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学科主题: 基础医学
题名:
Effect of polysaccharides from Ganoderma lucidum on streptozotocin-induced diabetic nephropathy in mice
作者: He, C. -Y.; Li, W. -D.; Guo, S. -X.; Lin, S. -Q.; Lin, Z. -B.
关键词: Ganoderma lucidum ; polysaccharides ; diabetic nephropathy ; mouse
刊名: JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
发表日期: 2006-12-01
DOI: 10.1080/10286020500289071
卷: 8, 期:8, 页:705-711
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: TGF-BETA ; GLOMERULOPATHY ; EXPRESSION ; KIDNEY
英文摘要:

The effects of Ganoderma lucidum polysaccharides (GL-PS) on renal complication in streptozotocin-induced diabetic mice have been investigated in the present study. C57BL/6J mice were made diabetic by injection of streptozotocin and GL-PS (125 and 250 mg kg(-1)) was administered for 8 weeks. Body weight was monitored every week. Serum glucose, creatinine (Cr), blood urea nitrogen (BUN), triglyceride (TG) and urinary albumin excretion (UAE) were measured after 8 weeks of treatment. Glomerular size and mesangial matrix index were assayed by morphometric analysis. Renal expression of transforming growth factor-beta(1) (TGF-beta(1)) were determined by immunochemistry. Renal malondialdehyde (MDA) level and superoxide dismutase (SOD) activities were also evaluated. GL-PS was able to reduce the serum Cr and BUN levels and UAE compared with diabetic model mice in a dose-dependent manner. Increasing serum glucose and triglyceride levels in diabetic mice could also be lowered by GL-PS. Moreover, GL-PS had the capacity to improve the renal morphometric changes and oxidative stress state of diabetic mice. In summary, GL-PS can improve the metabolic abnormalities of diabetic mice and prevent or delay the progression of diabetic renal complications.

语种: 英语
WOS记录号: WOS:000242552500006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55688
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Pharmacol, Beijing 100083, Peoples R China
2.Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100094, Peoples R China
3.Peking Union Med Coll, Beijing 100094, Peoples R China
4.Fuzhou Green Valley Inst Biopharmaceut Technol, Fuzhou 350002, Peoples R China

Recommended Citation:
He, C. -Y.,Li, W. -D.,Guo, S. -X.,et al. Effect of polysaccharides from Ganoderma lucidum on streptozotocin-induced diabetic nephropathy in mice[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2006,8(8):705-711.
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