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学科主题: 临床医学
题名:
E112D polymorphism in the prolylcarboxypeptidase gene is associated with blood pressure response to benazepril in Chinese hypertensive patients
作者: Zhang Yan2; Hong Xiu-mei1; Xing Hou-xun1; Li Jian-ping2; Huo Yong2; Xu Xi-ping1
关键词: benazepril ; prolylcarboxypeptidase ; polymorphism ; hypertension
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2009-10-20
DOI: 10.3760/cma.j.issn.0366-6999.2009.20.012
卷: 122, 期:20, 页:2461-2465
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: ANGIOTENSINOGEN GENE ; PLASMA PREKALLIKREIN ; ENZYME ; RECEPTOR ; ACTIVATION ; THERAPY ; CELLS ; RISK
英文摘要:

Background Marked interindividual variation exists in blood pressure response to benazepril, which is considered to have genetic basis. Our objectives were to evaluate whether the E112D polymorphism in the prolylcarboxypeptidase (PRCP) gene has impact on blood pressure response to benazepril.

Methods Hypertensive patients from Huoqiu County and Yuexi County of Anhui Province received daily treatment with an oral dosage of 10 mg benazepril for 15 days. Genotypes of the E112D polymorphism in the PRCP gene were determined by TaqMan SNP genotyping assay. Multivariate linear and Logistic regressions using generalized estimating equation model were performed in a total of 1092 patients to evaluate the association of PRCP genotypes and blood pressure response to benazepril.

Results Patients carrying ED or DD genotype had a less systolic blood pressure reduction (adjusted beta= -3.7+/-1.1, P <0.001), a less diastolic blood pressure reduction (adjusted beta= -3.1+/-0.8, P <0.001) and a lower percentage of reaching target blood pressure defined as SBP lower than 140 mmHg and DBP lower than 90 mmHg (adjusted OR=0.6, P=0.005) than those patients carrying EE genotype. In addition, the results from stratified analysis by county (Huoqiu or Yuexi) were similar to those observed in the pooled population.

Conclusions Our data suggest that the E112D polymorphism in the PRCP gene may be a useful genetic marker to predict the anti hypertensive effect of short-term benazepril treatment in hypertensive patients of Anhui Province, China. Chin Med J 2009;122(20):2461-2465

语种: 英语
WOS记录号: WOS:000271367000012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55670
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Anhui Med Univ, Inst Biomed, Hefei 230032, Anhui, Peoples R China
2.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100034, Peoples R China

Recommended Citation:
Zhang Yan,Hong Xiu-mei,Xing Hou-xun,et al. E112D polymorphism in the prolylcarboxypeptidase gene is associated with blood pressure response to benazepril in Chinese hypertensive patients[J]. CHINESE MEDICAL JOURNAL,2009,122(20):2461-2465.
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