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Mitochondrial apoptosis contributes to the anti-cancer effect of Smilax glabra Roxb.
Gao, Yujing2; Su, Yahui2; Qu, Like2; Xu, Shuo; Meng, Lin2; Cai, Shao-Qing1; Shou, Chengchao2
关键词Smilax Glabra Roxb. Anti-cancer Effect Apoptosis Mitochondria
刊名TOXICOLOGY LETTERS
2011-11-30
DOI10.1016/j.toxlet.2011.08.024
207期:2页:112-120
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Toxicology
研究领域[WOS]Toxicology
关键词[WOS]PROGRAMMED CELL-DEATH ; WILD SARSAPARILLA ; OXIDATIVE STRESS ; CANCER ; EXTRACT ; RHIZOME ; CALCIUM
英文摘要

Smilax glabra Roxb. (SGR), a member of the Smilacaceae family and a rhizome of the Liliaceae plant, has shown anti-inflammation and detoxification properties, and a few studies reported its anti-cancer effect. In this study, we showed that SGR inhibited growth of human breast cancer cell line MCF7, colon carcinoma cell line HT-29, and gastric cancer cell line BGC-823 in a dose-dependent manner. Furthermore, SGR could inhibit tumor growth of HT-29 in Balb/c nude mice and murine hepatoma H22 cells in ICR mice. SGR elicited apoptotic cell death, as confirmed by DNA ladder formation, changes in nuclear morphology, and the increased FITC-Annexin-V/PI staining. Permeabilization of mitochondrial membrane (MMP), production of reactive oxygen species (ROS), elevation of intracellular [Ca(2+)], relocation of cytochrome c, and the activation of caspase-3 were found to be associated with the initiation of apoptosis by SGR treatment. Using microarray analysis, we found the changes in expression profiles of genes related to apoptosis, proliferation and cell cycle control in the cells treated with SGR. Our results demonstrated the mitochondrial regulation of apoptosis by which SGR exerts the anti-cancer effect. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000297184100003
项目编号2009CB521805 ; 30830120
资助机构National 973 Program of China ; National Natural Science Foundation of China
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55680
专题北京大学临床肿瘤学院_生化与分子生物学研究室
北京大学药学院_天然药物学系
作者单位1.Peking Univ, Dept Nat Med, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Canc Hosp & Inst, Dept Biochem & Mol Biol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
推荐引用方式
GB/T 7714
Gao, Yujing,Su, Yahui,Qu, Like,et al. Mitochondrial apoptosis contributes to the anti-cancer effect of Smilax glabra Roxb.[J]. TOXICOLOGY LETTERS,2011,207(2):112-120.
APA Gao, Yujing.,Su, Yahui.,Qu, Like.,Xu, Shuo.,Meng, Lin.,...&Shou, Chengchao.(2011).Mitochondrial apoptosis contributes to the anti-cancer effect of Smilax glabra Roxb..TOXICOLOGY LETTERS,207(2),112-120.
MLA Gao, Yujing,et al."Mitochondrial apoptosis contributes to the anti-cancer effect of Smilax glabra Roxb.".TOXICOLOGY LETTERS 207.2(2011):112-120.
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