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学科主题: 临床医学
题名:
Comparison between self-assembling peptide nanofiber scaffold (SAPNS) and fibrin sealant in neurosurgical hemostasis
作者: Xu, Fei-fan1,2; Wang, Yue-chun2,3; Sun, Stella2; Ho, Amy S. W.2; Lee, Derek2; Kiang, Karrie M. Y.2; Zhang, Xiao-qin2; Lui, Wai-man2; Liu, Bai-yun4,5,6; Wu, Wu-tian7; Leung, Gilberto K. K.2
关键词: fibrin sealant ; hemostasis ; inflammation ; nanomaterial ; RADA16-I ; surgical brain injury ; SAPNS
刊名: CTS-CLINICAL AND TRANSLATIONAL SCIENCE
发表日期: 2015-10-01
DOI: 10.1111/cts.12299
卷: 8, 期:5, 页:490-494
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: REGENERATION ; BRAIN ; CELLS ; RECONSTRUCTION ; NANOTECHNOLOGY ; HYDROGEL ; DESIGN
英文摘要:

RADA16-I is a synthetic type I self-assembling peptide nanofiber scaffold (SAPNS) which may serve as a novel biocompatible hemostatic agent. Its application in neurosurgical hemostasis, however, has not been explored. Although RADA16-I is nontoxic and nonimmunogenic, its intrinsic acidity may potentially provoke inflammation in the surgically injured brain. We conducted an animal study to compare RADA16-I with fibrin sealant, a commonly used agent, with the hypothesis that the former would be a comparable alternative. Using a standardized surgical brain injury model, 30 Sprague-Dawley rats were randomized into three treatment groups: RADA16-I, fibrin sealant or gelatin sponge (control). Animals were sacrificed on day 3 and 42. Astrocytic and microglial infiltrations within the cerebral parenchyma adjacent to the operative site were significantly lower in the RADA16-I and fibrin sealant groups than control. RADA16-I did not cause more cellular inflammatory response despite its acidity when compared with fibrin sealant. Immunohistochemical studies showed infiltration by astrocytes and microglia into the fibrin sealant and RADA16-I grafts, suggesting their potential uses as tissue scaffolds. RADA16-I is a promising candidate for further translational and clinical studies that focus on its applications as a safe and effective hemostat, proregenerative nanofiber scaffold as well as drug and cell carrier.

语种: 英语
所属项目编号: 02132186
项目资助者: Health and Medical Research Fund, Food and Health Bureau, The Government of the HKSAR
WOS记录号: WOS:000363652100014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55675
Appears in Collections:北京大学第一临床医学院_神经外科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Neurosurg, Beijing 100871, Peoples R China
2.Univ Hong Kong, Queen Mary Hosp, Li Ka Shing Fac Med, Div Neurosurg, Hong Kong, Hong Kong, Peoples R China
3.China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China
4.Jinan Univ, Coll Med, Dept Physiol, Guangzhou, Guangdong, Peoples R China
5.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China
6.Capital Med Univ, Beijing Neurosurg Inst, Neurotrauma Lab, Beijing, Peoples R China
7.Univ Hong Kong, Li Ka Shing Fac Med, Dept Anat, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Xu, Fei-fan,Wang, Yue-chun,Sun, Stella,et al. Comparison between self-assembling peptide nanofiber scaffold (SAPNS) and fibrin sealant in neurosurgical hemostasis[J]. CTS-CLINICAL AND TRANSLATIONAL SCIENCE,2015,8(5):490-494.
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