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学科主题: 临床医学
题名:
Decreased N-13-labeled ammonia uptake in the ipsilateral and contralateral hemispheres following carotid endarterectomy
作者: Wang, Tao1,2; Wang, Xuemei3; He, Yulin3; Zhang, Tao3; Song, Jianqiang1; Bai, Xia3; Han, Chunlei4
关键词: ammonia ; positron emission tomography ; carotid endarterectomy
刊名: MOLECULAR MEDICINE REPORTS
发表日期: 2015-11-01
DOI: 10.3892/mmr.2015.4303
卷: 12, 期:5, 页:6598-6604
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Medicine, Research & Experimental
研究领域[WOS]: Oncology ; Research & Experimental Medicine
关键词[WOS]: POSITRON-EMISSION-TOMOGRAPHY ; STENTING TRIAL CREST ; CEREBRAL-BLOOD-FLOW ; REVASCULARIZATION ENDARTERECTOMY ; HYPERPERFUSION SYNDROME ; HEPATIC-ENCEPHALOPATHY ; HEMODYNAMIC-CHANGES
英文摘要:

Carotid artery plaques are a leading cause of ischemic stroke, and carotid endarterectomy (CEA) is one of the major treatment approaches for this disease. Changes in cerebral metabolism following CEA remain unclear. The present study aimed to evaluate the effect of cerebral ammonia metabolism following CEA using N-13-labeled ammonia positron emission tomography (PET) in humans. A total of 20 patients were enrolled in the present study, with a mean age of 59.5 years, comprising 16 males and four females. Of these patients, eight underwent right CEA and 12 underwent left CEA. The rate of carotid artery stenosis was between 50-69% in six of the patients, between 70-99% in 11 of the patients and was at 100% (thrombosis) in three of the patients, measured by computerised tomography digital subtraction angiography prior to CEA. N-13-labeled ammonia (137 MBq) PET scanning was performed prior and subsequent to CEA surgery for each patient. The first ammonia PET scan was performed 1 day prior to CEA, while the second PET scan was performed 1-4 weeks following CEA. Following injection of N-13-labeled ammonia, static PET was acquired for 10 min. The region of interest (ROT), covering the major cerebral hemisphere, was selected and ammonia uptake in the ROT was determined in the ipsilateral and contralateral hemispheres. No hyperperfusion syndrome was observed in the patients subsequent to CEA. No significant change in cerebral hemisphere ammonia uptake was observed between the ipsilateral and contralateral hemispheres prior to (ratio =0.98; P>0.01) or following (ratio =1.09; P>0.01) CEA Ammonia uptake in the ipsilateral and contralateral hemispheres was significantly reduced to 23.2 and 23.5%, respectively, following CEA. Using N-13-labeled ammonia PET to evaluate cerebral ammonia metabolism following CEA in patients with severe carotid artery stenosis, the present study demonstrated that uptake of ammonia in the ipsilateral and contralateral hemispheres was significantly reduced.

语种: 英语
所属项目编号: NYFYBZ2010005 ; 20080404MS1125 ; 2010024
项目资助者: Key project from Affiliated Hospital of Inner Mongolia Medical University ; Natural Science Foundation of Inner Mongolia ; Medical Research Plan of Inner Mongolia Public Health ; Scientific and Technological Project of Inner Mongolia Education ; Centre of Excellence in Cardiovascular and Metabolic Imaging of Academy of Finland
WOS记录号: WOS:000364888900026
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55678
Appears in Collections:北京大学第三临床医学院_神经外科_期刊论文

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作者单位: 1.Turku Univ Hosp, Turku PET Ctr, Turku 20520, Finland
2.Inner Mongolia Med Univ, Affiliated Hosp, Dept Neurosurg, Hohhot 010050, Inner Mongolia, Peoples R China
3.Peking Univ, Hosp 3, Dept Neurosurg, Beijing 100191, Peoples R China
4.Inner Mongolia Med Univ, Affiliated Hosp, Dept Nucl Med, Hohhot 010050, Inner Mongolia, Peoples R China

Recommended Citation:
Wang, Tao,Wang, Xuemei,He, Yulin,et al. Decreased N-13-labeled ammonia uptake in the ipsilateral and contralateral hemispheres following carotid endarterectomy[J]. MOLECULAR MEDICINE REPORTS,2015,12(5):6598-6604.
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