IR@PKUHSC  > 北京大学第三临床医学院  > 眼科
学科主题临床医学
Effect of Supplemental Lutein and Zeaxanthin on Serum, Macular Pigmentation, and Visual Performance in Patients with Early Age-Related Macular Degeneration
Huang, Yang-Mu1; Dou, Hong-Liang2; Huang, Fei-Fei1; Xu, Xian-Rong1; Zou, Zhi-Yong1; Lin, Xiao-Ming1
刊名BIOMED RESEARCH INTERNATIONAL
2015
DOI10.1155/2015/564738
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]OPTICAL-DENSITY ; CONTROLLED-TRIAL ; EYE DISEASE ; ACUITY ; CAROTENOIDS
英文摘要

Purpose. To compare the 2-year effect of multiple doses of lutein/zeaxanthin on serum, macular pigmentation, and visual performance on patients with early age-related macular degeneration (AMD). Methods. In this randomized, double-blinded, and placebo-controlled trial, 112 early AMD patients randomly received either 10 mg lutein, 20 mg lutein, a combination of lutein (10 mg) and zeaxanthin (10 mg), or placebo daily for 2 years. Serum concentration of lutein/zeaxanthin, macular pigment optical density (MPOD), visual functions including best-spectacle corrected visual acuity (BCVA), contrast sensitivity (CS), flash recovery time (FRT), and vision-related quality of life (VFQ25) was quantified. Results. Serum lutein concentration and MPOD significantly increased in all the active treatment groups. Supplementation with 20 mg lutein was the most effective in increasing MPOD and CS at 3 cycles/degree for the first 48 weeks. However, they both significantly increased to the same peak value following supplementation with either 10 mg or 20 mg lutein during the intervention. No statistical changes of BCVA or FRT were observed during the trial. Conclusions. Long-term lutein supplementation could increase serum lutein concentration, MPOD, and visual sensitivities of early AMD patients. 10 mg lutein daily might be an advisable long-term dosage for early AMD treatment.

语种英语
所属项目编号81273063
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000351375600001
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55674
专题北京大学第三临床医学院_眼科
作者单位1.Peking Univ, Hlth Sci Ctr, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Ctr Eye, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Huang, Yang-Mu,Dou, Hong-Liang,Huang, Fei-Fei,et al. Effect of Supplemental Lutein and Zeaxanthin on Serum, Macular Pigmentation, and Visual Performance in Patients with Early Age-Related Macular Degeneration[J]. BIOMED RESEARCH INTERNATIONAL,2015.
APA Huang, Yang-Mu,Dou, Hong-Liang,Huang, Fei-Fei,Xu, Xian-Rong,Zou, Zhi-Yong,&Lin, Xiao-Ming.(2015).Effect of Supplemental Lutein and Zeaxanthin on Serum, Macular Pigmentation, and Visual Performance in Patients with Early Age-Related Macular Degeneration.BIOMED RESEARCH INTERNATIONAL.
MLA Huang, Yang-Mu,et al."Effect of Supplemental Lutein and Zeaxanthin on Serum, Macular Pigmentation, and Visual Performance in Patients with Early Age-Related Macular Degeneration".BIOMED RESEARCH INTERNATIONAL (2015).
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