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学科主题: 临床医学
题名:
Effect of Supplemental Lutein and Zeaxanthin on Serum, Macular Pigmentation, and Visual Performance in Patients with Early Age-Related Macular Degeneration
作者: Huang, Yang-Mu1; Dou, Hong-Liang2; Huang, Fei-Fei1; Xu, Xian-Rong1; Zou, Zhi-Yong1; Lin, Xiao-Ming1
刊名: BIOMED RESEARCH INTERNATIONAL
发表日期: 2015
DOI: 10.1155/2015/564738
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]: Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]: OPTICAL-DENSITY ; CONTROLLED-TRIAL ; EYE DISEASE ; ACUITY ; CAROTENOIDS
英文摘要:

Purpose. To compare the 2-year effect of multiple doses of lutein/zeaxanthin on serum, macular pigmentation, and visual performance on patients with early age-related macular degeneration (AMD). Methods. In this randomized, double-blinded, and placebo-controlled trial, 112 early AMD patients randomly received either 10 mg lutein, 20 mg lutein, a combination of lutein (10 mg) and zeaxanthin (10 mg), or placebo daily for 2 years. Serum concentration of lutein/zeaxanthin, macular pigment optical density (MPOD), visual functions including best-spectacle corrected visual acuity (BCVA), contrast sensitivity (CS), flash recovery time (FRT), and vision-related quality of life (VFQ25) was quantified. Results. Serum lutein concentration and MPOD significantly increased in all the active treatment groups. Supplementation with 20 mg lutein was the most effective in increasing MPOD and CS at 3 cycles/degree for the first 48 weeks. However, they both significantly increased to the same peak value following supplementation with either 10 mg or 20 mg lutein during the intervention. No statistical changes of BCVA or FRT were observed during the trial. Conclusions. Long-term lutein supplementation could increase serum lutein concentration, MPOD, and visual sensitivities of early AMD patients. 10 mg lutein daily might be an advisable long-term dosage for early AMD treatment.

语种: 英语
所属项目编号: 81273063
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000351375600001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55674
Appears in Collections:北京大学第三临床医学院_眼科_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Ctr Eye, Beijing 100191, Peoples R China

Recommended Citation:
Huang, Yang-Mu,Dou, Hong-Liang,Huang, Fei-Fei,et al. Effect of Supplemental Lutein and Zeaxanthin on Serum, Macular Pigmentation, and Visual Performance in Patients with Early Age-Related Macular Degeneration[J]. BIOMED RESEARCH INTERNATIONAL,2015.
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