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学科主题: 药学
题名:
Mitochondrial apoptosis contributes to the anti-cancer effect of Smilax glabra Roxb.
作者: Gao, Yujing2; Su, Yahui2; Qu, Like2; Xu, Shuo; Meng, Lin2; Cai, Shao-Qing1; Shou, Chengchao2
关键词: Smilax glabra Roxb. ; Anti-cancer effect ; Apoptosis ; Mitochondria
刊名: TOXICOLOGY LETTERS
发表日期: 2011-11-30
DOI: 10.1016/j.toxlet.2011.08.024
卷: 207, 期:2, 页:112-120
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Toxicology
研究领域[WOS]: Toxicology
关键词[WOS]: PROGRAMMED CELL-DEATH ; WILD SARSAPARILLA ; OXIDATIVE STRESS ; CANCER ; EXTRACT ; RHIZOME ; CALCIUM
英文摘要:

Smilax glabra Roxb. (SGR), a member of the Smilacaceae family and a rhizome of the Liliaceae plant, has shown anti-inflammation and detoxification properties, and a few studies reported its anti-cancer effect. In this study, we showed that SGR inhibited growth of human breast cancer cell line MCF7, colon carcinoma cell line HT-29, and gastric cancer cell line BGC-823 in a dose-dependent manner. Furthermore, SGR could inhibit tumor growth of HT-29 in Balb/c nude mice and murine hepatoma H22 cells in ICR mice. SGR elicited apoptotic cell death, as confirmed by DNA ladder formation, changes in nuclear morphology, and the increased FITC-Annexin-V/PI staining. Permeabilization of mitochondrial membrane (MMP), production of reactive oxygen species (ROS), elevation of intracellular [Ca(2+)], relocation of cytochrome c, and the activation of caspase-3 were found to be associated with the initiation of apoptosis by SGR treatment. Using microarray analysis, we found the changes in expression profiles of genes related to apoptosis, proliferation and cell cycle control in the cells treated with SGR. Our results demonstrated the mitochondrial regulation of apoptosis by which SGR exerts the anti-cancer effect. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 2009CB521805 ; 30830120
项目资助者: National 973 Program of China ; National Natural Science Foundation of China
WOS记录号: WOS:000297184100003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55680
Appears in Collections:北京大学药学院_天然药物学系_期刊论文

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作者单位: 1.Peking Univ, Dept Nat Med, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Canc Hosp & Inst, Dept Biochem & Mol Biol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China

Recommended Citation:
Gao, Yujing,Su, Yahui,Qu, Like,et al. Mitochondrial apoptosis contributes to the anti-cancer effect of Smilax glabra Roxb.[J]. TOXICOLOGY LETTERS,2011,207(2):112-120.
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