IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Correlation of Plasma Catestatin Level and the Prognosis of Patients with Acute Myocardial Infarction
Zhu, Dan; Xie, Hong; Wang, Xinyu; Yu, Haiyi; Gao, Wei
刊名PLOS ONE
2015-04-07
DOI10.1371/journal.pone.0122993
10期:4
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者National Natural Science Foundation of China ; Ph.D. Programs Foundation of the Ministry of Education of China ; International cooperation projects of the Ministry of Science and Technology ; National Natural Science Foundation of China ; Ph.D. Programs Foundation of the Ministry of Education of China ; International cooperation projects of the Ministry of Science and Technology
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]INHIBITORY PEPTIDE CATESTATIN ; CHROMOGRANIN-A FRAGMENT ; CATECHOLAMINE RELEASE ; HEART-FAILURE ; IN-VIVO ; ACTIVATION ; MECHANISM ; HUMANS ; ACTS ; TERM
英文摘要

Catestatin is a peptide which is a potent inhibitor of catecholamine secretion and played essential functions in the cardiovascular system. Previous research found that dramatic changes of catestatin were associated with hemodynamics in acute myocardial infarction (AMI) during the first week after the AMI symptoms onset, but whether catestatin is also involved in the pathophysiological progression after AMI and then a predictor for outcomes is not clear. The aim of this study is to determine the correlation of plasma catestatin levels at different time points and the prognosis of AMI. 100 participants recruited were all patients with AMI, all of who received successful primary percutaneous coronary intervention (PCI) within 12h from the AMI symptom onset in our center; the concentrations of plasma catestatin were evaluated from blood samples of those 100 participants. Subsequent 65 months′ follow-up was performed after discharging to evaluate cardiac adverse events and the association between catestatin levels and prognosis of AMI was examined. We confirmed the dramatic change of catestatin concentrations in the first week of AMI, and the levels of catestatin on D3 were much higher in adverse events group than those in non-adverse events group (p<0.0001), but the ratio of D7/D3 was significantly lower. In addition, the Kaplan-Meier analysis showed that the groups in which the levels on D3 were higher (p<0.0001) and the ratios of D7/D3 were lower (p<0.0001), patients trended to be more susceptive to adverse events after AMI. Furthermore, according to the analysis, we surmised catestatin level on D3 as an appropriate predictor for outcomes in patients with AMI with good specificity as well as sensitivity. All of the evidence confirmed that catestatin plays an important role in the progress of AMI, and may act as a promising target for prognostic prediction.

语种英语
所属项目编号81200167 ; 20120001120131 ; 2013DFG32940
资助者National Natural Science Foundation of China ; Ph.D. Programs Foundation of the Ministry of Education of China ; International cooperation projects of the Ministry of Science and Technology ; National Natural Science Foundation of China ; Ph.D. Programs Foundation of the Ministry of Education of China ; International cooperation projects of the Ministry of Science and Technology
WOS记录号WOS:000352477800191
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55669
Collection北京大学第三临床医学院
作者单位Peking Univ, Hosp 3, Dept Cardiol,Minist Hlth, Key Lab Cardiovasc Mol Biol & Regulatory Peptided, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Dan,Xie, Hong,Wang, Xinyu,et al. Correlation of Plasma Catestatin Level and the Prognosis of Patients with Acute Myocardial Infarction[J]. PLOS ONE,2015,10(4).
APA Zhu, Dan,Xie, Hong,Wang, Xinyu,Yu, Haiyi,&Gao, Wei.(2015).Correlation of Plasma Catestatin Level and the Prognosis of Patients with Acute Myocardial Infarction.PLOS ONE,10(4).
MLA Zhu, Dan,et al."Correlation of Plasma Catestatin Level and the Prognosis of Patients with Acute Myocardial Infarction".PLOS ONE 10.4(2015).
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