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Comparison between self-assembling peptide nanofiber scaffold (SAPNS) and fibrin sealant in neurosurgical hemostasis
Xu, Fei-fan1,2; Wang, Yue-chun2,3; Sun, Stella2; Ho, Amy S. W.2; Lee, Derek2; Kiang, Karrie M. Y.2; Zhang, Xiao-qin2; Lui, Wai-man2; Liu, Bai-yun4,5,6; Wu, Wu-tian7; Leung, Gilberto K. K.2
关键词Fibrin Sealant Hemostasis Inflammation Nanomaterial Rada16-i Surgical Brain Injury Sapns
刊名CTS-CLINICAL AND TRANSLATIONAL SCIENCE
2015-10-01
DOI10.1111/cts.12299
8期:5页:490-494
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]REGENERATION ; BRAIN ; CELLS ; RECONSTRUCTION ; NANOTECHNOLOGY ; HYDROGEL ; DESIGN
英文摘要

RADA16-I is a synthetic type I self-assembling peptide nanofiber scaffold (SAPNS) which may serve as a novel biocompatible hemostatic agent. Its application in neurosurgical hemostasis, however, has not been explored. Although RADA16-I is nontoxic and nonimmunogenic, its intrinsic acidity may potentially provoke inflammation in the surgically injured brain. We conducted an animal study to compare RADA16-I with fibrin sealant, a commonly used agent, with the hypothesis that the former would be a comparable alternative. Using a standardized surgical brain injury model, 30 Sprague-Dawley rats were randomized into three treatment groups: RADA16-I, fibrin sealant or gelatin sponge (control). Animals were sacrificed on day 3 and 42. Astrocytic and microglial infiltrations within the cerebral parenchyma adjacent to the operative site were significantly lower in the RADA16-I and fibrin sealant groups than control. RADA16-I did not cause more cellular inflammatory response despite its acidity when compared with fibrin sealant. Immunohistochemical studies showed infiltration by astrocytes and microglia into the fibrin sealant and RADA16-I grafts, suggesting their potential uses as tissue scaffolds. RADA16-I is a promising candidate for further translational and clinical studies that focus on its applications as a safe and effective hemostat, proregenerative nanofiber scaffold as well as drug and cell carrier.

语种英语
WOS记录号WOS:000363652100014
项目编号02132186
资助机构Health and Medical Research Fund, Food and Health Bureau, The Government of the HKSAR
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55675
专题北京大学第一临床医学院_神经外科
作者单位1.Peking Univ, Hosp 1, Dept Neurosurg, Beijing 100871, Peoples R China
2.Univ Hong Kong, Queen Mary Hosp, Li Ka Shing Fac Med, Div Neurosurg, Hong Kong, Hong Kong, Peoples R China
3.China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China
4.Jinan Univ, Coll Med, Dept Physiol, Guangzhou, Guangdong, Peoples R China
5.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China
6.Capital Med Univ, Beijing Neurosurg Inst, Neurotrauma Lab, Beijing, Peoples R China
7.Univ Hong Kong, Li Ka Shing Fac Med, Dept Anat, Hong Kong, Hong Kong, Peoples R China
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GB/T 7714
Xu, Fei-fan,Wang, Yue-chun,Sun, Stella,et al. Comparison between self-assembling peptide nanofiber scaffold (SAPNS) and fibrin sealant in neurosurgical hemostasis[J]. CTS-CLINICAL AND TRANSLATIONAL SCIENCE,2015,8(5):490-494.
APA Xu, Fei-fan.,Wang, Yue-chun.,Sun, Stella.,Ho, Amy S. W..,Lee, Derek.,...&Leung, Gilberto K. K..(2015).Comparison between self-assembling peptide nanofiber scaffold (SAPNS) and fibrin sealant in neurosurgical hemostasis.CTS-CLINICAL AND TRANSLATIONAL SCIENCE,8(5),490-494.
MLA Xu, Fei-fan,et al."Comparison between self-assembling peptide nanofiber scaffold (SAPNS) and fibrin sealant in neurosurgical hemostasis".CTS-CLINICAL AND TRANSLATIONAL SCIENCE 8.5(2015):490-494.
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