in the skeletal, immune, and vascular systems. Intermediate coronary artery lesions that have a diameter stenosis of approximately 20%-70% might cause serious consequences. However, the prognostic value of plasma OPG levels in patients with intermediate coronary artery lesions has been less reported.
Hypothesis: We hypothesized that OPG is a predictive marker of prognosis of intermediate coronary artery lesions.
Methods: A prospective study was performed on 890 patients with intermediate (20%-70%) coronary lesions. The median age was 62 years (25th and 75th percentiles, 55 and 70 years, respectively) and 67.2% were male. Fasting blood was sampled at baseline. The primary clinical endpoint was a composite of readmission due to angina pectoris, nonfatal myocardial infarction, revascularization, and cardiovascular death.
Results: During a median follow-up of 24 months, events occurred in 11.1% of the patients. Of these patients, 7.9% were readmitted for angina pectoris, 1.5% received revascularization, 0.7% suffered nonfatal myocardial infarction, and 1.0% died. The plasma levels of OPG (median, 5304.7 pg/mL vs 2993.4 pg/mL, P < 0.001) and high-sensitivity C-reactive protein (median, 4.8 mg/L vs 2.6 mg/L, P < 0.001) were higher in patients with events than those without events. After adjusting for traditional risk factors such as age, gender, smoking, hypertension, diabetes, dyslipidemia, high-density lipoprotein cholesterol, high-sensitivity C-reactive protein, percent area stenosis, and drug administration, a multivariate Cox proportional hazard analysis showed that higher OPG levels were an independent predictive factor of the composite clinical endpoint (hazard ratio: 2.49, 95% confidence interval: 1.26-4.89, fourth quartile vs first quartile).
Conclusions: The higher level of OPG is an independent predictive factor of prognosis in patients with intermediate coronary lesions.
|资助机构||Beijing Municipal Science and Technology Committee|
|作者单位||1.Capital Med Univ, Dept Cardiol, Beijing Anzhen Hosp, Beijing 100029, Peoples R China|
2.Capital Med Univ, Dept Cardiol, Beijing Tongren Hosp, Beijing 100029, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, Beijing, Peoples R China
4.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100871, Peoples R China
|Yang, Qingmiao,Lu, Shuzheng,Chen, Yundai,et al. Plasma Osteoprotegerin Levels and Long-Term Prognosis in Patients With Intermediate Coronary Artery Lesions[J]. CLINICAL CARDIOLOGY,2011,34(7):447-453.|
|APA||Yang, Qingmiao.,Lu, Shuzheng.,Chen, Yundai.,Song, Xiantao.,Jin, Zening.,...&Huo, Yong.(2011).Plasma Osteoprotegerin Levels and Long-Term Prognosis in Patients With Intermediate Coronary Artery Lesions.CLINICAL CARDIOLOGY,34(7),447-453.|
|MLA||Yang, Qingmiao,et al."Plasma Osteoprotegerin Levels and Long-Term Prognosis in Patients With Intermediate Coronary Artery Lesions".CLINICAL CARDIOLOGY 34.7(2011):447-453.|