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学科主题: 临床医学
题名:
Characteristics of 292 testis-specific genes in human
作者: Tang, Aifa; Yu, Zhendong; Gui, Yaoting; Zhu, Hui; Zhang, Libin; Zhang, Hanrong; Cai, Zhiming
关键词: spermatogenesis ; testis-specific gene ; gene ontology
刊名: BIOLOGICAL & PHARMACEUTICAL BULLETIN
发表日期: 2007-05-01
卷: 30, 期:5, 页:865-872
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: TRANSCRIPTIONAL REGULATION ; SPERMATOGENIC CELLS ; TRANSGENIC MICE ; IDENTIFICATION ; EXPRESSION ; PROTEIN
英文摘要:

To explore their genomic and functional characteristics, 292 human testis-specific genes were obtained from a UniGene library and a full-scale analysis was made. Various bioinformatics tools were applied to analyze the gene ontology and chromosome location, and the expression profiles of eight selected candidates from the 292 genes were analyzed using RT-PCR for 12 adult human tissues. The results showed that of the total 292 genes, 153 were known (114 assigned genes and 39 named genes), and 139 were unknown. Of the 114 assigned genes, 63 were labeled to molecular function, 28 to cellular component, 23 to biological process. All 292 genes are distributed on human chromosomes at different gene density, lower gene density appears on chromosomes 21 (11=0.22), X (11=033), 14 (11=039), 10 (11=0.61), 8 (11=0.63), and 18 (R=0.67) and higher density on chromosomes 19 (R=3.65), 20 (R= 1.83), 16 (R= 1.74), and 17 (R= 1.64). The expression profile of the eight selected genes in the 12 human tissues showed that five candidate genes: Hs.443729, Hs.115366, Hs.558087, Hs.534501, and Hs.132104 were expressed exclusively in human testis; Hs.132310, Hs.443299 were expressed highly in testis and also expressed weakly in human heart; Hs.160370 was expressed in human testis, ovary, uterus, and not expressed in other tissues. Our study can be a basis for characterization of the function of human testis-specific genes during male mammalian spermatogenesis.

语种: 英语
WOS记录号: WOS:000247078300004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55672
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: Peking Univ, Shenzhen Hosp, Med Ctr PKU HKUST, Shenzhen Key Lab Male Reprod & Genet, Shenzhen 518036, Peoples R China

Recommended Citation:
Tang, Aifa,Yu, Zhendong,Gui, Yaoting,et al. Characteristics of 292 testis-specific genes in human[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2007,30(5):865-872.
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