IR@PKUHSC  > 北京大学深圳医院
学科主题临床医学
Characteristics of 292 testis-specific genes in human
Tang, Aifa; Yu, Zhendong; Gui, Yaoting; Zhu, Hui; Zhang, Libin; Zhang, Hanrong; Cai, Zhiming
关键词Spermatogenesis Testis-specific Gene Gene Ontology
刊名BIOLOGICAL & PHARMACEUTICAL BULLETIN
2007-05-01
30期:5页:865-872
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]TRANSCRIPTIONAL REGULATION ; SPERMATOGENIC CELLS ; TRANSGENIC MICE ; IDENTIFICATION ; EXPRESSION ; PROTEIN
英文摘要

To explore their genomic and functional characteristics, 292 human testis-specific genes were obtained from a UniGene library and a full-scale analysis was made. Various bioinformatics tools were applied to analyze the gene ontology and chromosome location, and the expression profiles of eight selected candidates from the 292 genes were analyzed using RT-PCR for 12 adult human tissues. The results showed that of the total 292 genes, 153 were known (114 assigned genes and 39 named genes), and 139 were unknown. Of the 114 assigned genes, 63 were labeled to molecular function, 28 to cellular component, 23 to biological process. All 292 genes are distributed on human chromosomes at different gene density, lower gene density appears on chromosomes 21 (11=0.22), X (11=033), 14 (11=039), 10 (11=0.61), 8 (11=0.63), and 18 (R=0.67) and higher density on chromosomes 19 (R=3.65), 20 (R= 1.83), 16 (R= 1.74), and 17 (R= 1.64). The expression profile of the eight selected genes in the 12 human tissues showed that five candidate genes: Hs.443729, Hs.115366, Hs.558087, Hs.534501, and Hs.132104 were expressed exclusively in human testis; Hs.132310, Hs.443299 were expressed highly in testis and also expressed weakly in human heart; Hs.160370 was expressed in human testis, ovary, uterus, and not expressed in other tissues. Our study can be a basis for characterization of the function of human testis-specific genes during male mammalian spermatogenesis.

语种英语
WOS记录号WOS:000247078300004
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55672
专题北京大学深圳医院
作者单位Peking Univ, Shenzhen Hosp, Med Ctr PKU HKUST, Shenzhen Key Lab Male Reprod & Genet, Shenzhen 518036, Peoples R China
推荐引用方式
GB/T 7714
Tang, Aifa,Yu, Zhendong,Gui, Yaoting,et al. Characteristics of 292 testis-specific genes in human[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2007,30(5):865-872.
APA Tang, Aifa.,Yu, Zhendong.,Gui, Yaoting.,Zhu, Hui.,Zhang, Libin.,...&Cai, Zhiming.(2007).Characteristics of 292 testis-specific genes in human.BIOLOGICAL & PHARMACEUTICAL BULLETIN,30(5),865-872.
MLA Tang, Aifa,et al."Characteristics of 292 testis-specific genes in human".BIOLOGICAL & PHARMACEUTICAL BULLETIN 30.5(2007):865-872.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Tang, Aifa]的文章
[Yu, Zhendong]的文章
[Gui, Yaoting]的文章
百度学术
百度学术中相似的文章
[Tang, Aifa]的文章
[Yu, Zhendong]的文章
[Gui, Yaoting]的文章
必应学术
必应学术中相似的文章
[Tang, Aifa]的文章
[Yu, Zhendong]的文章
[Gui, Yaoting]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。