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Decreased N-13-labeled ammonia uptake in the ipsilateral and contralateral hemispheres following carotid endarterectomy
Wang, Tao1,2; Wang, Xuemei3; He, Yulin3; Zhang, Tao3; Song, Jianqiang1; Bai, Xia3; Han, Chunlei4
关键词Ammonia Positron Emission Tomography Carotid Endarterectomy
刊名MOLECULAR MEDICINE REPORTS
2015-11-01
DOI10.3892/mmr.2015.4303
12期:5页:6598-6604
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Medicine, Research & Experimental
研究领域[WOS]Oncology ; Research & Experimental Medicine
关键词[WOS]POSITRON-EMISSION-TOMOGRAPHY ; STENTING TRIAL CREST ; CEREBRAL-BLOOD-FLOW ; REVASCULARIZATION ENDARTERECTOMY ; HYPERPERFUSION SYNDROME ; HEPATIC-ENCEPHALOPATHY ; HEMODYNAMIC-CHANGES
英文摘要

Carotid artery plaques are a leading cause of ischemic stroke, and carotid endarterectomy (CEA) is one of the major treatment approaches for this disease. Changes in cerebral metabolism following CEA remain unclear. The present study aimed to evaluate the effect of cerebral ammonia metabolism following CEA using N-13-labeled ammonia positron emission tomography (PET) in humans. A total of 20 patients were enrolled in the present study, with a mean age of 59.5 years, comprising 16 males and four females. Of these patients, eight underwent right CEA and 12 underwent left CEA. The rate of carotid artery stenosis was between 50-69% in six of the patients, between 70-99% in 11 of the patients and was at 100% (thrombosis) in three of the patients, measured by computerised tomography digital subtraction angiography prior to CEA. N-13-labeled ammonia (137 MBq) PET scanning was performed prior and subsequent to CEA surgery for each patient. The first ammonia PET scan was performed 1 day prior to CEA, while the second PET scan was performed 1-4 weeks following CEA. Following injection of N-13-labeled ammonia, static PET was acquired for 10 min. The region of interest (ROT), covering the major cerebral hemisphere, was selected and ammonia uptake in the ROT was determined in the ipsilateral and contralateral hemispheres. No hyperperfusion syndrome was observed in the patients subsequent to CEA. No significant change in cerebral hemisphere ammonia uptake was observed between the ipsilateral and contralateral hemispheres prior to (ratio =0.98; P>0.01) or following (ratio =1.09; P>0.01) CEA Ammonia uptake in the ipsilateral and contralateral hemispheres was significantly reduced to 23.2 and 23.5%, respectively, following CEA. Using N-13-labeled ammonia PET to evaluate cerebral ammonia metabolism following CEA in patients with severe carotid artery stenosis, the present study demonstrated that uptake of ammonia in the ipsilateral and contralateral hemispheres was significantly reduced.

语种英语
WOS记录号WOS:000364888900026
项目编号NYFYBZ2010005 ; 20080404MS1125 ; 2010024
资助机构Key project from Affiliated Hospital of Inner Mongolia Medical University ; Natural Science Foundation of Inner Mongolia ; Medical Research Plan of Inner Mongolia Public Health ; Scientific and Technological Project of Inner Mongolia Education ; Centre of Excellence in Cardiovascular and Metabolic Imaging of Academy of Finland
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55678
专题北京大学第三临床医学院_神经外科
作者单位1.Turku Univ Hosp, Turku PET Ctr, Turku 20520, Finland
2.Inner Mongolia Med Univ, Affiliated Hosp, Dept Neurosurg, Hohhot 010050, Inner Mongolia, Peoples R China
3.Peking Univ, Hosp 3, Dept Neurosurg, Beijing 100191, Peoples R China
4.Inner Mongolia Med Univ, Affiliated Hosp, Dept Nucl Med, Hohhot 010050, Inner Mongolia, Peoples R China
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GB/T 7714
Wang, Tao,Wang, Xuemei,He, Yulin,et al. Decreased N-13-labeled ammonia uptake in the ipsilateral and contralateral hemispheres following carotid endarterectomy[J]. MOLECULAR MEDICINE REPORTS,2015,12(5):6598-6604.
APA Wang, Tao.,Wang, Xuemei.,He, Yulin.,Zhang, Tao.,Song, Jianqiang.,...&Han, Chunlei.(2015).Decreased N-13-labeled ammonia uptake in the ipsilateral and contralateral hemispheres following carotid endarterectomy.MOLECULAR MEDICINE REPORTS,12(5),6598-6604.
MLA Wang, Tao,et al."Decreased N-13-labeled ammonia uptake in the ipsilateral and contralateral hemispheres following carotid endarterectomy".MOLECULAR MEDICINE REPORTS 12.5(2015):6598-6604.
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